Our laboratory applies molecular, biochemical, genetic and genomics approaches to understanding the mechanisms of environmental agent-related organ injury and carcinogenesis. Specifically, we are interested in nuclear receptor-mediated pathways in chemical carcinogenesis, oxidative DNA damage and repair, the role that alcohol and diet play in cancer, and the genetic determinants of the susceptibility to toxicant-induced liver injury. Through a combination of in vivo animal studies and experiments that utilize cellular and molecular models, we aim to better understand why certain chemicals cause cancer or organ damage in rodents and whether humans in general, or any susceptible sub-population in particular, are at risk from similar exposures.
Center Line Articles
Click here for a list of publications from PubMed
Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism. Tryndyak V, Conti AD, Kobets T, Kutanzi K, Koturbash I, Han T, Fuscoe JC, Latendresse JR, Melnyk S, Shymonyak S, Collins L, Ross SA, Rusyn I, Beland FA, Pogribny IP. FASEB J. 2012 Aug 7. [Epub ahead of print]
Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet. Tryndyak VP, Latendresse JR, Montgomery B, Ross SA, Beland FA, Rusyn I, Pogribny IP. Toxicol Appl Pharmacol. 2012 Jul 1;262(1):52-9. Epub 2012 Apr 24.
Predictive modeling of chemical hazard by integrating numerical descriptors of chemical structures and short-term toxicity assay data. Rusyn I, Sedykh A, Low Y, Guyton KZ, Tropsha A. Toxicol Sci. 2012 May;127(1):1-9.
Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Tsuchiya M, Ji C, Kosyk O, Shymonyak S, Melnyk S, Kono H, Tryndyak V, Muskhelishvili L, Pogribny IP, Kaplowitz N, Rusyn I. Hepatology. 2012 Jul;56(1):130-9.
Computational tools for discovery and interpretation of expression quantitative trait loci. Wright FA, Shabalin AA, Rusyn I. Pharmacogenomics. 2012 Feb;13(3):343-52.
Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Lock EF, Abdo N, Huang R, Xia M, Kosyk O, O'Shea SH, Zhou YH, Sedykh A, Tropsha A, Austin CP, Tice RR, Wright FA, Rusyn I. Toxicol Sci. 2012 Apr;126(2):578-88.
Joint effects of alcohol consumption and polymorphisms in alcohol and oxidative stress metabolism genes on risk of head and neck cancer. Hakenewerth AM, Millikan RC, Rusyn I, Herring AH, North KE, Barnholtz-Sloan JS, Funkhouser WF, Weissler MC, Olshan AF. Cancer Epidemiol Biomarkers Prev. 2011 Nov;20(11):2438-49.
Predicting drug-induced hepatotoxicity using QSAR and toxicogenomics approaches. Low Y, Uehara T, Minowa Y, Yamada H, Ohno Y, Urushidani T, Sedykh A, Muratov E, Kuz'min V, Fourches D, Zhu H, Rusyn I, Tropsha A. Chem Res Toxicol. 2011 Aug 15;24(8):1251-62.
MicroRNA expression in the livers of inbred mice. Gatti DM, Lu L, Williams RW, Sun W, Wright FA, Threadgill DW, Rusyn I. Mutat Res. 2011 Sep 1;714(1-2):126-33.
Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene. Koturbash I, Scherhag A, Sorrentino J, Sexton K, Bodnar W, Swenberg JA, Beland FA, Pardo-Manuel Devillena F, Rusyn I, Pogribny IP. Toxicol Sci. 2011 Aug;122(2):448-56.