Linda Wordeman, PhD (U Wash)

“A link between tumor suppressors, microtubule dynamics and chromosome instability"

When Sep 24, 2013
from 11:00 AM to 12:00 PM
Where Bioinformatics 1131
Contact Name
Contact Phone 919-843-9986
Attendees open to the public
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Linda Wordeman, PhD

Professor, Physiology and Biophysics
University of Washington

SEMINAR: “A link between tumor suppressors, microtubule dynamics and chromosome instability”

Host: Michael Caplow, PhD


Listen to a podcast about the seminar

Text of seminar:

Hello, welcome to the science seminar preview from the Department of  Biochemistry and Biophysics at the University of North Carolina at Chapel   Hill. My name is Hash Meriesh -- student in the Biological and Biomedical  Sciences program. And I would like to tell you about an upcoming seminar  that you will not want to miss. On Tuesday, September 24th. Dr. Linda  Wordeman - professor of physiology and biophysics at the University of  Washington will be giving a talk on “A link between tumor suppressors,  microtubule dynamics and chromosome instability”.

A distinct feature of mitosis is the alignment of chromosomes right down the  middle of the metaphase blade? The control mechanism for this process  are not well understood and deficiencies in the alignment process likely  contribute to the formation of tumors. The CEK2 protein kinase - a know  tumor suppressor - insures chromosomal stability my maintaining the  mitotic spindle assembly. While defects in the CEK2 gene are found in  nearly half of lung cancer tissues understanding how tumor suppressors  such as CEK2 influence microtubule dynamics and overall chromosomal  
stability may help us understand how tumor suppressor pathways are  transformed  leading to tumor progression and oncogene  formation.

Dr. Wordeman's groups is seeking a better understanding of the  
mechanism that control mitotic centimeter movement. While investigating  how the chromosome is maintaining the position at the metaphase blade  they found that 3 chromo-kinesins Kif18A, Kif4A and Kid all play a role in  confining centimeter movement. Kif18A activity provides the most  dominate mechanism for restricting movement by promoting microtubule  pausing while polar-ejecting forces spatially confined the chromosome.  Interesting, the pushing forces are antagonistically regulated by chromo kinesins depending on Kid for activity and antagonized by Kif4A, which  directly suppresses microtubule growth.

Please join us for Dr. Linda Wordeman's seminar, Tuesday, September  24th at 11am in Bioinformatics room 1131 for what is assured to be an exciting conversation.



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