Faculty & Research

Hugh Criswell, Ph.D.

Adjunct Professor (Retired)
Departments of Psychiatry and Anesthesiology, UNC Neuroscience Center and the Center for Alcohol Studies

Office: 1027 Thurston Bowles Building, CB# 7178

Phone: 919-966-0505

Email | hec@med.unc.edu

Lab Website | Preclinical Neuropsychopharmacology

Center Line Articles

Criswell and Colleagues Illuminate the Mystery of Alcohol Actions (Vol 18, No 4)

Recent Publications

Click here for a list of publications from PubMed

Cytokine involvement in stress may depend on corticotrophin releasing factor to sensitize ethanol withdrawal anxiety. Knapp DJ, Whitman BA, Wills TA, Angel RA, Overstreet DH, Criswell HE, Ming Z, Breese GR. Brain Behav Immun. 2011 Jun;25 Suppl 1:S146-54. Epub 2011 Mar 4

PKCγ is required for ethanol-induced increases in GABA(A) receptor α4 subunit expression in cultured cerebral cortical neurons. Werner DF, Kumar S, Criswell HE, Suryanarayanan A, Fetzer JA, Comerford CE, Morrow AL. J Neurochem. 2011 Feb;116(4):554-63.

Ethanol-enhanced GABA release: a focus on G protein-coupled receptors. Kelm MK, Criswell HE, Breese GR. Brain Res Rev. 2011 Jan 1;65(2):113-23.

The PLC/IP 3 R/PKC pathway is required for ethanol-enhanced GABA release.  Kelm MK, Weinberg RJ, Criswell HE, Breese GR.  Neuropharmacology. 2010 Jun;58(7):1179-86.

Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB). Gray SJ, Blake BL, Criswell HE, Nicolson SC, Samulski RJ, McCown TJ, Li W. Mol Ther. 2010 Mar;18(3):570-8. Epub 2009 Dec 29. Erratum in: Mol Ther. 2010 May;18(5):1054. Li, Wuping [added].

The role of protein kinase A in the ethanol-induced increase in spontaneous GABA release onto cerebellar Purkinje neurons. Kelm MK, Criswell HE, Breese GR. J Neurophysiol. 2008 Dec;100(6):3417-28.

Brain regional differences in the effect of ethanol on GABA release from presynaptic terminals. Criswell HE, Ming Z, Kelm MK, Breese GR. J Pharmacol Exp Ther. 2008 Aug;326(2):596-603. Epub 2008 May 23.

Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous gamma-aminobutyric acid release onto cerebellum Purkinje neurons. Kelm MK, Criswell HE, Breese GR. J Pharmacol Exp Ther. 2007 Oct;323(1):356-64. Epub 2007 Jul 25.

Competing presynaptic and postsynaptic effects of ethanol on cerebellar purkinje neurons. Ming Z, Criswell HE, Yu G, Breese GR.  Alcohol Clin Exp Res. 2006 Aug;30(8):1400-7.

Basis of the gabamimetic profile of ethanol. Breese GR, Criswell HE, Carta M, Dodson PD, Hanchar HJ, Khisti RT, Mameli M, Ming Z, Morrow AL, Olsen RW, Otis TS, Parsons LH, Penland SN, Roberto M, Siggins GR, Valenzuela CF, Wallner M. Alcohol Clin Exp Res. 2006 Apr;30(4):731-44.