Project CRASH

crash

Project CRASH was a cohort study examining genotypic and phenotypic characteristics associated with the recovery process after motor vehicle collision. Patients experiencing motor vehicle collision were enrolled in the study at emergency department study sites in Alabama, Florida, Massachusetts, Michigan, North Carolina, New York, and Washington DC. Study participants completed a baseline assessment in the ED, as well as a follow-up interview, 6-week interview, 6-month, and 1-year, following the motor vehicle collision. This study was funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR056328). Dr. McLean is PI of this study.

Status: closed

The goal of the African American CRASH Study was to perform an initial evaluation of ethnic differences in the recovery process after motor vehicle collision. The parent grant, Project CRASH, provides data from a large European American cohort. In addition, a pilot cohort of African Americans experiencing MVC had been enrolled. Data collected shows that living in a disadvantaged neighborhood influences chronic pain development after motor vehicle collision.

 Status: closed

The Older Adult CRASH Study was the first prospective study to examine outcomes in older adults after motor vehicle collision not requiring hospitalization. The study enrolled patients over the age of 65 from Project CRASH study sites. The Older Adult CRASH study will provides a better understanding of how the recovery process after motor vehicle collision differs in elderly vs. non-elderly individuals. This project was supported by a career development award (5KL2RR025746-03) granted to Tim Platts-Mills, MD through UNC’s Translational and Clinical Sciences Institute. Dr. Platts-Mills is the PI of this study.

 Status: closed

Related Publications, Abstracts, and Presentations

 Refereed Articles and Publications

  1. McLean SA.  Neurobiologic mechanisms of whiplash. In. Troels S. Jensen, Dennis Turk, and Helge Kasch (ed):  Whiplash injury:  Perspectives on the development of chronic pain. Philadelphia: IASP press 2016, 155-169.
  2. Linnstaedt SD, Riker KD, Walker MG, Nyland JE, Zimny E, Lewandowski C, Hendry PL, Damiron K, Pearson C, Velilla MA, Jones J, Swor RA, Domeier R, McLean SA. microRNA-320a predicts chronic axial and widespread pain development following motor vehicle collision in a stress-dependent manner. JOSPT. In Press July 2016.
  3. Wang X, Xie H, Cotton AS, Brickman KR, Lewis TL, Wall JT, Tamburrino MB, Bauer WR, Law K, McLean SA, Liberzon I. Early changes in emotion processing circuits after mild traumatic brain injury from motor vehicle collision. Accepted Journal of Neurotrauma 05/03/2016
  4. Platts-Mills TF, Nicholson RJ, Richmond NL, Patel KV, Simonsick EM, Domeier RM, Swor RA, Hendry PL, Peak DA, Rathlev NK, Jones JS,  Lee DC, Weaver MA, Keefe FJ, McLean SA. Restricted Activity and Persistent Pain following Motor Vehicle Collision among Older Adults: a Multicenter Prospective Cohort Study. Accepted BMC Geriatrics 4/11/16.
  5. Meloto CB, Bortsov AV, Bair E, Helgeson ES, Ostrom C, Smith SB, Dubner R, Slade GD, Fillingim RB, Greenspan JD, Ohrbach R, Maixner W, McLean SA, Luda Diatchenko, MD. Modification of COMT-dependent pain sensitivity by psychological stress and sex. Accepted PAIN 11/20/15
  6. Hu J, Bortsov AV, Ballina LE, Orrey DC, Swor RA, Peak D, Jones J, Rathlev N, Lee DC, Domeier R, Hendry P, McLean SA. Chronic widespread pain after motor vehicle collision typically occurs via immediate development and non-recovery: results of an emergency department-based cohort study. Accepted for publication 10/8/15 Pain.
  7. Linnstaedt SD, Bortsov AV, Soward AC, Swor R, Peak D, Jones J, Rathlev N, Lee DC, Domeier R, Hendry P, McLean SA. CRHBP polymorphisms predict chronic pain development following motor vehicle collision. Accepted for publication 9/25/15 Pain. PMID:26447706
  8. Auvergne L, Bortsov AV, Ulirsch JC, Peak DA, Jones JS, Swor RA, Domeier RM, Lee DC, Rathlev NK, Hendry PL, McLean SA. Association of epidemiologic factors and genetic variants influencing HPA axis function with “Post-Concussive Symptoms” after minor motor vehicle collision. Accepted 8/15 Psychosomatic Medicine.
