Research Interests
The Preclinical Psychogenetics Research Team
--Discovered that Inbred Fawn-Hooded rats voluntarily drank large amounts of alcohol, providing a strong genetic link in an animal model for alcohol preference and ability to drink large amounts of alcohol.
--Confirmed the association between the high voluntary consumption of saccharin as well as alcohol in alcohol-preferring rats, and established a similar relationship between sweet-liking and alcohol intake in humans.
--Found an ancient Chinese herbal medicine reduced alcohol intake in alcohol-preferring rats and alcohol-drinking monkeys.
---Isolated a pure compound from the Chinese herb which also reduced alcohol intake in rats. Recent Publications
Click here for a list of publications from PubMed
Patra B, Overstreet DH, Rezvani AH, Cleves M, Parsian A. Analysis of alcohol-related phenotypes in F2 progeny derived from FH/Wjd and ACI/N rat strains reveals independent measures and sex differences. Behav Brain Res. 2006 Dec 9.
Overstreet DH, Rezvani AH, Djouma E, Parsian A, Lawrence AJ. Depressive-like behavior and high alcohol drinking co-occur in the FH/WJD rat but appear to be under independent genetic control. Neurosci Biobehav Rev. 2007;31(1):103-14. 2006 Sep 18.
Overstreet DH, Rezvani AH, Cowen M, Chen F, Lawrence AJ. Modulation of high alcohol drinking in the inbred Fawn-Hooded (FH/Wjd) rat strain: implications for treatment. Addict Biol. 2006 Sep;11(3-4):356-73.
Overstreet DH, Knapp DJ, Angel RA, Navarro M, Breese GR. Reduction in repeated ethanol-withdrawal-induced anxiety-like behavior by site-selective injections of 5-HT (1A) and 5-HT (2C) ligands. Psychopharmacology (Berl). 2006 July; 187(1): 1-12.
Braw Y, Malkesman O, Dagan M, Bercovich A, Lavi-Avnon Y, Schroeder M, Overstreet DH, Weller A. Anxiety-like behaviors in pre-pubertal rats of the Flinders Sensitive Line (FSL) and Wistar-Kyoto (WKY) animal models of depression. Behav Brain Res. 2005 Nov 3.
Overstreet DH, Griebel G. Antidepressant-like effects of the vasopressin V1b receptor antagonist SSR149415 in the Flinders Sensitive Line rat. Pharmacol Biochem Behav. 2005 Sep;82(1):223-7. 2005 Sep 21.
Malkesman O, Braw Y, Maayan R, Weizman A, Overstreet DH, Shabat-Simon M, Kesner Y, Touati-Werner D, Yadid G, Weller A. Two Different Putative Genetic Animal Models of Childhood Depression.Biol Psychiatry. 2005 Aug 9.
Malkesman O, Braw Y, Zagoory-Sharon O, Golan O, Lavi-Avnon Y, Schroeder M, Overstreet DH, Yadid G, Weller A. Reward and anxiety in genetic animal models of childhood depression. Behav Brain Res. 2005 Oct 14;164(1):1-10.
Janowsky DS, Davis JM, Overstreet DH. Anticholinesterase (DFP) toxicity antagonism by chronic donepezil: a potential nerve agent treatment. Pharmacol Biochem Behav. 2005 Aug;81(4):917-22.
Padley JR, Overstreet DH, Pilowsky PM, Goodchild AK. Impaired cardiac and sympathetic autonomic control in rats differing in acetylcholine receptor sensitivity. Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H1985-92. 2005 Jun 10.
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Bowles Center for Alcohol Studies at the University of North Carolina at Chapel Hill