2008 Fall Seminars

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"CIB1 Signaling in Cardiovascular Disease and Cancer" (408 Mary Ellen Jones, from September 09, 2008 11:00 AM to September 09, 2008 12:00 PM)

Leslie V. Parise, PhD

"The Role of Flexible Loops in Enzymatic Catalysis" (*Pagano Room, Lineberger Cancer Center, from September 16, 2008 11:00 AM to September 16, 2008 12:00 PM)

John P. Richard, PhD

"The Challenges of Structural Chemical Chemogenomics" (*Pagano Room, Lineberger Cancer Center, from September 19, 2008 11:00 AM to September 19, 2008 12:00 PM)

Ruben Abagyan, PhD (*Seminar on FRIDAY)

"Integrin Associated Protein(IAP) / SHPS-1 interaction and the Cellular Response to Stress" (408 Mary Ellen Jones , from October 07, 2008 11:00 AM to October 07, 2008 12:00 PM)

David Clemmons, PhD

"Molecular Spies: reports from the front lines of multidrug and neurotransmitter transport" (*Pagano Room, Lineberger Cancer Center, from October 14, 2008 02:00 PM to October 14, 2008 03:00 PM)

Hassane Mchaourab, PhD (*Seminar at 2pm)

"Cancer Treatment By Circadian Clock Disruption" (408 Mary Ellen Jones , from October 21, 2008 11:00 AM to October 21, 2008 12:00 PM)

Aziz Sancar, PhD

"Regulation of Synaptogenesis and Neuronal Survival by the Gamma-Protocadherins" (408 Mary Ellen Jones , from October 28, 2008 11:00 AM to October 28, 2008 12:00 PM)

Joshua Weiner, PhD

"Enzyme Proficiency: Some Extreme Examples" (408 Mary Ellen Jones, from November 04, 2008 11:10 AM to November 04, 2008 12:10 PM)

Richard Wolfenden, PhD

“NF-kB signaling induced by T cell receptor and G protein-coupled receptors" (408 Mary Ellen Jones , from November 11, 2008 11:00 AM to November 11, 2008 12:00 PM)

Xin Lin, PhD

"Computational Protein Design and Drug Design" (408 Mary Ellen Jones, from November 18, 2008 11:00 AM to November 18, 2008 12:00 PM)

Bruce Donald, PhD

"Linking Oxidative Chemistry to Pathophysiology through the identification of cellular redox switches" (408 Mary Ellen Jones, from November 25, 2008 11:00 AM to November 25, 2008 12:00 PM)

Marcelo Bonini, PhD

"The Bad Apple: Poisoning HIV Assembly Identifies A New Target" (408 Mary Ellen Jones, from December 02, 2008 11:00 AM to December 02, 2008 12:00 PM)

Ronald Swanstrom, PhD

"Chromatin Remodeling Machines" (408 Mary Ellen Jones, from December 09, 2008 11:00 AM to December 09, 2008 12:00 PM)

Bradley Cairns, PhD

"Phosphatidylserine as a Second Messenger in Thrombin Production" (408 Mary Ellen Jones, from December 16, 2008 11:00 AM to December 16, 2008 12:00 PM)

Barry Lentz, PhD

"Visualizing the Structures and Conformational Changes of Biological Nanomachines with Cryo-EM" (408 Mary Ellen Jones, from December 18, 2008 03:00 PM to December 18, 2008 04:00 PM)

Phoebe Stewart, PhD (THURSDAY @ 3PM)

"Automated Microscopy in Drug Discovery and Structural Biology" (Pagano Room, Lineberger Cancer Center, from January 13, 2009 02:00 PM to January 13, 2009 03:00 PM)

JONATHAN SEXTON, PHD **TIME: 2:00 PM**

"Assembly and Destruction of Von Willebrand Factor in Human Disease" (Pagano Room, Lineberger Cancer Center, from January 20, 2009 11:00 AM to January 20, 2009 12:00 PM)

J. EVAN SADLER, MD, PHD

"DNA Replication in Cancer Cells" (1131 Bioinformatics Auditorium, from January 27, 2009 11:00 AM to January 27, 2009 12:00 PM)