  9. Linnstaedt SD, Walker MG, Parker JS, Yeh E, Sons RL, Zimny E, Lewandowski C, Hendry PL, Damiron K, Pearson C, Velilla MA, O’Neil BJ, Jones JS, Swor RA, Domeier R, Hammond S, McLean SA. microRNA circulating in the early aftermath of motor vehicle collision predict persistent pain development and suggest a role for microRNA in sex-specific pain differences. Mol Pain. 2015;11:66.  PMID: 26498117
  10. Platts-Mills TF, Flannigan SA, Bortsov AV, Smith S, Domeier RM, Swor RA, Hendry PL, Peak DA, Rathlev NK, Jones JS,  Lee DC, Keefe FJ, Sloane PD, McLean SA. Persistent pain among older adults discharged home from the emergency department after motor vehicle crash: a prospective study. Ann Emerg Med. 2015. PMID:26092559
  11. Linnstaedt SD, Hu J, Bortsov AV, Soward AC, Swor RA, Jones JS, Lee DC, Peak DA, Domeier RM, Rathlev NK, Hendry PL, McLean SA. µ-Opioid Receptor Gene A118G variants and persistent pain symptoms among men and women experiencing motor vehicle collision. J Pain 6(7):637-44, 2015. PMID: 25842347
  12. Wang X, Xie H, Cotton AS, Tamburrino MB, Brickman KR, Lewis TL, McLean SA, Liberzon I. Early cortical thickness changes after mild traumatic brain injury following motor vehicle collision. J Neurotrauma. 2015:32(7):455-63. PMID: 25118568
  13. Pereira GF, McLean SA, Tkacik TJ, Swor RA, Jones JS, Lee DC, Peak DA, Domeier RM, Rathlev NK, Hendry PL, Platts-Mills TF. Pain, distress, and anticipated recovery for older versus younger emergency department patients after motor vehicle collision. BMC Emergency Medicine. 2014;14:25. PMID: 25547869
  14. Musey PI, Linnstaedt SD, Platts-Mills TF, Miner JR, Bortsov AV, Safdar B, Bijur P, Rosenau A, Tsze DS, Chang AK, Dorai S, Engel K, Feldman JA, Fusaro AM, Lee DC, Rosenberg M, Keefe FJ, Peak DA, Nam CS, Patel R, Fillingim RB, McLean SA. Gender Differences in Acute and Chronic Pain in the Emergency Department: Results of the 2014 Society for academic emergency medicine consensus conference pain section. Acad Emerg Med. 21(12):1421-30, 2014. PMID: 25422152
  15. Qadri YJ, Bortsov AV, Orrey DC, Swor RA, Peak DA, Jones JS, Rathlev NK, Lee DC, Domeier RM, Hendry PL, McLean SA. Genetic polymorphisms in the dopamine receptor 2 predict acute pain severity after motor vehicle collision. Clin J Pain. 2014 Nov 3. PMID: 25370144
  16. Hunold KM, Sochor MR, McLean SA, Mosteller KB, Fernandez AR, Platts-Mills TF. Ambulance transport rates after motor vehicle collision for older vs. younger adults: a population-based study. Accid Anal Prev. 2014;73:373-9. PMID: 25310339
  17. Kessler RC, Rose S, Koenen KC, Karam EG, Stang PD, Stein DJ, Heeringa SG, Hill ED, Liberzon I, McLaughlin KA, McLean SA, Pennell BE, Petukhova M, Rosellini AJ, Ruscio AM, Shahly V. Shalev AY, Silove D, van Ommeren M, Zaslavsky AM, Angermeyer MC, Bromet EJ, Caldas de Almeida JM, de Girolamo G, de Jonge P, Demyttenaere K, Florescu SE, Gureje O, Haro JM, Hinkov H, Kawakami N, Kovess-Masfety V, Lee S, Medina-Mora ME, Murphy SD, Navarro-Mateu F, Piazza M, Posada-Villa J, Scott K, Torres Y, Viana MC. How well can post-traumatic stress disorder be predicted from pre-trauma risk factors? An exploratory study in the WHO World Mental Health Surveys. World Psychiatry. 2014;13:265-74. PMID: 25273300
  18. Ulirsch JC, Weaver MA, Bortsov A, Soward AC, Swor RA, Peak DA, Jones JS, Rathlev NK, Lee DC, Domeier RM, Hendry PL, McLean SA. No man is an island: living in a disadvantaged neighborhood influences chronic pain development after motor vehicle collision, and this effect is moderated by common genetic variation influencing HPA axis function. Pain. 155(10):2116-23, 2014. PMID: 25107859
  19. Lewis GC, Platts-Mills TF, Swor R, Peak D, Jones J, Rathlev N, Lee DC, Domeier R, Hendry P, McLean SA. Incidence and predictors of acute psychological distress and dissociation after motor vehicle collision: a cross-sectional study. J Trauma Dissociation. 15(5):527-47, 2014. PMID: 24983475
