Hashim Al-Hashimi, PhD (Duke University)

"The Role of Nucleic Acid Dynamics in the Central Dogma of Molecular Biology"

When Oct 21, 2014
from 11:00 AM to 12:00 PM
Where Bioinformatics 1131
Contact Name
Attendees Open to the public
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Joint UNC Program in Molecular & Cellular Biophysics and UNC Biochemistry & Biophysics Seminar

"The Role of Nucleic Acid Dynamics in the Central Dogma of Molecular Biology"

Hashim Al-Hashimi

Hashim Al-Hashimi, PhD

Professor of Biochemistry and Director for the Center for RNA Biology
Duke University

Al-Hashimi Lab

Bio:  Dr. Hashim Al-Hashimi is a professor in the Department of Biochemistry with a secondary appointment as professor in the Department of Chemistry. He has assumed the role as director for the Center for RNA Biology, effective Sept. 1. He received his doctorate in Biophysical Chemistry from Yale University for research on the development of residual dipolar coupling NMR methods to study the structure and dynamics of proteins. Before joining Duke in January, he spent 11 years at the University of Michigan as assistant professor, associate professor, Robert L Kuczkowski Professor, and J. Lawrence Oncley Collegiate Professor of Chemistry and Biophysics in the Department of Chemistry and Biophysics Research Division.

Abstract:  Using NMR relaxation dispersion experiments we will show that canonical and non-canonical base pairs in DNA and RNA duplexes exist in dynamic equilibrium with alternative forms that change the chemical presentation of the genetic code. We discuss how these alternative base pairs underlie the basic mechanisms of RNA switches, DNA damage induction and repair, spontaneous mutations, sequence-specific DNA recognition and signaling.

Hosted By: Qi Zhang