- Dr. Arlene S. Bridges
- Valproic acid reduces the tolerability of temsirolimus in children and adolescents with solid tumors.
- P-Glycoprotein Increases Portal Bioavailability of Loperamide in Mouse by Reducing First-Pass Intestinal Metabolism.
- Compartmental and enzyme kinetic modeling to elucidate the biotransformation pathway of a centrally acting antitrypanosomal prodrug.
- Plasma, tumor and tissue pharmacokinetics of Docetaxel delivered via nanoparticles of different sizes and shapes in mice bearing SKOV-3 human ovarian carcinoma xenograft.
- Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine.
- A mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent models.
- Impact of organic solvents on cytochrome P450 probe reactions: filling the gap with (S)-Warfarin and midazolam hydroxylation.
- Pilot study of rosiglitazone as an in vivo probe of paclitaxel exposure.
- Cyclophosphamide and 4-hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis.
- Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons.
- Biography
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Dr. Arlene Bridges has been the Director of the ADME Mass Spectrometer Center at UNC since it began operation in 2003. She has over 15 years of experience in developing, validating, and running bioanalytical methods using HPLC-MS/MS. This includes formal training by Agilent, Thermo-Fisher Scientific, and Applied Biosystems (now AB Sciex) in the operation and maintenance of triple quadrupole mass spectrometers, ion trap mass spectrometers, and HPLCs. Her background in toxicology and pharmacology from the University of Wisconsin-Madison and her doctoral training from the University of North Carolina at Chapel Hill give her a unique perspective of how mass spectrometry can be used to answer questions regarding drug development and testing. Given her expertise and commitment to collaboration, Dr. Bridges is uniquely positioned to make an impact on the scientific research of faculty, fellows, graduate students and trainees.
