UNC Lineberger team finds possible strategy to overcome radiation therapy resistance acquired by cancer cells
In a new study published in the Cell Press journal "Chemistry & Biology", researchers in the Chen lab share a discovery that could lead to a new strategy for sensitizing radiation-resistant cancer cells to the treatment.
In a new pre-clinical study published today in the journal Breast Cancer Research and Treatment, researchers from the Parise lab show they can exploit cancer’s reliance on a particular protein to help fight triple negative breast cancer. They believe the protein could be a potential new drug target.
University of North Carolina researchers provide evidence for how the genetic code developed in two distinct stages to help primordial chemicals evolve into cells.
The new experimental assay can help scientists find the precise locations of repair of DNA damage caused by UV radiation and common chemotherapies. The invention could lead to better cancer drugs or improvements in the potency of existing ones.
The 18 members of the QEP steering committee, led by co-chairs Leslie Parise, professor and chair of biochemistry and biophysics, and Kevin Guskiewicz, professor of exercise and sport science and associate dean in the College of Arts and Sciences, will develop the QEP’s focus, implementation and budget before presenting a draft plan to the Provost. One of the major focuses is improvement on science learning.
The program aims to address the fundamental gaps in knowledge surrounding epigenetic regulation, with a long-term goal of developing novel therapeutic approaches towards treating human disease. Learn more about the newly launched UNC Program in Chromatin and Epigenetics!
These findings published by the Bergmeier lab in the Journal of Clinical Investigation could lead to more personalized approaches to controlling platelet activity during heart attacks and other vascular emergencies and diseases.
Brian Strahl along with other scientists at UNC have created a new way to investigate epigenetic mechanisms important in diseases ranging from Alzheimer’s to cancers. Read more about their work published in Developmental Cell.
The Department continues to rank highly for NIH funding among all Biochemistry departments in the US. In 2014, the Department secured 16.4 million in federal funding and ranks 5th.
By deleting the NrCAM gene, scientists have found a potential way to cut back on the neural connections implicated in Autism Spectrum Disorder.
Sixteen years after scientists found the genes that control the circadian clock in all cells, the lab of UNC’s Aziz Sancar, MD, PhD, discovered the mechanisms responsible for keeping the clock in sync.
Congratulations to the Strahl Lab for their recent article "Catalysis-dependent stabilization of Bre1 fine-tunes Histone H2B ubiquitylation to regulation gene transcription" that was published in the August 1, 2014 issue of Genes and Development.