click to enlarge
Biochemistry & Biophysics alumnus, Andy Hemmert
Someday, a bio-scavenger may be a soldier’s best friend. In chemical warfare, nerve agents inhibit an enzyme that is crucial for muscle control. If the enzyme is poisoned, the diaphragm won’t move, so the victim suffocates. As a UNC doctoral student, Andy Hemmert set out to alter a similar enzyme into a bio-scavenger that would destroy all known nerve agents before they could do harm.
When Hemmert arrived at Carolina five years ago, a previous graduate student had just deciphered the structure of an enzyme in the liver that breaks down toxins. “What should we do with it?” was the question that Matt Redinbo, Ph.D., chemistry department chair, posed to the new doctoral candidate. What if, they asked, that enzyme could be changed so it would break down chemical warfare nerve agents? Hemmert went to work. “He did the work in the lab and would bring the data to me for feedback and suggestions on what to do next,” says Redinbo. “It became a really collaborative relationship.”
The U.S. military equips soldiers with treatments to neutralize some of the agents. They save lives but cause sickness and long-term side effects. Antidotes for all agents exist, but technologies to distinguish among agents – so that one knows which antidote to take – are too expensive and cumbersome to carry in the field.
Hemmert, then a biochemist based in the School of Medicine, set out to find a one-antidote-fits-all – a sort of bioscavenger. Of 560 potential changes to the enzyme, Hemmert found 50 that do the trick. Only nerve agent analogs – not the real thing – are used in UNC labs. Their lead antidote candidate will be tested at the U.S. Army Medical Research Institute of Chemical Defense. The goal is to find out if an injectable version of the antidote will have few side effects and last several days in the bloodstream. The ultimate goal? For soldiers and first responders to take the antidote before going into a situation in which they may face a chemical attack.
Meanwhile, Hemmert, Redinbo and graduate student Jonathan Edwards created a company, Identizyme Defense Technologies, to further the work. Funded by a $70,000 grant from the Army, Identizyme is renting space at UNC. Although Hemmert has since been lured away by a job offer, Redinbo and Edwards keep Identizyme thriving. Another Identizyme project could help soldiers before the catch-all antidote is ready: creating a decoder about the size of a credit card that would show color patterns depending on which nerve agents were present. A color key would tell soldiers and first responders which antidotes to take.
UNC SPOTLIGHT: http://www.unc.edu/spotlight/CCM3_020680
- Faculty News
ASBMB Today highlights Henrik Dohlman as a new JBC associate editor
Learn more about Henrik Dohlman, professor and vice chair of biochemistry and biophysics, from his profile highlight in ASBMB Today's December 2013 issue.
Sharon Campbell organizes the ASBMB Special Symposia Series to be held July 2014
Learn more about the event "Translating the Biophysics of Molecular Switches: Signaling Mechanisms and Inhibition of Ras and Rho GTPases"
New findings from the Carter lab challenge assumptions about origins of life
Dr. Charles Carter, Jr., Professor of Biochemistry and Biophysics resurrect “molecular fossils” to conduct experiments that undercut the predominant scientific theory of how life began on Earth.
Congratulations to Greg Wang, Assistant Professor of Biochemistry and Biophysics, who was awarded a Jefferson Pilot Fellowship from UNC School of Medicine to further his research mission searching for better ways to shut down cancer cells.
- Postdoc & Scholars News
2013 Retreat Winners
Scott Rothbart receives a 2013 UNC Pagano Award for a best first-author postdoctoral paper
Congratulations to Dr. Scott Rothbart, a postdoctoral fellow in Dr. Brian Strahl's lab who is one of the recipients this year of a Joseph S. Pagano award
Shobhan Gaddameedhi receives CEHS-2013 Pilot Project Award
Congratulations to Dr. Shobhan Gaddameedhi, postdoctoral fellow in Dr. Aziz Sancar's lab, received $25,000 from the Center for Environmental Health and Susceptibility 2013 Pilot Project Award.
Rothbart receives a 2013 Postdoctoral Award for Research Excellence
Congratulations to Dr. Rothbart, postdoctoral fellow in the lab of Dr. Brian Strahl, Associate Professor of Biochemistry and Biophysics, who received a 2013 Postdoctoral Award for Excellence in Research at UNC.