Advanced Directives/Palliative Care

 Diem SJ, Lantos JD, Tulsky JA. Cardiopulmonary resuscitation on television: miracles and misinformation. NEJM. 1996; 334: 1578-1582.

 McCue JD. The Naturalness of Dying. JAMA. 1995; 273: 1039-1043.

 

Morrison RS, Meier DM. Palliative Care. NEJM. 2004; 350: 2582-2590.

Murphy DJ, Burrows D, Santilli S, Kemp AW, TEnner S, Kreling B, Teno J. The influence of the probability of survival on patient's preferences regarding cardiopulmonary resuscitation. NEJM. 1994; 330: 545-549.

Quill TE, Arnold RM, Platt F. "I wish things were different". Expressing wishes in response to loss, futility, and unrealistic hopes. Ann Int Med. 2001; 135: 551-555.

Rabow MW, Hauser JM, Adams J. Supporting family caregivers at the end of life. "They don't know what they don't know." JAMA. 2004; 483-491.

Cardiovascular

 

Anticoagulation for Chronic Atrial Fibrillation, Stern S, etal. JAMA 2000. 283:2901-2903.

Etiology of large pericardial effusions. Corey GR, et al. American J. of Medicine 1993. 95:209-213.

 

Clinical clues to the causes of large pericardial effusions. Sagrista-Sauleda J, et al. American J. of Medicine 2000. 109:95-101.

Left ventricular diastolic dysfunction as a cause of congestive heart failure. Bonow RO, et al. Annals of Int Med 1992. 117:502-510

 

The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery. Poldermans D, et al. NEJM 1999. 341:1789-94.

Effect of coronary bypass graft surgery on survival: overview of 10-year results from randomised trials by the coronary artery bypass graft surgery trialists collaboration. Yusuf S, et al. Lancet 1994. 344:563-70

Implantable cardioverter defibrillators in primary and secondary prevention: A systematic review of randomized, controlled trials. Ezekowitz JA, et al. Annals of Internal Medicine 203. 138:445-52.

 

Hypertrophic and restrictive cardiomyopathies in the elderly. Zieman SJ et al. Cardiology Clinics 1999. 17:159-172.

 

Outcome of elderly patients with chronic symptomatic coronary artery disease with an invasive vs. optimized medical treatment strategy. TIME trial. JAMA 2003. 289:117-1123. ( good to read this with caution).

Effects of intensive blood-pressure lowering and low dose aspirin in patients with HTN: principal results of the hypertension optimal treatment (HOT) trial. Hansson L, et al. Lancet 1998. 351_1755-62.

 

Cornoary angioplasty vs. medical therapy for angina: the second randomized intervention treatment of angina (RITA-2). RITA -2 trialists. Lancet 1997. 350:461-68.

Clopidogrel vs aspirin and omeprazole to prevent recurrent ulcer bleeding. Chan F. K.L et al. NEJM 2005; 352:238-244, Jan 20, 2005.

Effect of diuretic based antihypertensive treatment on cardiovascular disease risk in older diabetic patients with isolated systolic hypertension. Curb JD, et al. JAMA 1996. 276:1886-92

Aurigemma GP, Gaasch WH. Diastolic Heart Failure. NEJM. 2004; 351: 1097-1105.

Chaudry SI, Krumholz HM, Foody JM. Systolic Hypertension in Older Persons. JAMA. 2004; 292: 1074-1080.

Aurigemma GP, Gaasch WH. Diastolic Heart Failure. NEJM 351: 1097-1105 (September 9, 2004).

 

Cellulitis

 

Outpatient management of uncomplicated lower extremity infections in diabetic patients. Lipsky BA, et al. Arch Int Medicine 1990. 150:790-97.

Colon

Stollman N, Raskin JB. Diverticular disease of the colon. The Lancet. 363: 9409; 631-639. Feb 2004.

 Constipation - Impaction - Pseudoobstruction

Go-lytely: a new approach to fecal impaction in old age. Puxty JAH, et al. Age and Aging 1986. 15:182-184.

CVA

A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke. Mohr JP, et al. NEJM 2001. 345:1444-51.

 

Vasculitis of the central nervous system, Calabrese LH. Rheumatic Dis Clinics of NA 1995. 21:1059-1076.

