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Faculty & Research

George Breese, Ph.D.

Division Head
Preclinical Neuropsychopharmacology &
Bowles Center for Alcohol Studies

Professor
Departments of Psychiatry and Pharmacology

Research Scientist
Neurosciences Center

Office | 3007 Thurston-Bowles Bldg, CB 7178

Email | george_breese@med.unc.edu

Lab Website | Preclinical Neuropsychopharmacology

Research Interests

Center Line Articles

Breese Laboratory Elucidates Mechanisms of Stress in Alcohol Relapse (Vol. 20, No. 2, 2009)
Breese Laboratory Advances Kindling Model as Framework for Understanding the Behavioral Pathology of Alcoholism (Vol. 17, No.2, 2006)

When Abstinence Can Be Harmful: The Dangers of Repeated Withdrawals from Alcohol (Vol 13, No. 1, 2002)

Recent Publications

Click here for a full list of publications from PubMed

Click here for selected publications from Author

Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse. Breese GR, Sinha R, Heilig M. Pharmacol Ther. 2011 Feb;129(2):149-71.

Ethanol-enhanced GABA release: a focus on G protein-coupled receptors. Kelm MK, Criswell HE, Breese GR. Brain Res Rev. 2011 Jan 1;65(2):113-23.

Interactions of stress and CRF in ethanol-withdrawal induced anxiety in adolescent and adult rats. Wills TA, Knapp DJ, Overstreet DH, Breese GR. Alcohol Clin Exp Res. 2010 Sep 1;34(9):1603-12.

The PLC/IP 3 R/PKC pathway is required for ethanol-enhanced GABA release. Kelm MK, Weinberg RJ, Criswell HE, Breese GR. Neuropharmacology. 2010 Jun;58(7):1179-86.

Corticotropin-releasing factor (CRF) sensitization of ethanol withdrawal-induced anxiety-like behavior is brain site specific and mediated by CRF-1 receptors: relation to stress-induced sensitization. Huang MM, Overstreet DH, Knapp DJ, Angel R, Wills TA, Navarro M, Rivier J, Vale W, Breese GR. J Pharmacol Exp Ther. 2010 Jan;332(1):298-307.

The alcohol deprivation effect in C57BL/6J mice is observed using operant self-administration procedures and is modulated by CRF-1 receptor signaling. Sparta DR, Ferraro FM 3rd, Fee JR, Knapp DJ, Breese GR, Thiele TE. Alcohol Clin Exp Res. 2009 Jan;33(1):31-42.

A selective ALDH-2 inhibitor reduces anxiety in rats. Overstreet DH, Knapp DJ, Breese GR, Diamond I. Pharmacol Biochem Behav. 2009 Dec;94(2):255-61.

Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbens. Besheer J, Grondin JJ, Salling MC, Spanos M, Stevenson RA, Hodge CW. J Neurosci. 2009 Jul 29;29(30):9582-91.

Sensitization, duration, and pharmacological blockade of anxiety-like behavior following repeated ethanol withdrawal in adolescent and adult rats. Wills TA, Knapp DJ, Overstreet DH, Breese GR. Alcohol Clin Exp Res. 2009 Mar;33(3):455-63.