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ELIZABETH CLAIRE DEES, MD Assistant Professor Department of Hematology-Oncology CB #7305, 3009 Old Clinic Building Chapel Hill, NC 27599-7305 Phone: (919) 843-7714 Fax: (919) 966-6735 E-Mail: Claire_Dees@med.unc.edu |
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TABLE OF CONTENTS:
RESEARCH INTERESTS:
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My research objectives are to design and conduct early phase clinical trials that evaluate
novel compounds and new combinations of drugs to treat breast cancer. I am interested in
evaluating the pharmacologic and pharmacogenetic determinants of interpatient variability
in toxicity of chemotherapy. I am particularly interested in developing new chemotherapy
regimens that may be more appropriate for older women with breast cancer, and further
investigating the causes of age-related differences in toxicity and efficacy. This work
will require interdisciplinary collaborations with basic scientists, pharmacologists,
pharmacokineticists, and geriatricians, in addition to the collaborations with surgeons,
radiation oncologists, radiologists, geneticists, and others with are part of the daily
clinical care of breast cancer patients.
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FUNDING:
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Private Funder: Doris Duke Clinical Scientist Development Award Title of Project: P450 Phenotype and Chemotherapy Toxicity in the Elderly Month Awarded: June, 2001 |
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BIRCWH MENTOR:
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Paul Watkins, MD Division Chief, Hematology/Oncology UNC, Department of Medicine 3009 Old Clinic Bldg., CB#7305 Chapel Hill, NC (919) 966-4431 |
EDUCATION:
| Bachelor of Science: |
Princeton University Princeton, NJ |
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| Doctor of Medicine: |
Duke University Durham, NC |
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| Internship & Residency: |
Brigham and Women's Hospital Boston, MA
Johns Hopkins Oncology Center |
1993-1996 1996-1999 |
| M.Sc. in Clinical Investigation: |
Johns Hopkins University School of Hygiene and Public Health Baltimore, MD (expected, pending thesis submission) |
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| Fellowship: |
John Hopkins Oncology Center Baltimore, MD |
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| Board Certifications: |
American Board of Internal Medicine American Board of Internal Medicine (Oncology) |
CURRENT PUBLICATIONS:
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Dees EC, Rowinsky EK, Noe DA, O'Reilly S, Adjei A, Elza-Brown K and Donehower RC. "A Phase I and pharmacologic study of pyrazoloacridine and cisplatin in patients with advanced cancer." (manuscript submitted for publication). Dees EC, O'Reilly S, Goodman S, Sartorius S, Levine MA, Jones RJ, Grochow LB, Donehower RC and Fetting JH. "A prospective pharmacologic evaluation of age-related toxicity of adjuvant chemotherapy in women with breast cancer." Cancer Investigation, 18(6):521-29 (2000). Dees EC, Whitfield LR, Grove WR, Rummel S, Grochow LB and Donehower RC. "A Phase I and pharmacologic evaluation of the DNA Intecalator CI-958 in patients with advanced solid advanced cancer." (manuscript submitted for publication). Dees EC, Shulman L.N., Souba WW and Smith BL. "Does information from axillary dissection change treatment in clinically node-negative patients with breast cancer? An algorithm for assessment of the impact of axillary dissection." Annals of Surgery 226(3):279-87 (1997). Brannan CI, Dees EC, Ingram RS and Tilghman SM. "The product of the H19 gene may function as an RNA." Mol, Cell. Biol., 10:28-36 (1990). |