click to enlarge
Shobhan Gaddameedhi, PhD
Each year, the UNC Postdoctoral Scholars Awards for Research Excellence are given in recognition of the research promise demonstrated by individual postdoctoral scholars. The awards are open to postdoctoral scholars in all disciplines and are designed to assist postdoctoral scholars in their continued professional development by supporting the recipients in conference travel, purchasing books, lab materials, or engaging in other scholarly activities that directly enhance the individual's professional growth. Each recipient receives a monetary award of a $1000 along with a plaque.
Dr. Gaddameedhi trains as a postdoctoral fellow in the lab of Dr. Aziz Sancar, distinguished professor of Biochemistry and Biophysics. Dr. Gaddameedhi's work thus far in the lab and for which he received the UNC Postdoctoral Award for Research Excellence has focused on the involvement of the circadian rhythm in UV-induced DNA damage signaling and skin carcinogenesis. Skin cancer is the most common form of cancer in the United States (www.skincancer.org). More than 3.5 million skin cancers in over two million people are diagnosed annually. Recently they made an important discovery that DNA repair rate exhibits daily rhythmicity in mouse skin, with a minimum in the morning and a maximum in the afternoon/evening. Therefore, we hypothesized that the mutagenicity and carcinogenicity of UVR exposure may be strongly affected by the time of day. Remarkably, they found that mice exposed to UVR in the early morning displayed an earlier onset and about a fivefold increased multiplicity of invasive squamous cell carcinoma (SCC) than mice exposed in the evening. This study has important applications in making public health recommendations to reduce skin cancer risk from occupational, therapeutic, and recreational/cosmetic exposures to sunlight or other sources of UVR.
- Faculty News
ASBMB Today highlights Henrik Dohlman as a new JBC associate editor
Learn more about Henrik Dohlman, professor and vice chair of biochemistry and biophysics, from his profile highlight in ASBMB Today's December 2013 issue.
Sharon Campbell organizes the ASBMB Special Symposia Series to be held July 2014
Learn more about the event "Translating the Biophysics of Molecular Switches: Signaling Mechanisms and Inhibition of Ras and Rho GTPases"
New findings from the Carter lab challenge assumptions about origins of life
Dr. Charles Carter, Jr., Professor of Biochemistry and Biophysics resurrect “molecular fossils” to conduct experiments that undercut the predominant scientific theory of how life began on Earth.
Congratulations to Greg Wang, Assistant Professor of Biochemistry and Biophysics, who was awarded a Jefferson Pilot Fellowship from UNC School of Medicine to further his research mission searching for better ways to shut down cancer cells.
- Postdoc & Scholars News
2013 Retreat Winners
Scott Rothbart receives a 2013 UNC Pagano Award for a best first-author postdoctoral paper
Congratulations to Dr. Scott Rothbart, a postdoctoral fellow in Dr. Brian Strahl's lab who is one of the recipients this year of a Joseph S. Pagano award
Shobhan Gaddameedhi receives CEHS-2013 Pilot Project Award
Congratulations to Dr. Shobhan Gaddameedhi, postdoctoral fellow in Dr. Aziz Sancar's lab, received $25,000 from the Center for Environmental Health and Susceptibility 2013 Pilot Project Award.
Rothbart receives a 2013 Postdoctoral Award for Research Excellence
Congratulations to Dr. Rothbart, postdoctoral fellow in the lab of Dr. Brian Strahl, Associate Professor of Biochemistry and Biophysics, who received a 2013 Postdoctoral Award for Excellence in Research at UNC.