BIRCWH - Scholar, Susan S. Smyth, MD, PhD  

BIRCWH Associate 2002-2003

 
SUSAN S. SMYTH, MD, PhD 
Assistant Professor 
Department of Medicine
Division of Cardiology
CB #7126, UNC-Chapel Hill 
Chapel Hill, NC 27599-7126
Phone:  (919) 843-4583
Fax:  (919) 843-4585
E-Mail:   ssmyth@med.unc.edu


TABLE OF CONTENTS:

 


  RESEARCH INTERESTS:

  The broad goal of my research is to study the molecular basis of vascular disease and then, through creative and innovative approaches, apply that knowledge to improve the diagnosis and therapy of cardiovascular disorders. Arterial amage, such as that which occurs after the rupture of an atherosclerotic plaque or following percutaneous coronary interventions, triggers a stereotypic response that begins with platelet deposition and leukocyte recruitment. Acutely, the damage may elicit the formation of an occlusive platelet-rich thrombus or, over time, may stimpulate smooth muscle cell proliferation, migration, matrix deposition, and the development of intimal hyperplasia. The focus of my work is on cell adhesion molecules that mediate interations between platelets, leukocytes, and the vessel wall. A main approach of my laboratory is to develop and exploit mouse models of cardiovascular disease in which genetic and pharmacologic strategies can be used to identify and define roles for specific molecules in vascular (patho)physiology. My work also has broad implications for treatment and prevention of tumor angiogenesis, osteoporosis, and other disorders that are mediated by specific adhesion molecules.

 
FUNDING:

 
NIH Institute:   National Heart, Lung & Blood Institute
Title of Project:   Platelet Membrane Proteins in Thrombosis
Month Awarded:   July, 2001
Type of Award:   K08 		 
Organization:   American Society of Hematology
Title of Project:   P-Selectin in Platelet-Platelet Interactions
Month Awarded:   July, 2001
Type of Award:   Junior Faculty Scholar Award

 
BIRCWH MENTOR:

  Cam Patterson, MD
Associate Professor of Medicine
Director, Carolina Cardiovascular Biology Center
UNC, Department of Medicine, Division of Cardiology
5109 Neuroscience Research Building, CB#7126
Chapel Hill, NC 27599-7126
(919) 843-4591

 
EDUCATION:

Bachelor of Arts: Mount Holyoke College
Biological Sciences, summa cum laude
 
1987
Doctor of Philosophy: University of North Carolina at Chapel Hill
Pharmacology
 
1992
Doctor of Medicine: University of North Carolina at Chapel Hill
1994
Residency: The State University of New York at Stony Brook
Internal Medicine 
1994-1997
 
  Chief Resident, Internal Medicine The State University of New York at Stony Brook
Internal Medicine 
1997
 
Fellowship: Mount Sinai Medical Center
Medicine/Cardiology 
1998-2001
 

 
CURRENT PUBLICATIONS:


Last Updated: 10/13/02

Palmerini T, Nedelmas M, Scudder L, Nakada M, Jordan R, Smyth SS, Gulle V, Gordon R, Fallon J, Krueger L, Michelson A and Coller B. "Effects of abiciximab on the acute pathology of blood vessels after arterial stenting in nonhuman primates." J. American College of Cardiology, in press (2002).

Smyth SS, Pathak A, and Stouffer GA. "In-stent restenosis. More light on a difficult problem." American Heart Journal, in press (2002).

Morris AJ, Wang Z, Sciorra V and Smyth SS. "Phosphatidic acid phosphatase 2A regulates lysophospholipid signaling in human platelets." Blood 98:3278 (2001).

Evangelista V, Manarini S, Cerletti C, Coller BS and Smyth SS. "Role of P-selectin, Alpha-Mß2, and Src tyrosine kinase in mouse PMN-platelet interactions." Thrombosis and Haemostasis, Supplement 86:2002.

