Bowles Center for Alcohol Studies
Departments of Psychiatry and Pharmacology
UNC Neuroscience Center, Curriculum in Neurobiology, and Curriculum in Toxicology
Neurosteroid and Ethanol Interactions (MERIT Award): The major goal of this project is to investigate the role of neuroactive steroids in ethanol action, tolerance and dependence.
Mechanisms of Addiction Pathogenesis The major goal of this project is to determine the molecular mechanisms that underlie chronic ethanol-induced adaptations of GABA-A receptors in brain and cultured cerebral cortical neurons.
Stress, Alcohol and GABAergic Neuroactive Steroids: The objective of this project is to elucidate the role of neuroactive steroids in the link between stress and excessive alcohol intake, including studies of neuroadaptive changes caused by chronic alcohol exposure.
Cellular GABAergic Neuroactive Steroid (3α,5α)-3-Hydroxy-Pregnan-20-One (3α,5α-THP) Immunostaining Levels Are Increased in the Ventral Tegmental Area of Human Alcohol Use Disorder Patients: A Postmortem Study. Hasirci AS, Maldonado-Devincci AM, Beattie MC, O'Buckley TK, Morrow AL. Alcohol Clin Exp Res. 2017 Feb;41(2):299-311. doi: 10.1111/acer.13300. PMID: 28068457
Initial genetic dissection of serum neuroactive steroids following chronic intermittent ethanol across BXD mouse strains. Porcu P, O'Buckley TK, Lopez MF, Becker HC, Miles MF, Williams RW, Morrow AL. Alcohol. 2017 Feb;58:107-125. doi: 10.1016/j.alcohol.2016.07.011. PMID: 27884493
Chronic Intermittent Ethanol Exposure Alters Stress Effects on (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP) Immunolabeling of Amygdala Neurons in C57BL/6J Mice. Maldonado-Devincci AM, Kampov-Polevoi A, McKinley RE, Morrow DH, O'Buckley TK, Morrow AL. Front Cell Neurosci. 2016 Mar 4;10:40. doi: 10.3389/fncel.2016.00040. PMID: 26973459
Ethanol Regulation of Synaptic GABAA α4 Receptors Is Prevented by Protein Kinase A Activation. Carlson SL, Bohnsack JP, Morrow AL. J Pharmacol Exp Ther. 2016 Apr;357(1):10-6. doi: 10.1124/jpet.115.230417. PMID: 26857960
Blunted neuroactive steroid and HPA axis responses to stress are associated with reduced sleep quality and negative affect in pregnancy: a pilot study. Crowley SK, O'Buckley TK, Schiller CE, Stuebe A, Morrow AL, Girdler SS. Psychopharmacology (Berl). 2016 Apr;233(7):1299-310. doi: 10.1007/s00213-016-4217-x. PMID:26856852