Research Interests
The Preclinical Psychogenetics Research Team
--Discovered that Inbred Fawn-Hooded rats voluntarily drank large amounts of alcohol, providing a strong genetic link in an animal model for alcohol preference and ability to drink large amounts of alcohol.
--Confirmed the association between the high voluntary consumption of saccharin as well as alcohol in alcohol-preferring rats, and established a similar relationship between sweet-liking and alcohol intake in humans.
--Found an ancient Chinese herbal medicine reduced alcohol intake in alcohol-preferring rats and alcohol-drinking monkeys.
---Isolated a pure compound from the Chinese herb which also reduced alcohol intake in rats. Recent Publications
Click here for a list of publications from PubMed
Simultaneous prenatal ethanol and nicotine exposure affect ethanol consumption, ethanol preference and oxytocin receptor binding in adolescent and adult rats.Williams SK, Cox ET, McMurray MS, Fay EE, Jarrett TM, Walker CH, Overstreet DH, Johns JM.Neurotoxicol Teratol. 2009 Jun 17
The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration. Licht CL, Marcussen AB, Wegener G, Overstreet DH, Aznar S, Knudsen GM.J Neurochem. 2009 Jun;109(5):1363-74.
Sensitization, duration, and pharmacological blockade of anxiety-like behavior following repeated ethanol withdrawal in adolescent and adult rats.Wills TA, Knapp DJ, Overstreet DH, Breese GR. Alcohol Clin Exp Res. 2009 Mar;33(3):455-63.
Abstinence from moderate alcohol self-administration alters progenitor cell proliferation and differentiation in multiple brain regions of male and female p rats.He J, Overstreet DH, Crews FT. Alcohol Clin Exp Res. 2009 Jan;33(1):129-38.
Tizabi Y, Getachew B, Rezvani AH, Hauser SR, Overstreet DH. Antidepressant-like effects of nicotine and reduced nicotinic receptor binding in the fawn-hooded rat, an animal model of co-morbid depression and alcoholism.Prog Neuropsychopharmacol Biol Psychiatry.
McMurray MS, Williams SK, Jarrett TM, Cox ET, Fay EE, Overstreet DH, Walker CH, Johns JM. Gestational ethanol and nicotine exposure: Effects on maternal behavior, oxytocin, and offspring ethanol intake in the rat. Neurotoxicol Teratol. 2008 Jul 11.
Overstreet DH, Cui CL, Ma YY, Guo CY, Han JS, Lukas SE, Lee DY. Electroacupuncture reduces voluntary alcohol intake in alcohol-preferring rats via an opiate-sensitive mechanism.Neurochem Res. 2008 Oct;33(10):2166-70.
Wills TA, Knapp DJ, Overstreet DH, Breese GR. Differential dietary ethanol intake and blood ethanol levels in adolescent and adult rats: effects on anxiety-like behavior and seizure thresholds.Alcohol Clin Exp Res. 2008 Aug;32(8):1350-60.
Braw Y, Malkesman O, Merenlender A, Bercovich A, Dagan M, Overstreet DH, Weller A. Withdrawal emotional-regulation in infant rats from genetic animal models of depression.Behav Brain Res. 2008 Nov 3;193(1):94-100.
Overstreet DH, Stemmelin J, Griebel G. Confirmation of antidepressant potential of the selective beta3 adrenoceptor agonist amibegron in an animal model of depression.Pharmacol Biochem Behav. 2008 Jun;89(4):623-6.
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Bowles Center for Alcohol Studies at the University of North Carolina at Chapel Hill