European American Motor Vehicle Collision Cohort (McLean, PI)

  1. Project CRASH is a prospective cohort study examining genotypic and phenotypic characteristics associated with the recovery process after motor vehicle collision. Patients experiencing motor vehicle collision are enrolled in the study at emergency department study sites in Michigan, Massachusetts, New York, and Florida. Study participants complete a baseline assessment in the ED as well as a follow-up interview 6 weeks, 6 months, and 1 year following the motor vehicle collision. This study is funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR056328). Dr. McLean is PI of this study.

Status: enrollment has ended; analysis in progress

Study Sites and Networks

Project Crash Sites

 

Publications, Abstracts and Presentations


Related Publications

 

  1. A Bortsov, T Swift-Scanlan, L Diatchenko, R Swor, D Peak, J Jones, N Rathlev,D Lee, R Domeier, P Hendry, and S McLean; Association of Individual and Collision-Related Characteristics with Extent of Pain in the Early Aftermath of Motor Vehicle Collision, Journal of Pain, April 2014
  2. J Hu, A Bortsov, A Soward, R Swor, D Peak, J Jones, N Rathlev, D Lee, R Domeier, P Hendry, T Platts-Mills, S Linnstaedt, and S McLean; Most Widespread Pain Present 1 Year after Motor Vehicle Collision (MVC) Begins within Weeks of the MVC: Results of a Multicenter Prospective Cohort Study, Journal of Pain, 2014
  3. A Bortsov, W Miller, A Soward, R Swor, D Peak, J Jones, N Rathlev, D Lee, R Domeier, P Hendry, and S McLean,Derivation of an emergency department-based clinical prediction tool to identify individuals at increased risk of chronic axial pain development after motor vehicle collision. Journal of Pain, S12, April 2014. 

  4. S Linnstaedt,M Walker, A Bortsov, R Swor, D Peak, J Jones, D Lee, R Domeier, N Rathlev, and S McLean, The ADRA2A genetic variant rs3750635 influences extent and severity of acute pain after motor vehicle collision, and may do so by regulating microRNA function,  Journal of Pain,  April 2014
  5. Bortsov AV, Platts-Mills TF, Peak DA, Jones JS, Swor RA, Domeier RM, Lee DC, Rathlev NK, Hendry PL, Fillingim RB, McLean SA. Pain distribution and predictors of widespread pain in the immediate aftermath of motor vehicle collision. Accepted Eur J Pain.
  6. Platts-Mills TF, Hunold K, Bortsov AV, Peak DA, Jones JS, Swor RA, Lee DC, Domeier RM, Hendry PL, Rathlev NK, McLean SA. More Educated Emergency Department Patients are Less Likely to Receive Opioids for Acute Pain. Pain 153(5):941-2, 2012.
  7. McLean SA. The Potential Contribution of Stress System Responses to the Transition to Chronic Whiplash-Associated Disorders.  Spine 36:S226-32, 2011.
  8. Platts-Mills TF, Ballina L, Bortsov AV, Soward A, Swor RA, Jones JS, Lee DC, Peak DA, Domeier RM, Rathlev NK, Hendry PL, McLean SA. Using Emergency Department-Based Inception Cohorts to Determine Genetic Characteristics Associated with Long Term Patient Outcomes: Methodology of the CRASH Study. BMC Emergency Medicine 2011.
  9. Sterling M, McLean SA, Sullivan MJ, Elliott J, Butenhuis J, Kamper SJ.  Potential processes involved in the initiation and maintenance of Whiplash Associated Disorders (WAD).  Spine 36:S322-9, 2011.
  10. Lee YM, Platts-Mills TF, MacWilliams J, Jones JS, Domeier RM, Swor RA, Sochor MA, Schneider J, McLean SA. Description of Motor Vehicle Collisions by Participants in Emergency Department-Based Studies: Are they Accurate?  West J Emerg Med. 2011 (in press).
  11. McLean SA, Diatchenko L, Lee YM, Swor RA, Domeier RM, Jones JS, Jones CW, Reed C, Harris RE, Maixner W, Clauw DJ, Liberzon I.  Catechol O-methyltransferase haplotype predicts immediate musculoskeletal neck pain and psychological symptoms after minor motor vehicle collision.  Journal of Pain 12(1):101-7, 2011.
  12. Lee DC, McLean S, Barton E, Hahn SJ. Variations in local institutional Review Boards (IRB) responses to a standard, multi-center, emergency department-based genetic research project. Academic Emergency Medicine. 2010:17(5):S(1)S140-141.

