Basic Science Research Laboratory - Burnett Womack Building
- Haitao Wen, PhD, Principal Investigator
About the Lab
The Wen laboratory studies the innate immunity and inflammatory-associated diseases. By employing various approaches including gene deletion, biochemical, proteomics, and animal models we aim to study the mechanisms by which immune receptors regulate inflammation and cell stress responses, and their applications in inflammation-associated diseases. Two major research directions are listed below:
- Nrf2 regulation of cell stress response in polymicrobial sepsis. Nrf2 is an essential transfection factor that mediates cellular antioxidant responses by regulating the expression of various phase II detoxifying enzymes and antioxidants. Recently we identified a novel function of Nrf2 in promoting inflammasome activation, which plays an important role for macrophage bactericidal effect. Using cecal ligation and puncture (CLP) animal model, we are currently investigating the function of Nrf2-inflammasome signaling is polymicrobial sepsis.
- Mitochondrial metabolism on immune signaling. The mitochondrion plays an essential role in the host innate immune response against invading pathogens. Mitochondria regulate immune signaling by providing ideal platform for the assembly of multiple innate signaling complexes and intermediate metabolites. One critical factor for mitochondrial metabolism is Ca2+ signaling-mediated metabolism in immune response and cell stress response.