James C. Garbutt, M.D.

Professor J.C. Garbutt, M.D.
UNC Department of Psychiatry

Office | CB #7160
Email | jc_garbutt@med.unc.edu
Lab Website | Pharmacological Treatment of Alcoholism

 

 

Research Interests

My research interests involve several directions related to the biology of alcoholism and the development of new psychopharmacological strategies to treat alcoholism.

Relationship between Sweet Preference and Alcoholism
In collaboration with Dr. Alexey Kampov of the Center for Alcohol Studies we have extended an observation made in animals that preference for alcohol and preference for sweets are strongly correlated with one another by studying sweet preference in alcoholic men. Humans can be subdivided into sweet likers and sweet dislikers based on subjective responses to increasing concentrations of sugars. We have shown that 65% of abstinent male alcoholics without significant liver or pancreatic disease can be classified as sweet likers compared to 16% of nonalcoholic, similarly aged males. We are currently investigating the replicability of this finding, associated clinical variables and possible confounders such as altered taste or smell perception.

Baclofen for the Treatment of Alcohol Dependence
We are currently studying the efficacy and tolerability of baclofen, 30 mg/d, compared to placebo in men and women with alcohol dependence. Baclofen is a GABA-B agonist that has shown promise in animal models of heavy alcohol use and in one small human placebo-controlled trial where it reduced alcohol consumption and enhanced abstinence. We are also interested in developing a pilot study of combining baclofen with naltrexone for alcoholism.

Center Line Articles

  • Clinician Scientist Garbutt Translates Animal Research to Advances in Clinical Medicine (Vol 19, No 2)
  • Pharmacotherapy for Alcoholism: Coming of Age (Vol. 15, No. 3, 2004)
  • CAS Researchers Conduct a Clinical Trial of Extended Release Naltrexone (Vol. 13, No. 2, 2002)

Recent Publications

Click here for a list of publications from PubMed