Sep 10, 2013
from 11:00 AM to 12:00 PM
|Contact Name||Rhonda Scott|
open to public
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Associate Professor, Biochemistry and Biophysics
Member, McAllister Heart Institute
“Controlling platelet activation in health and disease: Rap GTPase signaling takes center stage ”
Host: Leslie Parise, PhD
Text for podcast.
Hello and welcome to the science seminar podcast from the Department of Biochemistry and Biophysics at the University of North Carolina - Chapel Hill. I'm Leslie Parise, professor and chair of the department and I would like to tell you about one of our upcoming seminars.
On Tuesday, September 10, Dr. Wolfgang Bergmeier, associate professor in our department will speak on "Controlling platelet activation in health and disease: Rap GTPase signaling takes center stage”. So what are platelets and why should we care? They are tiny blood cells that can become adhesive very quickly and plug up injured blood vessels thereby preventing death by bleeding. But they can also cause heart attack and strokes which kill more people in western countries more than any other cause.
That's why Dr. Bergmeier is studying signaling pathways and platelets that involve molecular switches called small GTPase and the proteins that regulate them. Rap GTPase is especially important in making platelets adhesive. Dr. Bergmeier studies the protein that switches Rap GTPase to its active state. This is called CalDAG-GEFI. Dr. Bergmeier has exciting new evidence on why CalDAG-GEFI is an excellent target for regulating platelets regulation to prevent heart attacks and strokes.
Please join us for his seminar at 11am in room G202 MBRB to learn about his latest experiments.