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SEMINAR: Kun-Liang Guan (UCSD)

January 17, 2017 @ 11:00 am - 12:00 pm

Abstract: The Hippo pathway is crucial in organ size control and its dysregulation contributes to tumorigenesis. Core components of the Hippo pathway include the protein kinases of MST1/2, MAP4Ks, and LATS1/2 as well as the transcription co-activators of YAP/TAZ. MST1/2 or MAP4Ks phosphorylate and activate the Lats kinases, which then phosphorylate YAP and TAZ to promote cytoplasmic localization and degradation, thereby inactivating YAP/TAZ. The Hippo pathway is regulated by a wide range of signals, including cell density, G-protein couple receptor signaling, cytoskeletal organization, mechano signal, and cellular energy status. Uncontrolled YAP activation is frequently found in a large numbers of human cancers, particularly in uveal melanoma and malignant mesothelioma. A critical role of YAP activation in human cancers is emerging and suggests potential therapeutic value of inhibiting YAP for cancer treatment.

Kun-Liang Guan PhD, Department of Pharmacology and Moores Cancer Center, UCSD

Speaker Website http://moores.ucsd.edu/guanlab/

Details

Date:
January 17, 2017
Time:
11:00 am - 12:00 pm
Event Tags:
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