  20. Bortsov AV, Platts-Mills TF, Peak DA, Jones JS, Swor RA, Domeier RM, Lee DC, Rathlev NK, Hendry PL, Fillingim RB, McLean SA. Effect of pain location and duration on life function in the year after motor vehicle collision. Pain 155(9):1836-45, 2014. PMID: 24972071
  21. McLean SA, Ulirsch JC, Slade GD, Soward AC, Swor RA, Peak DA, Jones JS, Rathlev NK, Lee DC, Domeier RM, Hendry PL, Bortsov AV, Bair E. incidence and predictors of neck and widespread pain after motor vehicle collision among US litigants and non-litigants. Pain 155(2), 309-321, 2014. PMID: 24145211
  22. Bortsov AV, Diatchenko L, McLean SA. Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision. Neuromolecular Med. 16(1):83-93. 2014. PMID: 23963787
  23. Bortsov AV, Smith JE, Diatchenko L, Soward AC, Ulirsch JC, Rossi C, Swor RA, Hauda WE, Peak DA, Jones JS, Holbrook D, Rathlev NK, Foley KA, Lee DC, Collette R, Domeier RM, Hendry PL, McLean SA. Polymorphisms in the glucocorticoid receptor co-chaperone FKBP5 predict persistent musculoskeletal pain after traumatic stress exposure. Pain 154(8): 1419-1426, 2013. PMID: 23707272
  24. Bortsov AV, Platts-Mills TF, Peak DA, Jones JS, Swor RA, Domeier RM, Lee DC, Rathlev NK, Hendry PL, Fillingim RB, McLean SAPain distribution and predictors of widespread pain in the immediate aftermath of motor vehicle collision. Eur J Pain 17(8): 1243-1251, 2013. PMID: 23335385
  25. Lee YM, Platts-Mills TF, MacWilliams JB, Sochor MR, Jones JS, Domeier RM, Schneider LW, McLean SA. Descriptions of motor vehicle collisions by participants in emergency department–based studies: are they accurate? West J Emerg Med.13(4): 329-334, 2012. PMID: 22942933
  26.  Platts-Mills, T.F., Hunold, K.M., Esserman, D.A., Sloane, P.D., McLean, S.A. (2012). Motor vehicle collision-related emergency department visits by older adults in the United States. Academic Emergency Medicine, 19, 821-7. PMCID: 373587.
  27. Platts-Mills, T.F., Esserman DA, Brown DL, Bortsov AV, Sloane PD, McLean SA. (2012). Older US emergency department patients are less likely to receive pain medication than younger patients: results from a national survey. Annals of Emergency Medicine, 60. 199-206. PMCID: 3338876.
  28. Platts-Mills, T.F., Lee, Y.M., Swor, R.A., Zaleski, E.Z., Clauw, D.J., McLean, S.A. (2012). Pain and interference of pain with function and mood in older adults involved in a motor vehicle collision: a pilot study. Experimental Aging Research, 38. 330-43.
  29. Platts-Mills, T.F., Ballina, L., Bortsov, A.V., Soward, A., Swor, R.A., Jones, J.S., Lee, D.C., Peak, D.A., Domeier, R.M., Rathlev, N.K., Hendry, P.L., McLean, S.A. (2011). Using emergency department-based inception cohorts to determine genetic characteristics associated with long term patient outcomes: methodology of the CRASH study. BMC Emergency Medicine, 11, 14-19. PMCID: 3188467.
  30. Platts-Mills TF, Hunold K, Ballina L, Bortsov AV, Peak DA, Jones JS, Swor RA, Lee DC, Domeier RM, Hendry PL, Rathlev NK, McLean SAMore Educated Emergency Department Patients are Less Likely to Receive Opioids for Acute Pain.  Pain 153(5):941-2, 2012.
  31. McLean SA. The Potential Contribution of Stress System Responses to the Transition to Chronic Whiplash-Associated Disorders.  Spine 36:S226-32, 2011.
  32. Platts-Mills TF, Ballina L, Bortsov AV, Soward A, Swor RA, Jones JS, Lee DC, Peak DA, Domeier RM, Rathlev NK, Hendry PL, McLean SA. Using Emergency Department-Based Inception Cohorts to Determine Genetic Characteristics Associated with Long Term Patient Outcomes: Methodology of the CRASH Study. BMC Emergency Medicine 2011.
  33. Sterling M, McLean SA, Sullivan MJ, Elliott J, Butenhuis J, Kamper SJ.  Potential processes involved in the initiation and maintenance of Whiplash Associated Disorders (WAD).  Spine 36:S322-9, 2011.
  34. Lee YM, Platts-Mills TF, MacWilliams J, Jones JS, Domeier RM, Swor RA, Sochor MA, Schneider J, McLean SA. Description of Motor Vehicle Collisions by Participants in Emergency Department-Based Studies: Are they Accurate?  West J Emerg Med. 2011 (in press).
