Each module investigates principles and mechanisms of signal transduction and cell proliferation control with an emphasis on in-depth discussion of current literature and unanswered questions in the field.  Modules are team-taught with major themes selected by the instructors each year.  Themes include protein kinases, GTPases, cell cycle control, signaling specificity and feedback (networks), tumor suppressors and oncogenes, signaling in development and stem cell biology etc.  Enrollment is by permission of each module leader.  

Themes and module leaders for Spring 2018

BIOC 745 - Intercellular Signaling in Development & Disease.

(1 Credit)
(5 weeks Module) Jan 9*-Feb 8)
T/TH 2 PM-3:30 PM
4095 Genetic Medicine Bldg
Course director: Dr. Yuliya Pylayeva-Gupta, Student services managerLisa Phillippie, ldh@med.unc.edu

Course Outline 

This graduate-level course concentrates on up-to-date views of intercellular signal processing, with emphasis on signal transduction mechanisms as they relate to cellular/physiological responses in both normal development and disease. Signaling mechanisms that will be discussed include paracrine, juxtacrine signaling and cell-matrix interactions. Model systems will include examples from neurobiology, gastrointestinal biology, cardiovascular system and immune system. The role of intercellular signaling and its targeting in cancer will be discussed. The course format will combine lectures and in-class discussion of assigned readings, with particular emphasis on state-of-the art research methods to study cell signaling between cells. In addition to materials focused on recent advances, hallmark historical papers will be discussed. Students are expected to have prior knowledge of genetics, cell biology and molecular biology.  Be advised this course does start on January 9.    

BIOC 744 - Stem Cell Biology and Regenerative Medicine

(2 credit)
(10 weeks module) Feb 13-April 24
T/TH 9:30 AM-10:45 AM
Location: 3007 GMB
Course director: Stephen Crews, steve_crews@unc.edu
Student services managerLisa Phillippie, ldh@med.unc.edu
Course Outline 

This graduate-level course addresses key issues in stem cell biology and regenerative medicine while providing insights into important aspects of developmental biology, stem cell technology, and human disease. Experimental systems to be studied include human stem cells as well as the mouse, zebrafish, and Drosophila model systems. Cell types to be explored include iPS and ES cells, the nervous system, epidermis, intestine, and cardiovascular system. The role of stem cells in human oncogenesis and their therapeutic use in human disease will be discussed. The class format combines lectures and in-class discussion of assigned readings selected from both seminal works and recent articles. Students are expected to have taken courses in genetics, cell biology, and molecular biology or to have acquired knowledge in those fields.