Research Interests
Ethanol Regulation of GABA-A receptors
The primary goal of my project is to determine the molecular basis of ethanol induced adaptation of GABA-A receptors that influence the development of ethanol tolerance. There are many factors, including PKC, that may cause adaptation of GABA-A receptor following ethanol exposure. My research is focused on identifying the role of PKC that affects GABA-A receptor expression and function. I am interested in how ethanol affects PKC association with GABA-A receptors to alter receptor phosphorylation and trafficking. In addition, I am also investigating the effect of ethanol on PKC expression.
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Center Line Articles
Recent Publications
Click for a list of publications from PubMed
The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress. Kumar S, Porcu P, Werner DF, Matthews DB, Diaz-Granados JL, Helfand RS, Morrow AL. Psychopharmacology (Berl). 2009 May 20
Wilkie MB, Besheer J, Kelley SP, Kumar S, O'Buckley TK, Morrow AL, Hodge CW. Acute ethanol administration rapidly increases phosphorylation of conventional protein kinase C in specific mammalian brain regions in vivo. Alcohol Clin Exp Res. 2007 Jul;31(7):1259-67.
Sandeep Kumar, Brandon M. Lane, and A. Leslie Morrow. Differential effects of systemic ethanol administration on PKCε, g and β isoform expression, membrane translocation and target phosphorylation: Reversal by chronic ethanol exposure. J. Pharmacol. Exp. Ther. 319 (3): 1366-1375 (2006).
Kumar S, Khisti RT, Morrow AL. Regulation of native GABAA receptors by PKC and protein phosphatase activity. Psychopharmacology (Berl). 2005 Dec;183(2):241-7.
Khisti RT, Boyd KN, Kumar S, Morrow AL. Systemic ethanol administration elevates deoxycorticosterone levels and chronic ethanol exposure attenuates this response. Brain Res. 2005 Jul 5;1049(1):104-11.
Morrow AL, Ferrani-Kile K, Davis MI, Shumilla JA, Kumar S, Maldve R, Pandey SC. Ethanol effects on cell signaling mechanisms. Alcohol Clin Exp Res. 2004 Feb;28(2):217-27.
Kumar S, Fleming RL, Morrow AL. Ethanol regulation of gamma-aminobutyric acid A receptors: genomic and nongenomic mechanisms. Pharmacol Ther. 2004 Mar;101(3):211-26.
Khisti RT, Kumar S, Morrow AL. Ethanol rapidly induces steroidogenic acute regulatory protein expression and translocation in rat adrenal gland. Eur J Pharmacol. 2003 Jul 25;473(2-3):225-7.
Kumar S, Kralic JE, O'Buckley TK, Grobin AC, Morrow AL. Chronic ethanol consumption enhances internalization of alpha1 subunit-containing GABAA receptors in cerebral cortex. J Neurochem. 2003 Aug;86(3):700-8.
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Bowles Center for Alcohol Studies at the University of North Carolina at Chapel Hill