  35. McLean SA, Diatchenko L, Lee YM, Swor RA, Domeier RM, Jones JS, Jones CW, Reed C, Harris RE, Maixner W, Clauw DJ, Liberzon I.  Catechol O-methyltransferase haplotype predicts immediate musculoskeletal neck pain and psychological symptoms after minor motor vehicle collision.  Journal of Pain 12(1):101-7, 2011.
  36. Lee DC, McLean S, Barton E, Hahn SJ. Variations in local institutional Review Boards (IRB) responses to a standard, multi-center, emergency department-based genetic research project. Academic Emergency Medicine. 2010:17(5):S(1)S140-141.

Published Abstracts and Presentations

  1. Lateef B, Liu AY, Hu J, MO Martel, RR Edwards, Swor RA, Peak DA, Jones JS, Rathlev NK, Lee DC, Domeier RM, Hendry PL, McLean SA. Pain Catastrophizing as a Predictor of Opioid Administration in Patients Presenting to the Emergency Department (ED) After Motor Vehicle Collision (MVC) 1(1), 14 Presented at the Annual Meeting of the American Pain Society, Palm Springs, CA, May 2015.
  2. Wang X, Xie H, Brickman KR, Bazerbashi MF, Tamburrino MB, McLean SA, Liberzon I. Early changes in cortical emotion processing circuits after mild traumatic brain injury following motor vehicle collision. Presented at the 2016 Military Health System Research Symposium.
  3. Nicholson RJ, Hunold KM, Weaver MA, Lytle LA, Keefe FJ, McLean SA, Platts-Mills TF. Effect of Reduced Physical Activity on the Development of Persistent Pain After Motor Vehicle Collision in Older Adults: a Propensity Score-Matched Analysis. Presented at the Annual Meeting of the Society of Academic Emergency Medicine, 2015.
  4. Flannigan SA, Bortsov AV, Swor RA, Jones JS, Lee DC, Peak DA, Domeier RM, Rathlev NK, Hendrey PL, McLean SA, Platts-Mills TF. Derivation of a Simple Clinical Prediction Instrument to Identify Older Adults at Increased Risk of Persistent Pain after Motor Vehicle Collision. Presented at the Annual Meeting of the Society for Academic Emergency Medicine, 2015.
  5. Linnstaedt SD, Yeh E, Walker MG, Sons RL, Zimny E, Lewandowski C, Hendry PL, Damiron K, Pearson C, Velilla MA, Jones J, Swor R, Domeier R, McLean SA. MicroRNA in whole blood as predictors of severe axial pain development following motor vehicle collision trauma.  Presented at the Annual Meeting of the American Society for Anesthesiology, San Diego, CA, Oct 2015.
  6. Linnstaedt SD, Riker KD, Nyland JE, Zimny E, Lewandowski C, Hendry PL, Damiron K, Pearson C, Velilla MA, Jones J, Swor R, Domeier R, McLean SA. microRNA 320a is a potential mediator of chronic widespread hyperalgesia development after stress exposure. J Pain 4(16), S40(#239) Presented at the Annual  Meeting of the American Pain Society, Palm Springs, CA, May 2015.
  7. Liu AY, Hu J, Platts-Mills TF, Lateef B, Qadri YJ, Wang HE, Velilla MA, Pearson C, Zimny E, Lewandowski C, Hendry PL, Damiron K, Domeier RM, Kaushik S, Feldman JA, Jones JS, Villard MA, McLean SA. Education status is not associated with opioid medication receipt among African American emergency department patients with acute pain. J  Pain 16(4):S32, (#224) Presented at the Annual Meeting of the American Pain Society, Palm Springs, CA, May 2015.
  8. Villard MA, Beaudoin FL, Hu J, Orrey D, Peak DA, Jones JS, Swor RA, Domeier RM, Lee DC, Rathlev NK, Hendry PL, McLean SA. Few individuals at high risk of persistent musculoskeletal pain after motor vehicle collision receive early psychological or physiotherapy intervention. J Pain, 16(4):S33, (#230) Presented at the Annual Meeting of the American Pain Society, Palm Springs, CA, May 2015.44.
  9. Lateef B, Liu AY, Hu J, MO Martel, RR Edwards, Swor RA, Peak DA, Jones JS, Rathlev NK, Lee DC, Domeier RM, Hendry PL, McLean SA. Pain Catastrophizing as a Predictor of Opioid Administration in Patients Presenting to the Emergency Department (ED) After Motor Vehicle Collision (MVC) 1(1), 14 Presented at the Annual Meeting of the American Pain Society, Palm Springs, CA, May 2015.