 


Related Abstracts

  1. A Bortsov, T Swift-Scanlan, L Diatchenko, R Swor, D Peak, J Jones, N Rathlev, D Lee, R Domeier, P Hendry, and S McLean; Variable DNA methylation in genes involved in the immune response is a potential predictor of chronic widespread pain after motor vehicle collision. Presented at the Annual Meeting of the American Pain Society, Tampa, FL, 2014.
  2. Feinberg RK, Weaver MA, Liberzon I, Swor RA, Peak DA, Jones JS, Rathlev NK, Lee DC, Domeier RM, Hendry PL, McLean SA. Stress-Related Psychological Symptoms Contribute to Axial Pain persistence after Motor Vehicle Collision: Analysis Results from a Prospective Longitudinal Study. Presented at the Annual Meeting of the American Pain Society, Tampa, FL, 2014.
  3. S Linnstaedt, M Walker, A Bortsov, R Swor, D Peak, J Jones, D Lee, R Domeier, N Rathlev, and S McLean, The ADRA2A genetic variant rs3750635 influences extent and severity of acute pain after motor vehicle collision, and may do so by regulating microRNA function. Presented at the Annual Conference of the American Pain Society, Tampa, FL, 2014.
  4. Bermudez AL, Hu J, Bortsov AV, Soward AC, Swor RA, Peak DA, Jones JS, Rathlev NK, Lee DC, Domeier RM, Hendry PL, Linnstaedt SD, McLean SA. Obesity increases the risk of persistent moderate or severe neck pain 6 months after motor vehicle collision. Accepted for presentation at the Annual Meeting of the American Pain Society, Tampa, FL, May 2014.
  5. Bortsov AV, Miller WC, Soward AC, Swor RA, Peak DA, Jones JS, Rathlev NK, Lee DC, Domeier RM, Hendry PL, McLean SA. Derivation of an emergency department-based clinical prediction tool to identify individuals at increased risk of chronic musculoskeletal pain development after motor vehicle collision. Accepted for presentation at the Annual Meeting of the American Pain Society, Tampa, FL, May 2014.
  6. J Hu, A Bortsov, A Soward, R Swor, D Peak, J Jones, N Rathlev, D Lee, R Domeier, P Hendry, T Platts-Mills, S Linnstaedt, and S McLean, Most Widespread Pain Present 1 Year after Motor Vehicle Collision (MVC) Begins within Weeks of the MVC: Results of a Multicenter Prospective Cohort Study. Presented at the Annual Meeting of the American Pain Society, Tampa, FL, 2014.
  7. J Nichols, J Hu, A Soward, R Swor, D Peak, J Jones, N Rathlev, D Lee, R Domeier, P Hendry, I Liberzon, and S McLean. Not So Great Expectations: Characteristics Associated with Negative Expectations of Physical and Emotional Recovery in the Hours after Motor Vehicle Collision. Presented at the Annual Meeting of the American Pain Society, Tampa, FL, 2014.
  8. Orrey DC, Ulirsch J, Linnstaedt S, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domeier R, Hendry P, McLean S. Interactions between gender and other risk factors are associated with persistent neck pain after motor vehicle collision. Presented at the Annual Meeting of the American Pain Society, New Orleans, LA, 2013.
  9. Linnstaedt SD, Bortsov AV, Swor R, Jones J, Lee D, Peak D, Domeier R, Rathlev N, Hendry P, McLean SA. Among women with substantial peritraumatic distress after minor motor vehicle collision (MVC), the presence of one or more G alleles at OPRM1 A118G is protective against developing persistent moderate or severe pain. Presented at the Annual Meeting of the American Pain Society, New Orleans, LA, 2013.
  10. Bortsov AV, Diatchenko L, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domeier R, Hendry P, McLean SA. COMT haplotypes predict pain intensity and interference 6 weeks after motor vehicle collision. Presented at the Annual Meeting of the American Pain Society, New Orleans, LA, 2013.
  11. Soward AC, Ulirsch JC, Bair E, Slade G, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domeier R, Hendry P, McLean SA. Risk factors for persistent pain after motor vehicle collision differ between litigants and non-litigants. Presented at the Annual Meeting of the American Pain Society, New Orleans, LA, 2013.
  12. Orrey DC, Ulirsch JC, Linnstaedt SD, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domeier R, Hendry P, McLean SA. Interactions between gender and other risk factors are associated with persistent neck pain after motor vehicle collision. Presented at the Annual Meeting of the American Pain Society, New Orleans, LA, 2013.