 

Endarterectomy for asymptomatic carotid artery stenosis. Exec Comm for ACAS. JAMA 1995. 273:1421-1428.

 Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. NCAS trialsists. NEJM 1991.325:445-53.

 

Choosing antithrombotic therapy for elderly patients with atrial fibrillation who are at risk for falls. Man-Son-Hing M et al. Arch Int Med 1999. 159:677-85.

European Stroke Prevention Study: 2 asprin plus dipyridamole for secondary prevention of stroke. J. Neurol Sci. 1996. 143:1-13.

 

Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial Diener , HC, Lancet 364:331-7.

Dementia

 

Aphasia, Geshwind N. NEJM 1971:284:654-6

 

Aphasia. Damasio AR. NEJM 1992. 326:531-9

Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales . Neuropathology study group. Lancet 2001. 357:169-75.

Mixed dementia, emerging concepts and therapeutic implications. Langa KM, et al. JAMA 2003. 292:2901-2908.

 

The Dementias. Ritchie K and Lovestone S. Lancet 2002. 360:1759-66.

Abnormality of Gait as a predictor of non-Alzheimer's dementia. Verghese J, et al. NEJM 2002. 347:1761-8.

Tales from the temporal lobes. Zeman A. NEJM 2005. 352:119-121.

The permanent vegetative state. Wade DT, et al. BMJ 1999. 319:841-4.

Pharmacological treatment of neuropsychiatric symptoms of dementia. Sink KM, et al. JAMA 2005. 293:596-608.

Paraneoplastic neurologic syndromes. Bataller L et al. Neurol Clinics of NA 2003. 21:221-47.

Effects of rofecoxib or naproxen vs. placebo on Alzheimer disease progression. Aisen PA et al. JAMA 2003. 289:2819-26.

Medical aspects of the persistent vegetative state. Mult Society Task Force. NEJM 1994. 330:1499-508.

 

Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psych Res. 1975; 12: 189-198.

 

Hurley AC, Volicer L. Alzheimer Disease. "It's Okay, Mama, If you want to go, it's okay." JAMA. 2002; 288: 2324-2331.

Delirium

Inouye SK, Bogardus ST, Charpentier PA, Leo-Summers L, Acampora D, Holford TR, Cooney LM. A multicomponent intervention to prevent delirium in hospitalized older patients. NEJM. 1999; 340: 669-676.

Pharmacological treatment of neuropsychiatric symptoms of dementia" Sink KM, Holden KF, Yaffe K; JAMA Feb 2 2005; 293(5); 596-608.

An approach to drug induced delirium in the elderly. K  Alagiakrishnan and CA Wiens. Postgraduate Journal 2004; 80: 388-393.

Increased mortality among elderly patients with dementia using atypical antipsychotics. S. Singh and E. Wooltorton CMAJ; Aug 2005; 173 (3).

Delirium in older persons. S. Inouye. NEJM; March 16, 2006; 354(11); 1157-65.

Diabetes

Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes. Nissen, Steven E., MD and Kathy Wolski, MPH. NEJM; 2007; 356.

Discharge Planning of Frail Elders

Cooney LM, Kennedy GJ, Hawkins KA, Hurme SB. Who Can Stay at Home? Assessing the Capacity to Choose to Live in the community. Arch Int Med 2004; 164: 357-360.

Gill TM, Baker DI, Gottschalk M, Peduzzi PN, Allore H, Byers A. A program to prevent functional decline in physically frail, elderly persons who live at home. NEJM. 2002; 347: 1068-1074.

Endocrinologic

 

Intensive insulin therapy in critically ill patients. Van den Berghe G, et al. NEJM 2001. 345:1359-67.

Insulin therapy for critically ill hospitalizad patients. Pittas AG, et al. Arch Int Med 2004. 164:2005-2011.

 

Effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes meullitus. DCCT trialists. NEJM 1993. 329:977-86.

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UKPDS Study Group. Lancet 1998. 352:837-53.

Low dose HCTZ and preservation of bone mineral density in older adults. LaCroix AZ et al. Ann Intern Med 2000. 133:516-26.

Falls and Fracture Reduction

Tinetti ME. Preventing falls in elderly persons. NEJM. 2003; 348: 42-49.