ANINDYA DUTTA, MD, PHD

"Comprehensive Metabolic Profiling for Understanding Obesity and Diabetes Mechanisms" (Pagano Room, Lineberger Cancer Center, from February 03, 2009 11:00 AM to February 03, 2009 12:00 PM)

CHRISTOPHER NEWGARD, PHD

"Nuclear Targeting of an Endosomal Membrane E3 Ubiquitin" (1131 Bioinformatics Auditorium, from February 10, 2009 09:00 AM to February 10, 2009 10:00 AM)

ANN ERICKSON, PHD **TIME: 9:00 AM**

"Mechanical regulation of receptor-ligand bonds" (Pagano Room, Lineberger Cancer Center, from February 17, 2009 11:00 AM to February 17, 2009 12:00 PM)

WENDY THOMAS, PHD

"Ankyrins: Molecular Keys to Understanding How Cells Establish Specialized Membrane Domains" (1131 Bioinformatics Auditorium, from February 24, 2009 11:00 AM to February 24, 2009 12:00 PM)

VANN BENNETT, MD, PHD

"Structure and dynamics of scaffolding proteins in the assembly of membrane protein complexes" (Pagano Room, Lineberger Cancer Center, from February 25, 2009 10:00 AM to February 25, 2009 11:00 AM)

ZIMEI BU, PhD **Wednesday @ 10:00 AM** (Faculty Candidate)

"3D Super-resolution Fluorescence Microscopy" (Pagano Room, Lineberger Cancer Center, from March 03, 2009 11:00 AM to March 03, 2009 12:00 PM)

***CANCELED*** JOERG BEWERSDORF, PHD

"Docking Vesicles at the Active Zone of Ribbon and Central Synapses" (1131 Bioinformatics Auditorium, from March 10, 2009 11:00 AM to March 10, 2009 12:00 PM)

GUIDO ZAMPIGHI, PHD

"Dissecting Mechanisms of Microtubule Polymerases in Microtubule Assembly: One Tubulin Dimer at a Time" (Pagano Room, Lineberger Cancer Center, from March 12, 2009 11:00 AM to March 12, 2009 12:00 PM)

JAWDAT AL-BASSAM, PhD **Thursday @ 11:00 AM** (Faculty Candidate)

"Platelet Membranes in Blood Coagulation" (Pagano Room, Lineberger Cancer Center, from March 17, 2009 11:00 AM to March 17, 2009 12:00 PM)

BARRY LENTZ, PHD

"Role of Histone Methylation in Germ Cell Development and Obesity" (1131 Bioinformatics Auditorium, from March 24, 2009 11:00 AM to March 24, 2009 12:00 PM)

YI ZHANG, PHD

"Characterization of human epigenomes" (Pagano Room, Lineberger Cancer Center, from March 31, 2009 11:00 AM to March 31, 2009 12:00 PM)

KEJI ZHAO, PHD

"Use of insertional mutagenesis to discover novel regulators of transcription, transformation and drug resistance" (1131 Bioinformatics Auditorium, from April 07, 2009 11:00 AM to April 07, 2009 12:00 PM)

GEORGE STARK, PHD

"siRNA as a Research Tool" (Pagano Room, Lineberger Cancer Center, from April 07, 2009 04:00 PM to April 07, 2009 05:00 PM)

JIM MOORE **TIME: 4:00 PM**

"Engineering of IgG-like Monovalent, Multivalent and Bispecific Antibodies" (1131 Bioinformatics Auditorium, from April 14, 2009 09:00 AM to April 14, 2009 10:00 AM)

ALEXEY LUGOVSKOY, PHD **TIME: 9:00 AM**

"Wiring the Brain Via Eph-Ephrin Bidirectional Signaling" (1131 Bioinformatics Auditorium, from April 28, 2009 11:00 AM to April 28, 2009 12:00 PM)

MARK HENKEMEYER, PHD

Mary Ellen Jones Distinguished Women in Science Lecture (G202 MBRB, from October 27, 2009 03:00 PM to October 27, 2009 04:00 PM)