  13. Ulirsch JC, Bortsov AV, Soward AC, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domeier R, Hendry P, McLean SA. No Man is An Island: living in a more disadvantaged neighborhood increases the likelihood of developing persistent moderate or severe neck pain 6 weeks after motor vehicle collision. Presented at the Annual Meeting of the American Pain Society, New Orleans, LA, 2013.
  14. Adasme RA, Platts-Mills TF, Fillingim R, Swor R, Jones J, Lee D, Peak D, Domeier R, Rathlev N, Hendry P, McLean SA. Fear of movement in the early aftermath of a motor vehicle collision is an independent predictor of pain interference at six weeks. Presented at the Annual Meeting of the American Pain Society, New Orleans, LA, 2013.
  15. Verma N, Platts-Mills TF, Hunold K, Swor RA, Peak DA, Jones JS, Rathlev NK, Lee DC, Domeier RM, Hendry P, McLean SA. Initial neuropathic pain symptoms predict musculoskeletal pain severity six weeks after motor vehicle collision. Presented at the Annual Meeting of the American Pain Society, New Orleans, LA, 2013.
  16. Qadri YJ, Bortsov AV, Swor RA, Peak DA, Jones JS, Rathlev NK, Lee DC, Domeier RM, Hendry PL, Mclean SA. Genetic polymorphisms in the Dopamine Receptor D2 are associated with acute pain severity after motor vehicle collision.  Accepted to the 2012 Annual Meeting of the American Society of Anesthesiologists. **Selected for oral presentation in the 2012 ASA "Best Abstracts" session.
  17. Qadri YJ, Bortsov AV, Swor RA, Peak DA, Jones JS, Rathlev NK, Lee DC, Domeier RM, Hendry PL, Mclean SA. Genetic polymorphisms in the Dopamine Receptor D2 are associated with acute pain severity after motor vehicle collision. Accepted to the 2012 Annual Meeting of the American Society of Anesthesiologists. **Selected for oral presentation in the 2012 ASA "Best Abstracts" session.
  18. Smith JE, Ulirsch J, Bortsov A, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domeier R, Hendry P, Diatchenko, McLean S. FKBP5 Variants Predict Neck Pain Persistence Six Weeks After Motor Vehicle Collision. Accepted for poster presentation at the International Association of the Study of Pain's Bi-Annual World Congress on Pain, Milan, Italy, August 2012. Selected for oral presentation at the 2012 Annual Meeting of the American Society of Anesthesiologists.
  19. Lewis GC, Platts-Mills TF, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domeier R, Hendry P, McLean SA. Incidence and predictors of psychological distress after motor vehicle collision. Presented at the Society for Academic Emergency Medicine Annual Conference, Chicago, IL 2012. **Selected for oral presentation in special "Future Stars of Emergency Medicine" session.
  20. Ballina L, Diatchenko L, Ulirsch J, Bortsov A, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domieir R, Hendry P, Liberzon I, McLean SA. Sexually Dimorphic Influence of COMT on Distress in the Immediate Aftermath of Trauma. Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012
  21. Bortsov A, Soward A, Diatchenko L, Ulirsch J, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domieir R, Hendry P, Liberzon I, McLean SA. Tryptophan Hydroxylase 2 Synonymous Polymorphism rs7305115 is Associated with Acute Psychological Response after Motor Vehicle Collision. Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012
  22. Smith JE, Ulirsch J, Bortsov A, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domeier R, Hendry P, Diatchenko, McLean S. FKBP5 Variants Predict Neck Pain Persistence Six Weeks After Motor Vehicle Collision. Accepted for poster presentation at the International Association of the Study of Pain's Bi-Annual World Congress on Pain, Milan, Italy, August 2012. Selected for oral presentation at the 2012 Annual Meeting of the American Society of Anesthesiologists.
  23. Ulirsch J, Bortsov A, Smith J, Diatchenko L, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domieir R, Hendry P, Liberzon I, McLean SA. ADRA2A Variants Predict Peritraumatic Dissociation After Motor Vehicle Collision. Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012
  24. Goetzinger A, Orrey D, Lee Y, Platts-Mills T, Bortsov A, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domieir R, Hendry P, Liberzon I, McLean SA. Peritraumatic Psychological Distress and Mild Traumatic Brain Injury Symptoms (MTBI) are Associated in the Early Aftermath of Trauma. Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012. ** Scored in the top 1% of all abstracts submitted to conference and received a Top Poster Finalist award.