  1. Beaudoin FL, Gutman R, Peak DA, Jones JS, Swor RA, Domeier RM, Lee DC, Rathlev NK, Hendry PL, McLean SA. Treatment effects of opioids versus NSAIDs prescribed from the emergency department following motor vehicle crash: the impact on pain outcomes at 6 weeks. J Pain , 16(4):S79,(#412) Presented at the Annual Meeting of the American Pain Society, Palm Springs, CA,  May 2015.
  2. Hu J, Bollen KA, Lane ST, Bortsov AV, Peak DA, Jones JS, Swor RA, Domeier RM, Lee DC, Rathlev NK, Hendry PL, McLean SA. Evaluation of the influence of stress-induced pain vulnerability and sociodemographic characteristics on acute pain after a motor vehicle collision using structural equation modeling. 4(16), S1 Presented at American Pain Society Meeting ,Palm Springs, CA 2015.
  3. Hu J, Kessler RC Bortsov AV, Battles SR*, Peak DA, Jones JS, Swor RA, Domeier R, Lee DC, Rathlev NK, Hendry PL, McLean SA. Evaluating musculoskeletal pain pathogenesis in the aftermath of motor vehicle collision in a multi-dimensional context. Presented at American Pain Society Meeting, Tampa, FL, 2014
  4. Duval ER, Wang X, Cotton AS, Xie H, Ramanujam V, Ho S, Brickman KR, Tamburrino M, McLean SA, Liberzon I.  Neural Mechanisms underlying Emotion Modulation during Recovery from Acute Stress [abstract]. Neuropsychopharmacology, 39, S1, (M218), 2014. Presented at the American College of Neuropsychopharmacology annual meeting, Phoenix, AZ.
  5. Feinberg RK, Weaver MA, Liberzon I, Swor RA, Peak DA, Jones JS, Rathlev NK, Lee DC, Domeier RM, Hendry PL, McLean SA. Stress-Related Psychological Symptoms Contribute to Neck Pain Persistence after Motor Vehicle Collision: Path Analysis Results from A Prospective Longitudinal Study [abstract]. J Pain, 15 (4), S35, (#239). Presented at American Pain Society Meeting, Tampa, FL, 2014. Awarded second place for best meeting abstract in psychosocial domain.
  6. Bermudez AL, Hu J, Bortsov AV, Soward AC, Swor RA, Peak DA, Jones JS, Rathlev NK, Lee DC, Domeier RM, Hendry PL, Linnstaedt SD, McLean SA. Obesity increases the risk of persistent moderate or severe neck pain 6 months after motor vehicle collision [abstract]. J Pain, 15 (4), S35, (#235). Presented at the Annual Meeting of the American Pain Society, Tampa, FL, May 2014.
  7. Nichols J, Hu J, Soward AC, Swor RA, Peak DA, Jones JS, Rathlev NK, Lee DC, Domeier RM, Hendry PL, Liberzon I,  McLean SA. Not so great expectations: characteristics associated with negative expectations of physical and emotional recovery in the hours after motor vehicle collision [abstract]. J Pain, 15 (4), S35, (#238). Presented at the Annual Meeting of the American Pain Society, Tampa, FL, May 2014.
  8. Hu J, Bortsov AV, Soward AC, Swor RA, Peak DA, Jones JS, Rathlev NK, Lee DC, Domeier RM, Hendry PL, Platts-Mills TF, Linnstaedt SD, McLean SA. Most widespread pain present 1 year after motor vehicle collision (MVC) begins in the early aftermath of the MVC: results of a multicenter prospective cohort study [abstract]. J Pain, 15 (4), @35, (#237). Presented at the Annual Meeting of the American Pain Society, Tampa, FL, May 2014.
  9. Bortsov AV, Miller WC, Soward AC, Swor RA, Peak DA, Jones JS, Rathlev NK, Lee DC, Domeier RM, Hendry PL, McLean SA. Derivation of an emergency department-based clinical prediction tool to identify individuals at increased risk of chronic musculoskeletal pain development after motor vehicle collision [abstract]. J Pain, 15 (4), S12 (#145). Presented at the Annual Meeting of the American Pain Society, Tampa, FL, May 2014.
  10. Liu AY, Bermudez AL, Hu J, Jones S, Hwang J, Smith JE, Ballina LE, Patel A, Tran T, Karlnoski T, Smith DJ, Cairns B, McLean SA. African Americans Are at Increased Risk of Developing Chronic Pain and Itch at the Site of Tissue Autograft Following Major Thermal Burn Injury [abstract]. J Pain, 15 (4), S35 (#236). Presented at the Annual Meeting of the American Pain Society, Tampa, FL, May 2014.