Gait Disorders

 

Human walking and higher level gait disorders, particularly in the elderly. Nutt JG, et al. Neurology 1993. 43268-279.

 

 Gastroenterology

Clostridium difficile colitis. Kelly CP et al. NEJM. 1994. 330:257-262.

Acute mesenteric ischemia. Kaleya RN, et al. Critical Care Clinics 1995. 11:479-511.

 Heme/Onc

 

Treatment of cancer-associated hypercalcemia. Gucalp R, et al. Arch Int Med 1994. 154:1935-44.

Myelodysplasia. Heaney ML et al. NEJM 1999. 340:1649-60.

Likelihood ratios for modern screening mammography. Kerlikowske K et al. JAMA 1996. 276:39-43.

The common anemias. Beutler E. JAMA 1988. 259:2433-7.

 

Labyrinthitis

 

Methylprednisolone, valacyclovir or the combination for vestibular neuritis. Strupp M, et al. NEJM 2004. 351:354-61.

Management of the Hip Fracture Patient

Morrison RS, Magaziner J, Gilbert M, Koval, KJ, McLaughlin, MA, Orosz, G, Strauss E, Siu AL. Relationship between Pain and Opiod Analgesics on the Development of Delirium Following Hip Fracture. Journal of Gerontology 58A(1): 76–81.

Best Practices for Elderly Hip Fracture Patients: A Systematic Overview of the Evidence. Beaupre L et al. JGIM.

Haloperidol Prophylaxis for Elderly Hip-Surgery Patients at Risk for Delirium: A Randomized Placebo-Controlled Study. Kalisvaart KJ et al. JAGS 53:1658–1666, 2005.

Care of the Hip Fracture Patient. Bynum, D. PowerPoint training module.

MGUS/Amyloid

Molecular mechanisms of amyloidosis. Merlini G, et al. NEJM. 2003. 349:583-96.

Oncology

Calcium Plus Vitamin D Supplementation and the Risk of Colorectal Cancer. New England Journal of Medicine. 354:7. February 16, 2007, pp. 684 - 697.

Accuracy of Ultrasonography, Spiral CT, Magnetic Resonance, and Alpha-Fetoprotein in Diagnosing Hepatocellular Carcinoma: A Systematic Review

Peripheral Neuropathy

 

Understanding nerve conduction and electomyographic studies. Iyer VG. Hand Clinics 1993. 9:273-287.

 

Peripheral neuropathy. England JD et al. Lancet 2004. 363:2151-61.

Overview of Motor neuron Disease. Bradley WG. Clinical Neuroscience 1996. 3:323-326.

 

Peripheral Vascular Disease

 Immediate repair compared with surveillance of small abdominal aortic aneurysms. Lederle FA, et al. NEJM 2002. 346:1437-44.

Atheroembolic disease. Robson MG, et al. Br J Hosp Med. 1996. 55:648-52

The Multicentre Aneurysm Screening Study (MASS) into the effect of abdominal aortic aneurysm screening on mortality in men: a randomised controlled trial. Mass Trialists. Lancet 2002. 360:1531-8.

Mortality results for randomised controlled trial of early elective surgery or ultrasonographic surveillance for small abdominal aortic aneurysm. Lancet 1998. 352:1649-54.

Pneumonia

Overview of community-acquired pneumonia. Campbell GD. Med Clinics of NA 1994. 78:1035-47.

 

Effectivness of pneumococcal polysaccharide vaccine in older adults. Jackson LA, et al. NEJM 2003. 348:1747-55.

 

 

Polypharmacy, Appropriate Medication Use in the Elderly, Reduction of Medication Errors

Fick DM, Cooper JW, Wade WE, Waller JL, Maclean R, Beers MH. Updating the Beers Criteria for potentially inappropriate medication use in older adults. Arch Int Med 2003; 163: 2716-2724.

 

Mason C, Givler A. Name Brand medically necessary: Do Not Substitute. JAMA. 2004; 291: 1541-1542.

Psychiatry

Personality disorders. Oldham JM. JAMA 1994. 272:1770-76.

 

Yesavage JA, Brink TL, Lum O, Huang V, Adey M, Leirer VO. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 1982-1983; 17: 37-49.