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Shobhan Gaddameedhi, PhD
Each year, the UNC Postdoctoral Scholars Awards for Research Excellence are given in recognition of the research promise demonstrated by individual postdoctoral scholars. The awards are open to postdoctoral scholars in all disciplines and are designed to assist postdoctoral scholars in their continued professional development by supporting the recipients in conference travel, purchasing books, lab materials, or engaging in other scholarly activities that directly enhance the individual's professional growth. Each recipient receives a monetary award of a $1000 along with a plaque.
Dr. Gaddameedhi trains as a postdoctoral fellow in the lab of Dr. Aziz Sancar, distinguished professor of Biochemistry and Biophysics. Dr. Gaddameedhi's work thus far in the lab and for which he received the UNC Postdoctoral Award for Research Excellence has focused on the involvement of the circadian rhythm in UV-induced DNA damage signaling and skin carcinogenesis. Skin cancer is the most common form of cancer in the United States (www.skincancer.org). More than 3.5 million skin cancers in over two million people are diagnosed annually. Recently they made an important discovery that DNA repair rate exhibits daily rhythmicity in mouse skin, with a minimum in the morning and a maximum in the afternoon/evening. Therefore, we hypothesized that the mutagenicity and carcinogenicity of UVR exposure may be strongly affected by the time of day. Remarkably, they found that mice exposed to UVR in the early morning displayed an earlier onset and about a fivefold increased multiplicity of invasive squamous cell carcinoma (SCC) than mice exposed in the evening. This study has important applications in making public health recommendations to reduce skin cancer risk from occupational, therapeutic, and recreational/cosmetic exposures to sunlight or other sources of UVR.
- Faculty News
Sancar lab manuscript selected as "Paper of the Week" by JBC
The paper titled "Mechanism of Photosignaling by Drosophila Cryptochrome: Role of the Redox Status of the Flavin Chromophore" appears in the February 21, 2014 print edition of The Journal of Biological Chemistry.
Vaziri and Janzen receive NIH grant to make chemotherapy drugs more effective
A team led by Cyrus Vaziri, PhD, and William Janzen at the University of North Carolina at Chapel Hill has received a grant from the National Institutes of Health for research that could help make chemotherapy drugs more effective.
Brian Strahl featured in a video about the history of epigenetics.
Dr. Brian Strahl, associate professor of biochemistry and biophysics is featured in a video about the history of epigenetics in GEN (Genetic Engineering & Biotechnology News). The video titled, Epigenetics: A Timeline, spans 130 years of research.
Wolfgang Bergmeier earns American Heart Association award!
Wolfgang Bergmeier, PhD, will use the $400,000 award to study the role of blood platelets in inflammation and injury.
- Student News
Gauri Dixit receives her PhD!
Gauri successfully defended her dissertation and received his PhD on March 5, 2014.
Elizabeth Proctor receives a 2014 Dean's Distinguished Dissertation Award in Biological and Life Sciences
Elizabeth’s research at UNC utilized computational and experimental methods to explore the mechanism of protein aggregation in the neurodegenerative disease Amyotrophic Lateral Sclerosis.
Daul Cole receives his PhD!
Daud successfully defended his dissertation and received his PhD on December 3, 2013.
Rachel Redler receives her PhD!
Rachel successfully defended her dissertation and received her PhD on December 6, 2013.
- Postdoc & Scholars News
2013 Retreat Winners
Congratulations to Peter Thompson, Harsha Gunawarden, Seth Zimmerman, Tim Jacobs and Marino Convertino.
Scott Rothbart receives a 2013 UNC Pagano Award for a best first-author postdoctoral paper
Congratulations to Dr. Scott Rothbart, a postdoctoral fellow in Dr. Brian Strahl's lab who is one of the recipients this year of a Joseph S. Pagano award
Shobhan Gaddameedhi receives CEHS-2013 Pilot Project Award
Congratulations to Dr. Shobhan Gaddameedhi, postdoctoral fellow in Dr. Aziz Sancar's lab, received $25,000 from the Center for Environmental Health and Susceptibility 2013 Pilot Project Award.
Rothbart receives a 2013 Postdoctoral Award for Research Excellence
Congratulations to Dr. Rothbart, postdoctoral fellow in the lab of Dr. Brian Strahl, Associate Professor of Biochemistry and Biophysics, who received a 2013 Postdoctoral Award for Excellence in Research at UNC.