Dr. Breese's Selected Publications
Schanberg, S.M., Schildkraut, J.J., Breese, G.R. and Kopin, I.J. Metabolism of normetanephrine-3H in rat brain -- Identification of conjugated 3-methoxy-4-hydroxy-phenylglycol as the major metabolite. Biochem. Pharmacol. 17:247-254, 1968.
Breese, G.R. and Traylor, T.D. Effects of 6- hydroxydopamine on brain norepinephrine and dopamine: Evidence for selective degeneration of catecholamine neurons. J. Pharmacol. Exp. Ther. 174: 413-420, 1970.
Breese, G.R., Cooper, B.R. and Smith, R.D. Biochemical and behavioral alterations following 6-hydroxydopamine administration into brain. In: Usdin, E. and Snyder, S. (Eds.), Frontiers in Catecholamine Research, Pergamon Press, 1973, pp. 701-706. (Reprint: Biochem. Pharmacol. 23:574-579, 1974 Suppl. Part 2).
Breese, G.R., Cott, J.M., Cooper, B.R., Prange, A.J., Jr. and Lipton, M.A. Antagonism of ethanol narcosis by thyrotropin releasing hormone. Life Sci. 14:l053-l063, l974.
Breese, G.R., Cott, J.M., Cooper, B.R., Prange, A.J., Jr., Wilson, I.C., Lipton, M.A., and Plotnikoff, N.P. Effects of thyrotropin releasing hormone (TRH) on the actions of pentobarbital and other centrally acting drugs. J. Pharmacol. Exp. Ther. 193:11-22, 1975.
Hollister, A.S., Breese, G.R., Kuhn, C.M., Cooper, B.R. and Schanberg, S.M. An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine. J. Pharmacol. Exp.Ther. 198:12-22, l976.
Frye, G.D., McCown, T.J. and Breese, G.R. Characterization of susceptibility of audiogenic seizures in ethanol-dependent rats after microinjection of alpha-amino acid (GABA) agonists into the inferior colliculus, substantia nigra, or medial septum. J. Pharmacol. Exp. Ther. 227:663-670, 1983.
Frye, G.D., McCown, T.J., Breese, G.R. and Peterson, S.L. GABAergic modulation of inferior colliculus excitability: Relationship to ethanol withdrawal audiogenic seizure susceptibility. J. Pharmacol. Exp. Ther. 237:478-485, 1986.
Criswell, H.E., Breese, G.R., Mueller, R.A. Priming of D1-dopamine receptor responses: Long lasting supersensitivity to D1-dopamine agonist following repeated administration to neonatal 6-hydroxydopamine lesioned rats. J. Neurosci., 9:125-133, 1989.
McCown, T.J., and Breese, G.R. Multiple withdrawals from chronic ethanol "kindles" inferior collicular seizure activity: evidence for kindling of seizures associated with alcoholism. Alcoholism: Clin. & Exp. Res. 14:394-399, 1990.
Givens, B.S., Breese, G.R. Electrophysiological evidence that ethanol alters function of medial septal area without affecting lateral septal function. J. Pharmacol. Exp. Ther. 253:95-103,1990.
Simson, P.E., Criswell, H.E., Johnson, K.B., and Breese, G.R. Ethanol inhibits NMDA-evoked electrophysiological activity in vivo. J. Pharmacol. Exp. Ther. 257:225-231, 1991.
Moy, S.S., Knapp, D.J., Criswell, H.E., and Breese, G.R. Flumazenil blockade of anxiety following ethanol withdrawal in rats. Psychopharmacology. 131:354-360, 1997.
Criswell, H.E., Ming, Z., Griffin, BL, Mueller, R.A. and Breese, G.R. Comparison of the effect of ethanol on NMDA- and GABA-gated currents from acutely dissociated neurons: Absence of regional differences in sensitivity to ethanol. J. Pharmacol. Exp. Ther. 304:192-199, 2003
Overstreet, D.H., Knapp, D.J., and Breese, G.R. Accentuated decrease in social interaction in rats subjected to repeated multiple alcohol withdrawals. Alcoholism: Clin. Exp. Res. 26:1259-1268, 2002
Breese, G.R., Overstreet, D.H., Knapp, D.J., Stress sensitization of the ethanol withdrawal-induced reduction in social interaction: inhibition by CRF-1 and benzodiazepine receptor antagonists and a 5-HT1A agonist. Neuropsychopharmacology 29:470-482,2004
Breese, G.R., Overstreet, D.H., Knapp, D.J. Prior multiple ethanol withdrawals enhance stress-induced anxiety-like behavior during extended abstinence: Inhibition by CRF-1 and benzodiazepine receptor antagonists and by a 5-HT1A-receptor agonist. Neuropsychopharmacology, 30:1662-1669. 2005.
Breese, G.R., Overstreet, D.H., Knapp, D.J. Conceptual framework for the etiology of alcoholism —a “kindling”/stress hypothesis. Psychopharmacology 178:367-380, 2005.
Breese, G.R., Criswell, H.E., Carta, M., Dodson, P., Hanchar, H. J., Khisti, R.T. , Mameli, M., Ming, Z., Morrow A.L., Olsen, R.W., Otis,T.S., Parsons, L.H., Penland, S.N., Roberto, M., Siggins, G.R., Valenzuela, C.F., Wllner, M. Basis of the GABAmimetic profile of ethanol. Alcoholism: Clin. Exp. Res, 30:731-744, 2006.
Knapp, D.J. Overstreet, D.H, Breese, G.R. Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and ethanol withdrawal. Alcoholism: Clin. Exp. Res In Press, 2007.
Qin, L., Breese G.R., Hong, J., Knapp, D., Crews, F.T. Systemic TNFa causes chronic neuroinflammatiion and progressive neurodegeneration. Glia In Press, 2007.
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Bowles Center for Alcohol Studies at the University of North Carolina at Chapel Hill