Research Interests
The Boettiger lab studies the problem of addiction from a cognitive perspective. We are interested in determining how certain cognitive processes differ in people with a personal or family history of addiction. We are also interested in determining the cognitive effects of addiction treatments and the brain mechanisms of such effects. Our ultimate goal is to make discoveries that improve treatment and prevention of this common and debilitating neurobehavioral disorder.
Our techniques include combining discrete cognitive tasks in human subjects with neuroimaging, pharmacology, physiological monitoring, and genetics.
Center Line Articles
Boettiger Joins CAS Faculty (Vol 19, No 3)
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Recent Publications
Click here for a full list of publications from PubMed
Age modulates the effect of COMT genotype on delay discounting behavior. Smith CT, Boettiger CA. Psychopharmacology (Berl). 2012 Aug;222(4):609-17. Epub 2012 Feb 18.
Interaction between family history of alcoholism and Locus of Control in the opioid regulation of impulsive responding under the influence of alcohol. Altamirano LJ, Fields HL, D'Esposito M, Boettiger CA. Alcohol Clin Exp Res. 2011 Nov;35(11):1905-14. doi: 10.1111/j.1530-0277.2011.01535.x. Epub 2011 May 13.
Targeting cognitive-affective risk mechanisms in stress-precipitated alcohol dependence: an integrated, biopsychosocial model of automaticity, allostasis, and addiction. Garland EL, Boettiger CA, Howard MO. Med Hypotheses. 2011 May;76(5):745-54. Epub 2011 Feb 26.
Attentional bias toward cigarette cues in active smokers. Chanon VW, Sours CR, Boettiger CA. Psychopharmacology (Berl). 2010 Oct;212(3):309-20.
Mindfulness training modifies cognitive, affective, and physiological mechanisms implicated in alcohol dependence: results of a randomized controlled pilot trial. Garland EL, Gaylord SA, Boettiger CA, Howard MO. J Psychoactive Drugs. 2010 Jun;42(2):177-92.
Impulsivity, frontal lobes and risk for addiction. Crews FT, Boettiger CA. Pharmacol Biochem Behav. 2009 Sep;93(3):237-47.
Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network. Boettiger CA, Kelley EA, Mitchell JM, D'Esposito M, Fields HL. Pharmacol Biochem Behav. 2009 Sep;93(3):291-9.
Immediate reward bias in humans: fronto-parietal networks and a role for the catechol-O-methyltransferase 158(Val/Val) genotype. Boettiger CA, Mitchell JM, Tavares VC, Robertson M, Joslyn G, D'Esposito M, Fields HL. J Neurosci. 2007 Dec 26;27(52):14383-91.
Endogenous opioid blockade and impulsive responding in alcoholics and healthy controls. Mitchell JM, Tavares VC, Fields HL, D'Esposito M, Boettiger CA. Neuropsychopharmacology. 2007 Feb;32(2):439-49. Epub 2006 Oct 18.
Impulsive responding in alcoholics. Mitchell JM, Fields HL, D'Esposito M, Boettiger CA. Alcohol Clin Exp Res. 2005 Dec;29(12):2158-69.
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Bowles Center for Alcohol Studies at the University of North Carolina at Chapel Hill