Services

Knockout Mouse Services
The Animal Models Core produces knockout mice, conditional knockout mice, knockin mice, etc. by gene targeting in embryonic stem cells. We offer full-service packages as well as ad-hoc services to meet our clients' needs.
Transgenic Mouse Services
The Animal Models Core offers a full range of pronuclear injection services for production of transgenic mice. Transgenic mouse production is available in C57BL/6, FVB and B6D2 strains. Transgenic injections can also be performed in custom strains provided by the client. Transgene cloning and BAC recombineering services are available for production of transgenes.
Transgenic and Knockout Rat Services
The Animal Models Core offers a full range of rat genetic modification services including pronuclear microinjection for production of transgenic rats using plasmid or BAC transgenes and production of knockout/knockin rats by injection of CRISPR/Cas9 nucleases.
BAC Recombineering Services
The Animal Models Core offers a full range of BAC recombineering services
Reproductive Services
We offer reproductive services including sperm and embryo cryopreservation, strain resuscitation from frozen embryos, strain rederivation, in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Contact the core director for more information.