Smyth SS, Reis ED, Yu H and Coller BS. "Antibody inhibition of Alpha-V and ß3 integrins but not inherited integrin-deficiency protects mice from developing intimal hyperplasia after vascular injury." Thrombosis and Haemostasis, Supplement 86:2788 (2001).

Jirouskova M, Smyth SS and Coller BS. "A hamster monoclonal antibody to the C-terminus of the mouse fibrinogen chain inhibits platelet-fibrinogen interactions and factor XIIIa-mediated fibrin crosslinking, and facilitates thrombolysis." Thrombosis and Haemostasis, 86:1047-56 (2001).

Zhang ZG, Zhang L, Wayne T, Goussev A, Powers C, Ho K, Morris D, Smyth SS, Coller BS and Chopp M. "Dynamic platelet accumulation at the site of the occluded middle cerebral artery and in downstream microvessels is associated with loss of microvascular integrity after embolic middle cerebral artery occlusion." Brain Research, 912:181-94 (2001).

Smyth SS, Reis ED, Vaananen H, Zhang W, Scudder LE and Coller BS. "Variable protection of ß3-integrin-deficient mice from thrombosis initiated by different mechanisms." Blood, 98:1055-1062 (2001).

Smyth SS, Reis ED, Zhang W, Fallon JT, Gordon RE and Coller BS. "ß3-integrin-deficient mice, but not P-selectin-deficient mice, develop intimal hyperplasia after vascular injury: correlation with leukocyte recruitment to adheraent platelets one hour post injury." Blood, 98:1055-1062 (2001).

Reis ED, Smyth SS, and Coller BS. "‘Mouse Model of Transluminal Femoral Artery Injury’ in Vascular Disease and Injury: Preclinical Research. D. Simon & C. Rogers, eds." Humana Press, pp 103-13 (2000).

Parise LV, Smyth SS, and Coller BS. "‘Platelet morphology, biochemisty, and function’ in William's Hematology, 6th Edicition, Beutler, E. Lichtman, MA, Coller BS, Kipps TJ, Seligsohn U, eds." McGraw-Hill, Inc., New York, pp 1357-1408 (2000).

Smyth SS, Tsakiris DA, Scudder LE and Coller BS. "Structure and function of murine Alpha-llbß3 (GPIIb/IIIa): studies using monoclonal antibodies and ß3-null mice." Thrombosis and Haemostasis, 84:1103-8 (2000).

Lengweiler S, Smyth SS, Jirouskova M, Scudder LE, Moran T and Coller BS. "Preparation of monoclonal antibodies to murine platelet glycoprotein IIb/IIIa (Alpha-IIbß3) and other platelet proteins from hamster-mouse interspecies hybridomas." Biochemical and Biophysical Research Communications, 262:167-173 (1999).

Smyth SS and Fassease P. "Treating prosthetic heart valve thrombosis with thrombolytics." Cardiology Review, 15:1415-1417 (1998).

Peerschke EIB, Smyth SS, Teng EI, Dalzell M and Ghebrehiwet B. "Human umbilical vein endothelial cells possess binding sites for the globular domain of C1q." J. Immunology, 157:4154-4158 (1996).

Smyth SS, Joneckis CJ and Parise LV. "Regulation of vascular integrins." Blood, 81:2827-2843 (1993).

Smyth SS, Hillery CA and Parise LV. "Regulation of ligand binding to glycoprotein IIb-IIIa (integrin Alpha-IIbß3) in isolated platelet membranes." Biochemical Journal, 292:749-758 (1993).

Smyth SS, Hillery, CA and Parise LV. "Fibrinogen binding to platelet glycoprotein IIb-IIIa s modulated by lipids." Journal of Biological Chemistry 267:22368-22375 (1992).

Hillery C, Smyth SS and Parise LV. "Phosphorylation of human platelet glycoprotein IIIa (GPIIIa): dissociation from bibrinogen binding and phosphorylation of GPIIIa in vitro." Journal of Biological Chemistry 266:14663-14669 (1991).