SEMINAR: Leslie Parise, PhD (UNC-Chapel Hill)

CIB1 and non-oncogene addiction in cancer

When Sep 15, 2015
from 11:00 AM to 12:00 PM
Where Bioinformatics 1131
Contact Name
Attendees Open to the public
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Leslie V. Parise, PhDLeslie Parise, PhD

Professor and Chair
Department of Biophysics and Biochemistry
UNC at Chapel Hill
Parise Lab Website

"CIB1 and non-oncogene addiction in cancer"

Abstract
CIB1 is a 22 kDa intracellular regulatory protein that is required for the activation of two major oncogenic signaling pathways, RAF-MEK-ERK and PI3K-AKT, in a number of transformed cell types. CIB1 expression is also necessary for cancer cell survival and proliferation by preventing an unusual non-apoptotic cell death mediated by GAPDH translocation to the nucleus. Because the RAF-MEK-ERK and PI3K-AKT pathways are critical in a very aggressive type of breast cancer called triple negative breast cancer (TNBC), we more recently examined the role of CIB1 in TNBC cell survival and tumor growth. We find that CIB1 is critical for the survival of a majority of TNBC cell lines and supports TNBC cell growth in an in vivo xenograft model. We also identified factors predicting cell sensitivity to CIB1 depletion. Furthermore, CIB1 appears to play a role in “non-oncogene addiction”, such that certain cancer cells but not normal cells become addicted to its expression for survival, suggesting the potential of CIB1 as a therapeutic target for TNBC and other cancers.