  11. Bortsov AV, Swift-Scanlan T, Diatchenko L, Swor RA, Peak DA, Jones JS, Rathlev NK, Lee DC, Domeier RM, Hendry PL, McLean SA. Variable DNA methylation in genes involved in immune response is a potential predictor of chronic widespread pain after motor vehicle collision [abstract]. J Pain, 15 (4), S34, (#268). Presented at the Annual Meeting of the American Pain Society, Tampa, FL, May 2014. Selected as Top 1% of abstracts by American Pain Society Pain Genetics Committee
  12. Linnstaedt SD, Walker MG, Parker JS, Sons RL, Velilla MA, Pearson C, O’Neil BJ, Zimny E, Lewandowski C, Damiron K, Hendry PL, Barnes S, Rosenberg M, Hammond SM, McLean SA. Circulating microRNA evaluated in the early aftermath of motor vehicle collision predict widespread pain development in African Americans and provide potential pathogenic insights: results of a preliminary analysis [abstract]. J Pain, 15 (4), S43, (#269). Presented at the Annual Meeting of the American Pain Society, Tampa, FL, May 2014. Selected as best meeting abstract by American Pain Society Pain Genetics Committee.
  13. Linnstaedt SD, Walker MG, Bortsov AV, Swor RA, Jones JS, Lee DC, Peak DA, Domeier RM, Rathlev NK, McLean SA. The ADRA2A genetic variant rs3750635 influences extent and severity of acute pain after motor vehicle collision and may do so by regulating microRNA function [abstract]. J Pain, 15 (4), S44, (#272). Presented at the Annual Meeting of the American Pain Society, Tampa, FL, May 2014.
  14. Platts-Mills TF, Pereira G, Isenberg E, Weaver M, Swor RA, Jones JS, Lee DC, Peak DA, Domeier RM, Rathlev NK, Hendry PL, McLean SA. Older adults with persistent musculoskeletal pain after motor vehicle collision are at increased risk of functional decline: a prospective longitudinal study [abstract]. J Pain, 15 (4), S31, (#223). Presented at the Annual Meeting of the American Pain Society, Tampa, FL, May 2014.
  15. Xie H, Wall J, Liberzon I, Tamburrino M, Cotton A, Custer A, McLean SA, Brickman K, Bauer W, Wang X. Subacute cortical thickness changes after mild traumatic brain injury [abstract]. Biological Psychiatry 75 (9), S102 (#321). Selected for presentation at the Annual Meeting of the Society of Biological Psychiatry, New York, NY, May 2014.
  16. Wang X, Duval ER, Cotton AS, Ho S, Brickman KR, Tamburrino MB, McLean SA, Bauer WR, Liberzon I. Medial prefrontal cortex involvement in emotional threat processing following motor vehicle collision. Presented at the Annual Meeting of the Society for Neuroscience, San Diego, CA, November 2013. Abstract retrieved from 2013 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2013. Online.
  17. Auvergne L, Ulirsch JC, Bortsov A, Peak DA, Jones JS, Swor RA, Domeier RM, Lee DC, Rathlev NK, McLean SA. Gene Variants Influencing the Stress Response, Not Head Injury, Predict Post-Concussive Symptom Severity After MVC. Presented at the 2013 American Society of Anesthesiologists meeting, October 12-16, 2013, San Francisco, CA. Abstract retrieved from Abstracts in American Society of Anesthesiology database (A1251).
  18. Bortsov AV, Linnstaedt SD, Swor RA, Peak DA, Rathlev NK, Lee DC, Domeier RM, Hendry PL, Jones JS, McLean SA. Genetic variants affecting CRH-binding protein predict pain persistence after trauma exposure. Presented at the 2013 American Society of Anesthesiologists meeting, October 12-16, 2013, San Francisco, CA. Abstract retrieved from Abstracts in American Society of Anesthesiology database (BO S09). Selected as a conference "top abstract"
  19. Bortsov A, Diatchenko L, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domeier R, Hendry P, McLean SA. COMT haplotypes predict pain intensity and interference 6 weeks after motor vehicle collision [abstract]. J Pain, 14 (4), S42, (#267). Presented at the Annual Meeting of the American Pain Society, New Orleans, LA, May 2013.
  20. Adasme RA, Platts-Mills TF, Fillingim R, Swor R, Jones J, Lee D, Peak D, Domeier R, Rathlev N, Hendry P, McLean SA. Fear of movement in the early aftermath of a motor vehicle collision is an independent predictor of pain interference at six weeks [abstract]. J Pain, 14 (4), S15, (#157). Presented at the Annual Meeting of the American Pain Society, New Orleans, LA, May 2013.
