Mar 11, 2013
from 02:00 PM to 03:00 PM
|Where||Med Research Bldg D, Conference room|
|Contact Name||Ann Sherman|
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Please join us for this very exciting BRIC Seminar Series!
Presented by Xiaopeng Zong, Ph.D.
Research Associate, University of Pittsburgh, NeuroImaging Laboratory
"Chemical Exchange Sensitive MRI: Amide and Amine Protons"
Monday, March 11th, 2013 2:00-3:00 PM
Medical Research Building D Conference Room
Imaging the pH and chemical compositions of the brain is important for understanding brain function and may provide useful information in clinical applications of brain diseases. Chemical exchange of protons between water and biomolecules can be exploited in magnetic resonance imaging (MRI) for measuring pH and metabolite/protein concentration changes which are detected indirectly through water signal with enhanced sensitivity by applying saturation or spin-locking radiofrequency pulses. Exchangeable amide and amine protons are abundant in the brain and have been shown to be promising chemical exchange sites in preclinical studies of brain cancer and stroke. In this talk, I will present the physical principles and the quantification and optimization issues of chemical-exchange sensitive MRI and discuss the in vivo signal source of MRI techniques sensitive to the amide- and amine–water proton exchange.