Nov 13, 2012
from 03:05 PM to 04:00 PM
|Contact Name||Ann Sherman|
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Please join us for our next Seminar Series presentation, by Laurent Younes, Ph.D., from the Department of Applied Mathematics and Statistics, Center for Imaging Science, Johns Hopkins University!
Dr. Younes will be presenting "Analysis of Shape Datasets in the Brain and in the Heart."
Abstract: We describe a processing pipeline for the analysis of large datasets of triangulated surfaces, arising from brain or cardiac medical images. Starting from segmented regions of interest (such as brain subvolumes, or cardiac ventricles), the pipeline executes the following sequence of operations: computation of a population average, or template, registration of all shapes on the template using large deformation diffeomorphic metric mapping algorithm (LDDMM) and statistical analyses of group differences based on deformation markers. The approach is illustrated by specific examples, involving Alzheimer's disease (BIOCARD, ADNI), Huntington disease (PREDICT) and hypertrophic cardiomyopathy.