P: 304 B Davie Hall, CB 3271 | F: 919.962.2537
Addiction, Executive Function, fMRI
My research focuses on investigating the neurobiology of cognitive intermediate phenotypes for addictive disorders. I am particularly interested in understanding perturbations to three aspects of the perception – action cycle: attentional bias toward addiction-related stimuli, stimulus-response association learning, and immediate reward selection bias. Integral to this work is understanding the therapeutic action of existing treatments and identifying new targets and strategies for preventing and treating addictive disorders. Our lab uses cognitive testing, neuroimaging, behavioral pharmacology, genetic, epigenetic, and hormone analysis methods in human subjects.
Boettiger CA, Mitchell JM, Tavares VC, D’Esposito M, Fields HL. (2007) Immediate reward bias in humans: fronto-parietal networks and a role for the catechol-O-methyltransferase 158(Val/Val) genotype. Journal of Neuroscience 27:14383-14391.
Boettiger CA, Kelley, EA, Mitchell JM, D’Esposito M, Fields HL. (2009) Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network. Pharmacology Biochemistry and Behavior 93:291-299. PMCID: PMC2729462
Crews FT, Boettiger CA. (2009) Impulsivity, Frontal Lobes and Risk for Addiction. Pharmacology Biochemistry and Behavior 93:237-247. PMCID: PMC2730661
Chanon VW, Sours CR, Boettiger CA (2010) Attentional bias toward cigarette cues in active smokers. Psychopharmacology, 212:309-320. PMCID: PMC2967198
Altamirano LJ, Fields HL, D’Esposito M, Boettiger CA (2011) Interaction Between Family History of Alcoholism and Locus of Control in the Opioid Regulation of Impulsive Responding under the Influence of Alcohol. Alcoholism Clin Exp Res. 35:1905-1914. PMCID: PMC3158828.
Garland E, Howard M, Boettiger CA (2011) Targeting Cognitive-Affective Risk Mechanisms in Stress-Precipitated Alcohol Misuse, Dependence, and Relapse: An Integrated, Biopsychosocial Model of Allostasis, Automaticity, and Addiction. Medical Hypotheses 76:745-54. PMCID: PMC3076531.
Smith CS, Boettiger CA (2012) Age modulates the effect of COMT genotype on delay discounting behavior. Psychopharmacology 222:609-617. PMCID:PMC3401276.
Garland E, Boettiger CA, Gaylord S, Chanon VW Howard M (2012) Mindfulness is Inversely Associated with Alcohol Attentional Bias Among Recovering Alcohol-Dependent Adults. Cognitive Ther Res 36:441-450. PMCID:PMC3532517.