"EXTENSIVELY DRUG RESISTANT TUBERCULOSIS: SCIENTIFIC AND POLICY CHANGES"

The Fractal Self-Similarity of Protein Behavior (Pagano, Lineberger, from January 12, 2010 11:00 AM to January 12, 2010 12:00 PM)

MORGAN GIDDINGS - UNC

Structural Characterization of Cardiac Membrane Proteins Using a Hybrid of Solution and Solid-State Nuclear Magnetic Resonance Spectroscopy (1131 Bioinformatics , from January 13, 2010 01:00 PM to January 29, 2010 02:00 PM)

**Note Change: Wednesday @ 1:00 pm** NATHANIEL TRAASETH - UMN

Metabolism and Cancer (1131 Bioinformatics, from January 19, 2010 11:00 AM to January 19, 2010 12:00 PM)

YUE XIONG - UNC

Single-Event Approaches to Biological Interactions (1131 Bioinformatics, from January 25, 2010 11:00 AM to January 25, 2010 12:00 PM)

**Note Change: Monday @ 11:00 am** ELI-ROTHENBERG - UIUC

Exploiting Cool Techniques at the Mac-In-Fac for your Research (Pagano, Lineberger, from January 26, 2010 11:00 AM to January 26, 2010 12:00 PM)

ASHUTOSH TRIPATHY - UNC

An Enzyme's-Eye View of Evolution (Pagano, Lineberger, from February 02, 2010 11:00 AM to February 02, 2010 12:00 PM)

RICHARD WOLFENDEN - UNC

The Mechanism of Rhodopsin Catalyzed Nucleotide Exchange in G Proteins Revealed by Site-Directed Spin Labeling (1131 Bioinformatics, from February 03, 2010 11:00 AM to February 03, 2010 12:00 PM)

**Note Change: Wednesday @ 11:00 am** NED VAN EPS - UCLA

Taking Steps to Develop: The Dynamic Forces that Drive Tissue Morphogenesis (1131 Bioinformatics, from February 05, 2010 02:00 PM to February 05, 2010 03:00 PM)

**Note Date Change: Friday @ 2pm** ADAM MARTIN - PRINCETON

Measuring, Modeling and Manipulating Protein Interaction Specificity (Pagano, Lineberger, from February 09, 2010 11:00 AM to February 09, 2010 12:00 PM)

AMY KEATING - MIT

Study of Membrane Proteins Using Phospholipid Bilayer Nanodiscs (1131 Bioinformatics, from February 10, 2010 11:00 AM to February 10, 2010 12:00 PM)

**Note Change: Wednesday @ 11:00 am** ADITI DAS - UIUC

Molecular Switches in Integrin Adhesive Signaling (Pagano, Lineberger, from February 16, 2010 11:00 AM to February 16, 2010 12:00 PM)

JUN QIN - LRI, Cleveland Clinic

Folding Landscape from Single Molecule Force Spectroscopy (1131 Bioinformatics, from March 02, 2010 11:00 AM to March 02, 2010 12:00 PM)

DEVARAJAN (DAVE) THIRUMALAI - UMD

Simulations of Protein Folding in the Cellular Milieu (1131 Bioinformatics, from March 09, 2010 11:00 AM to March 09, 2010 12:00 PM)

JOAN-EMMA SHEA - UCSB

Characterization of the Gut Microbiome’s Role in Regulating Host Gene Expression and Metabolism in the Mammalian Colon (G202 MBRB, from March 16, 2010 11:00 AM to March 16, 2010 12:00 PM)

SCOTT BULTMAN - UNC

Dissecting Complex Biological Systems from Signaling to Epigenetic Regulation by Using Quantitative Proteomics (1131 Bioinformatics , from March 23, 2010 11:00 AM to March 23, 2010 12:00 PM)

XIAN CHEN - UNC

Prediction of Protein Structure: Tackling an Under-determined, Many Dimensional Problem (1131 Bioinformatics, from March 30, 2010 11:00 AM to March 30, 2010 12:00 PM)

DAVID SHORTLE - JOHNS HOPKINS

Stereochemical underpinnings of the genetic code for glutamine and glutamate (1131 Bioinformatics, from April 06, 2010 11:00 AM to April 06, 2010 12:00 PM)