  25. Platts-Mills T, Ballina L, Diatchenko L, Bortsov A, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domieir R, Hendry P, Liberzon I, McLean SA. Influence of COMT HPS Haplotype on Peritraumatic Distress Severity among Women Experiencing Motor Vehicle Collision: Report of an Age x Gene Interaction.  Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012.
  26. Xie H, Tamburrino M, Dennis M, Elhai J, Brickman K, Liberzon I, McLean S, Wall J, Bauer W, Wang X.  Relationships Between Brain Structural Properties and Acute Pain and Stress After a Motor Vehicle Accident. Presented at the Annual Meeting of the Society for Neuroscience, Washington, DC, 2011.
  27. Whittington K, Bortsov A, Soward AC, Jones J, Peak D, Swor R, Lee D, Rathlev N, Domeier R, Hendry P, Maixner W, Slade G, McLean SA. A pain in the neck? Which regions of body pain are most associated with pain interference and other health outcomes 6 weeks after motor vehicle collision. Presented at the Annual Meeting of the APS, Austin, TX, 2011, and the Annual Meeting of the Society of Academic Emergency Medicine, Boston, MA, 2011.
  28. Bortsov A, Whittington K, Lee Y, Soward AC, Jones J, Peak D, Swor R, Lee D, Rathlev N, Domeier R, McLean SA Individual vulnerability factors, but not collision-related factors, are associated with extent of moderate or severe pain symptoms in the immediate aftermath of motor vehicle collision. Presented at the Annual Meeting of the American Pain Society, Austin, TX, 2011.
  29. Lee Y, Orrey D, Bortsov A, Whittington K, Jones J, Peak D, Swor R, Lee D, Rathlev N, Domeier R, Maixner W, Slade G, Fillingim R, McLean SA. Shared Vulnerability to pain and post-concussive syndrome in the early aftermath of motor vehicle collision. Presented for Presentation at the Annual Meeting of the American Pain Society, Austin, TX, 2011.
  30. Edwards L, Mitchell P, Jones J, Hendry P, Peak D, Swor R, Lee D, Rathlev N, Domeier R, Bortsov A, Platts-Mills T, Fillingim R, McLean SA. Increased catastrophizing and reduced recovery expectations in the early aftermath of motor vehicle collision among African Americans vs. European Americans. Presented at the Annual Meeting of the American Pain Society, Austin, TX, 2011.
  31. Ballina L, Platts-Mills T, Jones J, Peak D, Swor R, Soward AC, Whittington K, Lee D, Rathlev N, Domeier R, Orrey D, Liberzon I, McLean SA. Receipt of mental health care services in the initial weeks after motor vehicle collision is rare among patients with persistent neck pain and substantial co-morbid PTSD symptoms. Presented at the Annual Meeting of the American Pain Society, Austin, TX, 2011.
  32. Halawa OI, Mclean SA, Lee YM, Platts-mills TF, Zaleski E, Withrow A, Clauw DJ, Liberzon I. Elevated Cortisol Levels after Motor Vehicle Collision Predict Post Traumatic Stress Disorder and Depressive Symptoms at 1 Month. Presented at the annual meeting of the Society for Biological Psychiatry, New Orleans, LA, 2010.
  33. Roane BM, Orrey D, Soward AC, Swor RA, Liberzon I, Clauw DJ, McLean SA. Pain and psychological symptom differences in African Americans and European Americans experiencing motor vehicle collision. Presented at the annual meeting of the American Pain Society, Baltimore, MD, 2010.
  34. Swor RA, Lee YM, McLean SA. Spinal board immobilization may be associated with persistent pain after Motor Vehicle Crash. National Association of EMS Physicians, Phoenix, AZ 2010.

Conference Locations


Photos

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Dr. Andrey Bortsov presenting results at the Society of Biological Psychiatry, Philadelpha, PA 2012

 

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Clinical Psychologist, Dr. Amy Goetzinger presenting results at the Society of Biological Psychiatry, Philadelpha, PA 2012
Dr. Goetzinger's received a blue ribbon for presenting one of the best (top 5%) of posters at SOBP!

 

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Dorris Duke Fellow, Dr. Jennifer Smith presents results at the American Society of Anesthesiologists, Washington DC, 2012

Bortsov AV, Platts-Mills TF, Peak DA, Jones JS, Swor RA, Domeier RM, Lee DC, Rathlev NK, Hendry PL, Fillingim RB, McLean SA. Pain distribution and predictors of widespread pain in the immediate aftermath of motor vehicle collision. Accepted Eur J Pain.