We provide our trainees with a rigorous grounding in the basic principles of molecular and thermodynamic descriptions of macromolecules through the 650 series of four intense, 1.5 credit modules taken by all trainees. Beyond that, trainees choose at least three courses from a series of twelve 1 and 2 credit modules (the 660 series) that teach the fundamentals of different methods for investigating the structure and function of macromolecules. These allow trainees to establish a solid theoretical and practical (some have both lab and lecture components) background in the particular areas of Biophysics relevant to their individual training goals. Research Rotations performed during the first year of training provides trainees opportunities both to obtain additional practical experience and to identify potential laboratories for their thesis research. Finally, our Training Program prepares trainees to be successful in the highly collaborative atmosphere of modern bioscience. All our courses are organized into Work Groups in which trainees do assignments in a collaborative fashion. This encourages trainees from diverse basic disciplines (cell biology to physics) to work together and learn from each other as well as attack problems in an interdisciplinary fashion. Our seminar course not only introduces trainees to research that spans the broad range of modern biophysics, but also helps them develop the oral communication skills critical to their professional success.