"Characterization of human epigenomes"

KEJI ZHAO, PHD

When Mar 31, 2009
from 11:00 AM to 12:00 PM
Where Pagano Room, Lineberger Cancer Center
Contact Name
Contact Phone 919-843-9984
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Dr. Zhao is a Principal Investigator at the Laboratory of Molecular Immunology with the National Heart Lung and Blood Institute of the NIH.  His research is focused on how the chromatin structure is modified during cellular development and how the modification determines the expression potential of a specific genomic locus using systems biology and molecular biology approaches. Dr. Zhao's lab has developed an unbiased Genome-wide MApping Technique (GMAT) to analyze global histone modifications. The method has been successfully used to identify the genome-wide target sites of the histone H3 acetylase GCN5 in yeast. Application of this technique to human T cells has allowed to us discover “histone acetylation islands” as transcriptional and chromatin regulatory elements. The 46,000 acetylation islands in T cells may represent the first experimentally identified regulatory network that mediate T cells development and differentiation. His lab is using GMAT to (1) identify patterns of histone modifications in the human genome, (2) to study how the patterns are established; (3) to reveal the relationship between histone modification patterns and gene expression profiles; and (4) to understand diseases resulting from mis-regulation of the epigenetic modifications.

To learn more, please visit his website: public.nhlbi.nih.gov/Staff/Home/UserInputForPerson.aspx.

 

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