JOHN PERONA - UCSB

FAK and PYK2 Function in Neuronal Development (G202 MBRB, from April 13, 2010 11:00 AM to April 13, 2010 12:00 PM)

***CANCELED*** HILLARY BEGGS - UCSF

Repair of chromosome breaks - unique problems, unique answers (G202 MBRB, from April 13, 2010 11:00 AM to April 13, 2010 12:00 PM)

DALE RAMSDEN - UNC

Cellular Protein S-Nitrosation Formation from Nitric Oxide: Mechanisms and Role in Signal Transduction (1131 Bioinformatics, from April 20, 2010 11:00 AM to April 20, 2010 12:00 PM)

JACK LANCASTER - UAB

Energy Landscapes Encoding Function in LDH Investigated Over Broad Time Scales (1131 Bioinformatics, from April 27, 2010 11:00 AM to April 27, 2010 12:00 PM)

BOB CALLENDER - ALBERT EINSTEIN

DNA Replication Licensing and Cell Cycle Checkpoints (1131 Bioinformatics , from May 04, 2010 11:00 AM to May 04, 2010 12:00 PM)

JEAN COOK - UNC (rescheduled from 2/23/10)

Exosite-mediated Inhibition of C/oagulation Factor IXa (G202 MBRB, from May 11, 2010 11:00 AM to May 11, 2010 12:00 PM)

JOHN SHEEHAN - MADISON

September 9 [Friday]: Gary Gilbert (Harvard Medical) (Pagano, LCCC, from September 09, 2011 11:00 AM to September 09, 2011 12:00 PM)

"Cooperative Function of the Factor VIII C1 and C2 Domains in Binding to Platelets, Apoptotic Cells, and Stressed Cells"

Seminar: Thomas Kunkel (NIEHS) (G202 MBRB, from September 13, 2011 11:00 AM to September 13, 2011 12:00 PM)

Tuesday, September 13 @ 11 AM in G202 MBRB

September 20: Peter Kasson (Univ. Virginia) (Bioinformatics 1131, from September 20, 2011 11:00 AM to September 20, 2011 12:00 PM)

"Probing the Mechanism of Influenza Membrane Fusion via Molecular Simulation"

September 27: Julia Shifman (Hebrew University) (Bioinformatics 1131, from September 27, 2011 11:00 AM to September 27, 2011 12:00 PM)

"Computational design of protein-protein interactions"

October 11: Acharan Narula (Narula Research) (G202 MBRB, from October 11, 2011 11:00 AM to October 11, 2011 12:00 PM)

"Inflammation, Immunity, and Cancer: When the 'Standard of Care' has been Exhausted, What's Next? Leads for Drug Development from Botanicals"

October 25: Mark Bedford (MD Anderson Cancer Ctr) (Bioinformatics 1131, from October 25, 2011 11:00 AM to October 25, 2011 12:00 PM)

"Identifying Methyl-Arginine Substrates and Effector Molecules"

November 1: John Cidlowski (NIEHS) (Bioinformatics 1131, from November 01, 2011 11:00 AM to November 01, 2011 12:00 PM)

"The Heart-Break of Studying Glucocortoid Receptors at NIH"

MON @ 2pm - November 7: Michael Summers (UMBC) (G202 MBRB, from November 07, 2011 02:00 PM to November 07, 2011 03:00 PM)

"Insights into mechanism of HIV-1 genome packaging and virus assembly"

November 15: Peter Chien (UMass) (Bioinformatics 1131, from November 15, 2011 11:00 AM to November 15, 2011 12:00 PM)

"Insights into protein processing from an essential AAA+ protease"

November 29: Kerry Bloom (UNC) (Bioinformatics 1131, from November 29, 2011 11:00 AM to November 29, 2011 12:00 PM)

"The Molecular Structure of a Chromatin Spring"

December 6: Jacqueline Bromberg (Sloan-Kettering) (Bioinformatics 1131, from December 06, 2011 11:00 AM to December 06, 2011 12:00 PM)

JAK/STAT Signaling in Tumorigenesis"