Zhang Lab Home

Links to these Articles are available on the IN THE NEWS page. September 2008 The Zhang lab turns human skin cells into insulin-producing cells. -Science Daily July 2008 Yi Zhang receives the first Battle Distinguished Cancer Reserach Award. -UNC News April 2008 Work from the Zhang Lab is ranked #7 in terms of impact factor. -Sciencewatch.com March 2008 Demystifying Histone Demethylases -The Scientist October 2007 Sperm gene sparks fertility hope. -BBC News Gene defects could be new cause of male infertility. -UNC news August 2006 Study identifies molecular process underlying leukemia. -UNC News June 2006 Novel enzyme offers new look at male hormone regulation; UNC scientists' findings have implications for prostate cancer -UNC News May 2006 -Yamane et.al. Cell. rated a "Must Read" 6.0 by Faculty of 1000. -Huang et.al. Science. rated a "Must Read" 6.0 by Faculty of 1000. -Wang et.al. Mol.Cell. rated a "Must Read" 6.0 by Faculty of 1000. January 2006 Tsukada et.al. Nature. rated an "Exceptional" 9.7 by Faculty of 1000. December 2005 New Discoveries Speak Volumes about how Genes are Silenced. -HHMI News September 2005 Yi Zhang named Howard Hughes Medical Institute investigator. -unchealthcare.org April 2005 Enzyme activity promotes rare form of leukemia, offers potential target for new drugs. -medicalnewstoday.com April 2005 UNC scientists idenitify potential new cancer drug target. November 2004 How Ubiquitin Silences Genes. -genomebiology.com October 2004 Wang et.al. (2004) Nature. rated a "Must Read" 6.7 by Faculty of 1000 September 2004 New molecular link key to cellular proteins involved in cancer progression, other diseases. -medicalnewstoday.com September 2004 Yi Zhang awarded the UNC Hettleman Prize. -unchealthcare.org November 2003 Wang et.al. (2003) Mol Cell. rated a "Must Read" 6.0 by Faculty of 1000. September 2003 UNC researchers identify protein crucial to gene silencing. -scienceblog.com April 2003 Zhang receives prestigious award for cancer research. -unchealthcare.org December 2002 Cao et.al. (2002) Science. rated a "Must Read" 6.0 by Faculty of 1000. October 2002 Study helps explain gene silencing in the developing embryo. -scienceblog.com September 2002 Histone Tails. -Endeavors Magazine December 2001 Protein Discovery tied to DNA master Switch. -sciencedaily.com

Fig.2. iPS cells generated from human foreskin cells have the potential to differentiate into the three germ layers in vivo.
A. Low magnification of HE staining of a section from a representative human iPS cell-derived teratoma. Cells of different lineages were observed within the tumor section.
B and C. Cells of ectoderm lineage, such as the neuroprogenitors rosettes and epidermal cells suggested by HE staining (B, arrow), were confirmed by nestin (red) and cytokeratin 19 (green) staining (C).
D and E. Cells of mesoderm lineage, such as the fat tissue and smooth muscle cells seen in HE staining (D, arrow), were confirmed by alpha smooth muscle actin (red) and myosin heavy chain (green) staining (E).
F. HE staining reveals gut-like and airway epithelial structure, representative of endoderm lineage.

Fig.4B. Immunostaining of pancreatic lineage marker proteins in hES (a, d, g, j, m and n) and iPS (b, c, e, f, h, i, k, l, o, p, q, r) derived cells. a-f, stained after stage 1; g-i, stained after stage2; j-l, C-peptide and glucagon staining after stage 4. m-r, high magnification of C-peptide and glucagon staining. Bar = 500 μm (a-l); 10 μm (m-r).

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last updated Sept 11, 2008

from Tateishi et al. JBC 2008

Converting human skin cells into insulin producing cells through reprogramming.