Faculty & Research
Clyde Hodge, Ph.D.
Department of Psychiatry and Bowles Center for Alcohol Studies
Office | 1025A Thurston-Bowles Bldg, CB#7178
Email | firstname.lastname@example.org
Lab Website | Hodge Lab
Alcoholism is a complex neuropsychiatric disorder that is characterized by recurring cycles of chronic drinking, abstinence and relapse. Emerging evidence suggests that alcohol and other drugs of abuse may produce maladaptive changes in a variety of neurotransmitter, cell signaling and gene transcription pathways that lead to enduring changes in brain structure and function. These neuroadaptations are thought to regulate behavioral pathologies that occur in alcoholism.
The primary goals of our research are to 1) elucidate neuroadaptations in molecular signaling pathways associated with chronic voluntary alcohol drinking and abstinence; and 2) investigate the functional involvement of these molecular pathways in the behavioral effects of alcohol including self-administration, mood regulation (i.e., anxiety and depression), discrimination, and sensitization. Understanding the molecular mechanisms of drug-induced plasticity in brain and behavioral functions is of potential importance for development of new pharmacotherapies for problems associated with alcoholism, such as relapse.
Molecular Mechanisms of Ethanol Reinforcement
R01 AA014983; Hodge (PI)
The primary goal of this application is to characterize the involvement of metabotropic glutamate receptors in alcohol's reinforcing effects.
Molecular Mechanisms of Alcohol Drinking and Relapse
P60 AA011605; Component of UNC-CH Center Grant; Crews (PI), Hodge (Component PI)
This component of the NIAAA Alcohol Center Grant is focused on elucidating the functional involvement of the cell signaling pathways in alcohol drinking and relapse. Studies are focused on protein kinase C isoforms, the ERK/MAPK pathway, and how changes in activity of these kinases regulate alcohol drinking, relapse, and reinforcement.
Behavioral and Molecular Mechanisms of Ethanol-Induced Depression
R01 AA16629; Hodge (PI)
We have discovered that abstinence from chronic alcohol drinking is associated with increased depression-like behavior in mice. The goals of this multidisciplinary project are to identify molecular mechanisms of this alcohol-induced increase in depression.
Mentored Research Projects
Novel Mechanism of Ethanol Discrimination
K01 AA016009; Dr. Joyce Besheer (PI), Hodge (Mentor)
The primary goal of this project is to characterize neurobiological mechanisms of the subjective (i.e., discriminative) effects of alcohol.
Characterization of Adolescent Ethanol Sensitization
F31 AA016032; Rebekah Stevenson (PI), Hodge (Mentor)
The objective of this pre-doctoral research project is to examine developmental differences in neurobehavioral adaptation to repeated ethanol.
Ethanol Drinking, Depression, and Neurogenesis
F31 AA016043; Jennifer Hillmann (PI), Hodge (Mentor)
This pre-doctoral project is examining the effects of alcohol drinking on depression-like behavior with an emphasis on adult hippocampal neurogenesis as a potential mechanism.
Center Line Articles
Click for a list of publications from PubMed
Delayed developmental changes in neonatal vocalizations correlates with variations in ventral medial hypothalamus and central amygdala development in the rodent infant: Effects of prenatal cocaine. Cox ET, Hodge CW, Sheikh MJ, Abramowitz AC, Jones GF, Jamieson-Drake AW, Makam PR, Zeskind PS, Johns JM. Behav Brain Res. 2012 Aug 4. [Epub ahead of print]
Increased sensitivity to alcohol induced changes in ERK Map kinase phosphorylation and memory disruption in adolescent as compared to adult C57BL/6J mice. Spanos M, Besheer J, Hodge CW. Behav Brain Res. 2012 Apr 21;230(1):158-66. Epub 2012 Feb 13
Intra-amygdala inhibition of ERK(1/2) potentiates the discriminative stimulus effects of alcohol. Besheer J, Fisher KR, Cannady R, Grondin JJ, Hodge CW.Behav Brain Res. 2012 Mar 17;228(2):398-405. Epub 2011 Dec 23.
The effects of repeated corticosterone exposure on the interoceptive effects of alcohol in rats. Besheer J, Fisher KR, Grondin JJ, Cannady R, Hodge CW. Psychopharmacology (Berl). 2012 Apr;220(4):809-22. Epub 2011 Oct 21.
Intracranial self-stimulation in FAST and SLOW mice: effects of alcohol and cocaine. Fish EW, Robinson JE, Krouse MC, Hodge CW, Reed C, Phillips TJ, Malanga CJ. Psychopharmacology (Berl). 2012 Apr;220(4):719-30. Epub 2011 Oct 7.
Activation of group II metabotropic glutamate receptors inhibits the discriminative stimulus effects of alcohol via selective activity within the amygdala. Cannady R, Grondin JJ, Fisher KR, Hodge CW, Besheer J. Neuropsychopharmacology. 2011 Oct;36(11):2328-38. doi: 10.1038/npp.2011.121. Epub 2011 Jul 6.
Adolescent C57BL/6J mice show elevated alcohol intake, but reduced taste aversion, as compared to adult mice: a potential behavioral mechanism for binge drinking. Holstein SE, Spanos M, Hodge CW. Alcohol Clin Exp Res. 2011 Oct;35(10):1842-51. doi: 10.1111/j.1530-0277.2011.01528.x. Epub 2011 May 16.
Pregnenolone and ganaxolone reduce operant ethanol self-administration in alcohol-preferring p rats. Besheer J, Lindsay TG, O'Buckley TK, Hodge CW, Morrow AL. Alcohol Clin Exp Res. 2010 Dec;34(12):2044-52.
CRF-1 antagonist and CRF-2 agonist decrease binge-like ethanol drinking in C57BL/6J mice independent of the HPA axis. Lowery EG, Spanos M, Navarro M, Lyons AM, Hodge CW, Thiele TE. Neuropsychopharmacology. 2010 May;35(6):1241-52.
On the use of hyperpolarized helium MRI for conformal avoidance lung radiotherapy. Hodge CW, Tomé WA, Fain SB, Bentzen SM, Mehta MP. Med Dosim. 2010 Winter;35(4):297-303. Epub 2009 Oct 30.