  21. Ulirsch J, Bortsov A, Soward A, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domeier R, Hendry P, McLean SA. No man is an island: living in a more disadvantaged neighborhood increases the likelihood of developing persistent moderate or severe neck pain 6 weeks after motor vehicle collision [abstract]. J Pain, 14 (4), S101, (#502). Presented at the Annual Meeting of the American Pain Society, New Orleans, LA, May 2013. Also presented as oral presentation at Society of Academic Emergency Medicine annual meeting, Atlanta, GA, May 2013. *Selected as top abstract ("Gallery of Excellence") - top 12% of abstracts.
  22. Soward A, Ulirsch J, Bair E, Slade G, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domeier R, Hendry P, McLean SA. Risk factors for persistent pain after motor vehicle collision differ between litigants and non-litigants [abstract]. J Pain, 14 (4), S29, (#214). Presented at the Annual Meeting of the American Pain Society, New Orleans, LA, May 2013.
  23. Verma N, Platts-Mills TF, Hunold K, Swor R, Peak D, Lee D, Jones J, Rathlev N, Domeier R, Hendry P, McLean SA. Initial neuropathic pain symptoms predict musculoskeletal pain severity six weeks after MVC [abstract]. J Pain, 14 (4), S19, (#172). Presented at the Annual Meeting of the American Pain Society, New Orleans, LA, May 2013.
  24. Linnstaedt S, Bortsov A, Swor R, Jones J, Lee D, Peak D, Domeier R, Rathlev N, Hendry P, McLean SA. Among women with substantial peritraumatic distress after minor motor vehicle collision (MVC), the presence of one or more G alleles at OPRM1 A118G is protective against developing persistent moderate or severe pain [abstract]. J Pain, 14 (4), S42, (#266). Presented at the Annual Meeting of the American Pain Society, New Orleans, LA, May 2013.
  25. Orrey DC, Ulirsch J, Linnstaedt S, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domeier R, Hendry P, McLean SA. Interactions between gender and other risk factors are associated with persistent neck pain after motor vehicle collision [abstract]. J Pain, 14 (4), S17, (#166). Presented at the Annual Meeting of the American Pain Society, New Orleans, LA, May 2013.
  26. Platts-Mills TF, Matthews S, Pereira G, Fillingim R, Swor R, Jones J, Lee D, Peak D, Domeier R, Rathlev N, Hendry P, McLean SA. Age-related differences in recovery from pain due to motor vehicle collision: a prospective longitudinal study [abstract]. J Pain, 14 (4), S13, (#149). Presented at the Annual Meeting of the American Pain Society, New Orleans, LA, May 2013.
  27. Qadri YJ, Bortsov AV, Swor RA, Peak DA, Jones JS, Rathlev NK, Lee DC, Domeier RM, Hendry PL, Mclean SA. Genetic polymorphisms in the Dopamine Receptor D2 are associated with acute pain severity after motor vehicle collision.  Accepted to the 2012 Annual Meeting of the American Society of Anesthesiologists. **Selected for oral presentation in the 2012 ASA "Best Abstracts" session.
  28. Goetzinger A, Orrey D, Lee Y, Platts-Mills T, Bortsov, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domeier R, Hendry P, Liberzon I, McLean S.  Persistent Neck Pain is Associated with Increased Risk of significant PTSD and Depressive Symptoms and Greater Health Service Utilization 6 Weeks after Motor Vehicle Collision.  Accepted for poster presentation at the International Association of the Study of Pain's Bi-Annual World Congress on Pain, Milan, Italy, August 2012.
  29. Smith JE, Ulirsch J, Bortsov A, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domeier R, Hendry P, Diatchenko, McLean S.  FKBP5 Variants Predict Neck Pain Persistence Six Weeks After Motor Vehicle Collision.  Accepted for poster presentation at the International Association of the Study of Pain's Bi-Annual World Congress on Pain, Milan, Italy, August 2012. Selected for oral presentation at the 2012 Annual Meeting of the American Society of Anesthesiologists.
  30. Lewis GC, Platts-Mills TF, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domeier R, Hendry P, McLean SA. Incidence and predictors of psychological distress after motor vehicle collision. Presented at the Society for Academic Emergency Medicine Annual Conference, Chicago, IL 2012. **Selected for oral presentation in special "Future Stars of Emergency Medicine" session.
  31. Ballina L, Diatchenko L, Ulirsch J, Bortsov A, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domieir R, Hendry P, Liberzon I, McLean SA. Sexually Dimorphic Influence of COMT on Distress in the Immediate Aftermath of Trauma. Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012
  32. Bortsov A, Soward A, Diatchenko L, Ulirsch J, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domieir R, Hendry P, Liberzon I, McLean SA. Tryptophan Hydroxylase 2 Synonymous Polymorphism rs7305115 is Associated with Acute Psychological Response after Motor Vehicle Collision. Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012
  33. Smith J, Bortsov A, Ulirsch J, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domieir R, Hendry P, Liberzon I, McLean SA.  FKBP5 Polymorphism Predicts Peritraumatic Dissociation after Motor Vehicle Collision. Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012  **Scored in the top 1% of all abstracts submitted to conference and received a Top Poster Finalist award.
