Ongoing Clinical Trials

The following are current clinical trials being conducted by the Burn Clinical Research Group:

Effect of Burn Size on Cytomegalovirus Reactivation and Correlates of T Cell Immune Function in Burned Patients

Purpose: The purpose of this study is to evaluate the effect of burn injury on the human immune system with a focus on cytomegalovirus (CMV) reactivation and the immunologic correlates of latent viral reactivation.

ClinicalTrials.gov ID: NCT00467532

 Sponsor: UNC-Chapel Hill Status: Active, Not Recruiting

 

Prospective evaluation of the effects of topical therapy with SulfamylonR for 5% topical solution on Autograft Healing in subjects with thermal injuries requiring Meshed Autografts: A comparison to a historical control group

Purpose: The primary objective is to compare the effectiveness of treatment with Sulfamylon® solution as the initial topical moist dressing over meshed autografts following the initial graft procedure on preventing graft loss in a prospective cohort of subjects versus a historical control group in a non-inferiority trial.

ClinicalTrials.gov ID: NCT00634166

 

Sponsor:

Mylan Bertek Pharmaceuticals

Status: Active, Not Recruiting

 

 

A Multicenter Comparative Study of the ReCell Device and Autologous Split-Thickness Meshed Skin Graft in The Treatment of Acute Burn Injuries

Purpose: This is a randomized, within-patient controlled study to compare the clinical performance of the ReCell Device with that of Split-thickness Meshed Skin Grafts for the treatment of second degree burns. The hypothesis to be supported are: 1) non-inferiority with the primary efficacy endpoint defined as recipient site wound closure at week 4 follow-up visit of the ReCell-treated area as compared to that of the STMSG-treated area, and 2)superiority in the healing of the ReCell donor site as compared to the STMSG donor site at week 1.

ClinicalTrials.gov ID: NCT01138917

 Sponsor: UNC-Chapel Hill Status: Active, Recruiting

 

A Trial of Restrictive Versus Traditional Blood Transfusion Practices in Burn Patients

Purpose: The purpose of this study is to find out if burn injured patients do better receiving fewer blood transfusions than what is traditionally given. We traditionally provide blood transfusions to maintain a hemoglobin level, which is an indicator of the level of red blood cells that carry oxygen in your body, to above 10 g/dl (g/dl stands for grams per deciliter and is the standard measurement used to indicate the level of red blood cells in your blood). However, a preliminary study indicated that maintaining the hemoglobin level to above 7-8 g/dl with less blood transfusion, as compared to a hemoglobin level of 10 g/dl and above, would reduce the occurrence of blood infection, duration on the respirator and length of hospital stay, yet would achieve similar survival in both groups.

ClinicalTrials.gov ID: NCT01079247

 Sponsor: UNC-Chapel Hill Status: Active, Recruiting

 

The Relationship of Rehabilitation Therapy Time to the Prevention of Burn Scar Contracture (ACT)

Purpose: This project will develop a descriptive database of patient information and patient outcomes. This database will be used to determine the association of time spent in rehabilitation and patient outcomes, to relate patient acuity to burn scar contracture development and to establish minimal time requirement guidelines for various rehabilitation patient outcomes.

ClinicalTrials.gov ID: NCT01161810

 Sponsor: UNC-Chapel Hill Status: Active, Recruiting