BIRCWH - Scholar, Joan Taylor, PhD

TABLE OF CONTENTS:

RESEARCH INTERESTS:

The overall goal of this project is to characterize the integrin signaling pathways that play a role in growth and development of the heart. I have previously demonstrated that cell-matrix interactions regulate the ability of cultured cardiomyocytes to respond to a variety of hypertrophy-inducing agents and that these pathways are dependent on the activation of the protein tyrosine kinase, focal adhesion kinase. The aims of this proposal are twofold: first, to biochemically characterize the components of the integrin-signaling cascade required for cardiomyocyte hypertrophy and second, to develop mouse models using Cre/Lox technology to study the role of focal adhesion kinase and key downstream regulatory factors in cardiac development and hypertrophy in vivo.

BIRCWH MENTOR:

Frank C. Church, MD
Professor of Pathology and Laboratory Medicine
UNC
942 M.E. Jones Bldg., CB#7035
Chapel Hill, NC
(919) 966-3311

EDUCATION:

Bachelor of Science:	University of Michigan, Ann Arbor, MI Biology	1988
PhD:	University of Michigan, Ann Arbor, MI Pharmacology	1991-1995
Post-doc:	University of Virginia, Charlottesville, VA Microbiology	1995-1999
Professional Training:	Assistant Professor, Dept. Pathology and Lab Medicine University of North Carolina Assistant Professor of Research, Dept. of Microbiology University of Virginia Post-Doctoral Fellow, Dept. of Microbiology University of Virginia Graduate Student Research Assistant, Dept. of Pharmacology University of Michigan Research Assistant, Dept. of Pharmacology University of Michigan Laboratory Assistant, Dept. of Pharmacology University of Michigan	2001-present 1999-2001 1995-1999 1991-1995 1988-1991 1985-1988

PROFESSIONAL ORGANIZATIONS:

Member, Sigma Xi Scientific Honor Society

CURRENT PUBLICATIONS:

Last Updated: 10/14/02
Taylor JM, Mack CP, Nolan K, Regan CP, Owens GK, and Parsons JT. "Selective Expression of an Endogenous Inhibitor of FAK Regulates Proliferation and Migration of Vascular Smooth Muscle Cells." Mol. Cell Bio1, 21(5):1565-1572 (2001). Taylor JM, Rovin JD, Parsons JT. "A role for Focal Adhesion Kinase in phenylephrine-induced hypertrophy of rat ventribular cardiomyocytes." J. Biol. Chem, 275(2):19250-19257 (2000). Parsons JT, Martin KH, Slack JK, Taylor JM, and Weed SA. "Focal Adhesion Kinase: a regulator of focal adhesion dynamics and cell movement." Oncognene, 19:5605-5613 (2000). Taylor JM, Macklem MM, and Parsons JT. "Cytoskeletal changes induced by Graf, the GTPase regulator associated with Focal Adhesion Kinase are mediated by down-regulation of Rho." J. Cell Science, 112(2):231-242 (1999). Taylor JM, Hildebrand JD, Mack CP, Cox ME, and Parsons JT. "Characterization of Graf, the GTPase-activating protein for Rho associated with Focal Adhesion Kinase. Phosphorylation and possible regulation by mitogen-activated protein kinase." J. Biol. Chem., 273(14):8063-8070 (1998). Sheffield, PJ, Derewenda U, Taylor JM, Parsons JT, and Derewenda ZS. "Expression, purification and crystallization of a BH-domain from the GTPase regulatory protein associated with focal adhesion kinase." Acta Crystal, D55:356-359 (1998). Taylor JM, Richardson A, and Parsons JT. "Modular domains of focal adhesion-associated proteins." Current Topics in Microbiology and Immunology, 228:135-163 ed. Pawson AJ (1998). Hidebrand JD, Taylor JM, and Parsons JT. "An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase." Mol. Cell Bio., 16(6):3169 (1996). Wade SM, Scribner MK, Dalman HM, Taylor JM, and Neubig RR. "Structural requirements for Go activation by receptor-derived peptides: activation and modulation domains of the a2 adrenergic receptor i3c region." Mol. Pharm., 50(2):351-8 (1996). Taylor JM, Jacob-Mosier GG, Lawton RG, VanDort M, and Neubig RR. "Receptor and Membrane Interaction Sites on Gb. A receptor-derived peptide binds to the carboxy-terminus." J. Biol. Chem, 27(7):3336 (1996).