Research Interests
The Preclinical Psychogenetics Research Team
--Discovered that Inbred Fawn-Hooded rats voluntarily drank large amounts of alcohol, providing a strong genetic link in an animal model for alcohol preference and ability to drink large amounts of alcohol.
--Confirmed the association between the high voluntary consumption of saccharin as well as alcohol in alcohol-preferring rats, and established a similar relationship between sweet-liking and alcohol intake in humans.
--Found an ancient Chinese herbal medicine reduced alcohol intake in alcohol-preferring rats and alcohol-drinking monkeys.
---Isolated a pure compound from the Chinese herb which also reduced alcohol intake in rats. Recent Publications
Click here for a list of publications from PubMed
Novel medication targets for the treatment of alcoholism: preclinical studies. Rezvani AH, Lawrence AJ, Arolfo MP, Levin ED, Overstreet DH. Recent Pat CNS Drug Discov. 2012 Aug;7(2):151-62.
Modeling depression in animal models. Overstreet DH. Methods Mol Biol. 2012;829:125-44. Review.
Effects of a stressor and corticotrophin releasing factor on ethanol deprivation-induced ethanol intake and anxiety-like behavior in alcohol-preferring P rats.Knapp DJ, Overstreet DH, Huang M, Wills TA, Whitman BA, Angel RA, Sinnett SE, Breese GR. Psychopharmacology (Berl). 2011 Nov;218(1):179-89. Epub 2011 Jun 4.
Cytokine involvement in stress may depend on corticotrophin releasing factor to sensitize ethanol withdrawal anxiety. Knapp DJ, Whitman BA, Wills TA, Angel RA, Overstreet DH, Criswell HE, Ming Z, Breese GR. Brain Behav Immun. 2011 Jun;25 Suppl 1:S146-54. Epub 2011 Mar 4.
Fear induced neuronal alterations in a genetic model of depression: an fMRI study on awake animals. Huang W, Heffernan ME, Li Z, Zhang N, Overstreet DH, King JA. Neurosci Lett. 2011 Feb 4;489(2):74-8. Epub 2010 Dec 4.
Hepatic drug metabolizing profile of Flinders Sensitive Line rat model of depression. Kotsovolou O, Ingelman-Sundberg M, Lang MA, Marselos M, Overstreet DH, Papadopoulou-Daifoti Z, Johanson I, Fotopoulos A, Konstandi M. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1075-84. Epub 2010 Jun 4.
Interactions of stress and CRF in ethanol-withdrawal induced anxiety in adolescent and adult rats. Wills TA, Knapp DJ, Overstreet DH, Breese GR. Alcohol Clin Exp Res. 2010 Sep 1;34(9):1603-12. Epub 2010 Jun 25.
Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression. Overstreet DH, Naimoli VM, Griebel G. Pharmacol Biochem Behav. 2010 Aug;96(2):206-10. Epub 2010 May 12.
Pro-apoptotic Par-4 and dopamine D2 receptor in temporal cortex in schizophrenia, bipolar disorder and major depression. Glantz LA, Gilmore JH, Overstreet DH, Salimi K, Lieberman JA, Jarskog LF. Schizophr Res. 2010 May;118(1-3):292-9. Epub 2010 Jan 13.
Nerve growth factor (NGF) has novel antidepressant-like properties in rats. Overstreet DH, Fredericks K, Knapp D, Breese G, McMichael J. Pharmacol Biochem Behav. 2010 Feb;94(4):553-60. Epub 2009 Nov 27.
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Bowles Center for Alcohol Studies at the University of North Carolina at Chapel Hill