Paul Wade, PhD (NIEHS)

“Gene regulation by chromatin”

When Nov 05, 2013
from 11:00 AM to 12:00 PM
Where Bioinformatics 1131
Contact Name
Contact Phone 919-843-9986
Attendees open to the public
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Paul A. Wade, Ph.D.

Paul Wade, PhD

Principal Investigator, Eukaryotic Transcriptional Regulation Group

Gene regulation by chromatin

Host: Greg Wang, PhD

Listen to a podcast about the seminar

Text of Podcast

Welcome to the science seminar podcast featured by the Department of Biochemistry and Biophysics at the University of North Carolina at Chapel Hill.

My name is Doan On, a 2nd year graduate student in the department.  I’d like to tell you about an upcoming seminar that you shouldn’t miss out on.

On Tuesday, November 5th, Dr. Paul Wade from the National Institutes of Environmental Health Sciences in Research Triangle Park will present his exciting research on how the NuRD complex can dictate whether our genes are turned on or off by chemically modifying the landscape of our genome.

For over 12 years, Dr. Wade has devoted his efforts to the study of the NuRD complex.  Unique at the time of its discovery, the NuRD chromatin remodeling complex was found to harbor two distinct enzymatic functions for regulating the chromatin landscape--one function as an ATP-dependent nucleosome remodeler and the other a histone deacetylase activity.

Thanks to his team’s efforts, it is now clear that NuRD complex recruitment to genes during development is critical for cell fate decisions and as well as for normal cellular functions. When these gene regulatory processes are dysregulated, Dr. Wade and colleagues have shown that the resulting global alterations in chromatin structure activate cancer-promoting transcriptional programs. This can lead to diverse cancers types ranging from aggressive metastatic breast cancers to hematopoietic malignancies.

Although it is known that the NuRD complex plays a key role in maintaining cellular identity, what remains an open area of investigation is the functional significance of NuRD complex subunits in mediating the crosstalk between chromatin chemical modifications and DNA methylation.  To tackle these questions, Dr. Wade and colleagues have developed a system to study DNA methylation patterns in cells critical for immune function called lymphocytes. 

Using this platform, his studies demonstrate that NuRD complex subunits play a key role in lymphocyte differentiation and imply that restoring normal function of these subunits could be an avenue for therapeutic intervention in lymphoid malignancies.

Please join us at Dr. Paul Wade’s seminar at 11am in room 1131 at the Bioinformatics building to learn more about his latest research into NuRD complex at the crossroads of chromatin and cancer.

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