Burn Experiences

The recovery process following a thermal burn is not well understood. The purpose of this pilot study is to examine patient characteristics associated with immediate and long term patient outcomes after major burn injury. This study is being conducted at burn centers within the Burn TRYUMPH Research Network (renamed, UNC Institute for Trauma Recovery). This project is supported by the UNC CTRC, The Jaycee Burn Center, and the Department of Anesthesiology.

Status: closed

Study Sites and Network

burn experiences study map

 

Publications, Abstracts, and Presentations

Refereed Publications

  1. Mauck M, Villard MA, Liu AY, Jones S, Hwang J, Williams F, Shupp J, Karlnoski R, Smith D, Bien M, Jia E, Bruce C, Ji R, McLean SA. Association between pain and itch symptom severity after major thermal burn injury increases over time, The Journal of Pain, Volume 17, Issue 4 Supplement, Page S37, April 2016, ISSN 1526-5900
  2. Nyland JE, McLean SA, Loyd DL. Prior stress exposure increases pain behaviors in a rat model of full thickness thermal injury. Accepted for publication 9/9/15 BURNS. PMID: 26432505
  3. Orrey DC, Halawa OI, Bortsov AB, Shupp JW, Jones SW, Haith LR, Hoskins JM, Jordan MH, Bangdiwala S, Roane BM, Platts-Mills TF, Holmes JH, Hwang J, Cairns BA, McLean SA. Results of a pilot multi-centered genotype-based randomized placebo-controlled trial of propranolol to reduce pain after major thermal burn injury. Clin J Pain. 31(1):21-9, 2015. PMID: 25084070
  4. Orrey DC, Bortsov AV, Hoskins JM, Shupp JW, Jones SW, Cicuto BJ, Hwang J, Jordan MH, Holmes JH, Haith LR, Roane BM, Diatchenko L, Cairns BA, McLean SACatechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients. Accepted Journal of Burn Care and Research.

Refereed Abstracts

  1. Villard MA, Mauck M, Liu AY, Jones S, Hwang J, Williams F, Shupp J, Karlnoski R, Smith D, Doshi N, Jallah D, Cairns B, McLean SA. PTSD influences pain and itch symptoms overtime following MThBI. Presented at the Annual Meeting of the American Pain Society, Austin, TX, 2016.
  2. Mauck MC, Villard MA, Liu AY, Jones S, Hwang J, Williams F, Shupp J, Karlnoski R, Smith D, Bien M, Jia E, Cairns B, Ji RR, McLean SA. Association between pain and itch symptom severity after major thermal burn injury increases over time. Presented at the Annual Meeting of the American Pain Society, Austin, TX, 2016.
  3. Nyland JE, Mclean SA, Averitt DL. Combined serotonin and norepinephrine reuptake inhibition reduces the effects of stress on post-injury pain behaviors in a rat model of burn injury. J Pain 16(4):S66 Presented at the Annual Meeting of the American Pain Society, Palm Springs, CA, May 2015.
  4. Mauck MC, Liu AY, Bortsov AV, Jones S, Hwang J, Williams FN, Shupp JW, Karlnoski T, Smith DJ, Krishnan A, Wesp B, Gellatly M, Cairns B, McLean SA. Predictors of pain severity after major thermal burn injury vary according to phase of burn wound healing. 16(4), (#229). J Pain, Presented at the Annual Meeting of the American Pain Society, Palm Springs, CA, May 2015.
  5. Orrey D, Bortsov A, Shupp J, Jones S, Hwang J, Jordan M, Holmes J, Haith L, Cairns B, Liberzon I, McLean SA. Individuals with Elevated PTSD Symptoms Experience Increased Itch Symptom Morbidity after Major Burn Injury. Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012.
  6. Orrey D, Bortsov A, Liberzon I, Shupp JW, Jones S, Hwang J, Jordan MH, Holmes J, Haith L, Cairns B, McLean SA. Failure of propranolol to decrease anxiety and PTSD symptoms in a genotype-based RCT of patients with major thermal burn injury. Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012.
  7. Orrey DC, Zhao S, Bair E, Bortsov AV, Shupp JW, Jones SW, Hwang J, Jordan MH, Holmes JH, Haith LR, Cairns BA, McLean, SA. Smokers Experience Increased Pain and Itch After Major Burn Injury.  Presented at the annual meeting of the American Burn Association, Seattle, WA, 2012.
  8. Tomecka M, Orrey D, Bortsov A, Shupp J, Jordan M, Jones S, Holmes J, Haith L, Cairns B, McLean SA.  Itch Symptoms are Strongly Associated with Pain Symptoms in Patients with Major Thermal Burn Injury. Accepted for poster presentation at the Annual Meeting of the American Society of Anesthesiologists, Chicago, IL, 2011.
  9. Orrey DC, Shupp J, Jones SW, Cicuto B, Jordan M, Holmes J, Haith L, Cairns B, McLean SA. Results of a Pilot Multi-centered RCT of Propranolol to Decrease Pain in Admitted Burn Patients.  Accepted for poster presentation at the Annual Meeting of the American Society of Anesthesiologists, Chicago, IL, 2011.
  10. Orrey DC, Bortsov A, Shupp J, Cicuto B, Jordan M, Holmes J, Haith L, Cairns B, McLean SA.  Catechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients. Presented at the Annual Meeting of the American Society of Anesthesiologists, Chicago, IL, 2011.
  11. Orrey D, Shupp J, Hoskins J, Platts-Mills T, Bortsov A, Bangdiwala S, Haith L, Diatchenko L, Holmes J, Jordan M, Cairns B, McLean SA. Pilot multicenter, genotype-based, randomized, double-blind, placebo-controlled trial of propranolol to reduce initial pain symptoms in patients with major burn injury. Presented at the Annual Meeting of the American Pain Society, Austin, TX, 2011.
  12. Orrey DC, Shupp J, Hoskins JM, Platts-Mills TF, Bortsov AV, Bangdiwala SI, Jones SW, Cicuto BJ, Haith LR, Diatchenko L, Holmes JH, Jordan MH, Cairns BA, McLean SA. Feasibility and Acceptability of a Genotype-Specific Randomized Controlled Trial (RCT) of Pain Treatment in a Research Network Burn Center Population. Presented at the annual meeting of the American Burn Association in Chicago, IL, 2011.
  13. Halawa O, Roane BM, Orrey D, Whittington K, Soward AC, Jones S, Cairns B, McLean SA. Feasibility and acceptability of a genotype-specific RCT of pain treatment in a burn population. Presented at the Annual Meeting of the American Society of Anesthesiologists, San Diego, CA, 2010.