  34. Ulirsch J, Bortsov A, Smith J, Diatchenko L, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domieir R, Hendry P, Liberzon I, McLean SA. ADRA2A Variants Predict Peritraumatic Dissociation After Motor Vehicle Collision. Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012
  35. Goetzinger A, Orrey D, Lee Y, Platts-Mills T, Bortsov A, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domieir R, Hendry P, Liberzon I, McLean SA. Peritraumatic Psychological Distress and Mild Traumatic Brain Injury Symptoms (MTBI) are Associated in the Early Aftermath of Trauma. Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012. ** Scored in the top 1% of all abstracts submitted to conference and received a Top Poster Finalist award.
  36. Platts-Mills T, Ballina L, Diatchenko L, Bortsov A, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domieir R, Hendry P, Liberzon I, McLean SA. Influence of COMT HPS Haplotype on Peritraumatic Distress Severity among Women Experiencing Motor Vehicle Collision: Report of an Age x Gene Interaction.  Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012.
  37. Xie H, Tamburrino M, Dennis M, Elhai J, Brickman K, Liberzon I, McLean S, Wall J, Bauer W, Wang X.  Relationships Between Brain Structural Properties and Acute Pain and Stress After a Motor Vehicle Accident. Presented at the Annual Meeting of the Society for Neuroscience, Washington, DC, 2011.
  38. Whittington K, Bortsov A, Soward AC, Jones J, Peak D, Swor R, Lee D, Rathlev N, Domeier R, Hendry P, Maixner W, Slade G, McLean SA. A pain in the neck? Which regions of body pain are most associated with pain interference and other health outcomes 6 weeks after motor vehicle collision. Presented at the Annual Meeting of the APS, Austin, TX, 2011, and the Annual Meeting of the Society of Academic Emergency Medicine, Boston, MA, 2011.
  39. Bortsov A, Whittington K, Lee Y, Soward AC, Jones J, Peak D, Swor R, Lee D, Rathlev N, Domeier R, McLean SA. Individual vulnerability factors, but not collision-related factors, are associated with extent of moderate or severe pain symptoms in the immediate aftermath of motor vehicle collision. Presented at the Annual Meeting of the American Pain Society, Austin, TX, 2011.
  40. Lee Y, Orrey D, Bortsov A, Whittington K, Jones J, Peak D, Swor R, Lee D, Rathlev N, Domeier R, Maixner W, Slade G, Fillingim R, McLean SA. Shared Vulnerability to pain and post-concussive syndrome in the early aftermath of motor vehicle collision. Presented for Presentation at the Annual Meeting of the American Pain Society, Austin, TX, 2011.
  41. Edwards L, Mitchell P, Jones J, Hendry P, Peak D, Swor R, Lee D, Rathlev N, Domeier R, Bortsov A, Platts-Mills T, Fillingim R, McLean SA. Increased catastrophizing and reduced recovery expectations in the early aftermath of motor vehicle collision among African Americans vs. European Americans. Presented at the Annual Meeting of the American Pain Society, Austin, TX, 2011.
  42. Ballina L, Platts-Mills T, Jones J, Peak D, Swor R, Soward AC, Whittington K, Lee D, Rathlev N, Domeier R, Orrey D, Liberzon I, McLean SA. Receipt of mental health care services in the initial weeks after motor vehicle collision is rare among patients with persistent neck pain and substantial co-morbid PTSD symptoms. Presented at the Annual Meeting of the American Pain Society, Austin, TX, 2011.
  43. Halawa OI, Mclean SA, Lee YM, Platts-mills TF, Zaleski E, Withrow A, Clauw DJ, Liberzon I. Elevated Cortisol Levels after Motor Vehicle Collision Predict Post Traumatic Stress Disorder and Depressive Symptoms at 1 Month. Presented at the annual meeting of the Society for Biological Psychiatry, New Orleans, LA, 2010.
  44. Roane BM, Orrey D, Soward AC, Swor RA, Liberzon I, Clauw DJ, McLean SA. Pain and psychological symptom differences in African Americans and European Americans experiencing motor vehicle collision. Presented at the annual meeting of the American Pain Society, Baltimore, MD, 2010.
  45. Swor RA, Lee YM, McLean SA. Spinal board immobilization may be associated with persistent pain after Motor Vehicle Crash. National Association of EMS Physicians, Phoenix, AZ 2010.