Welcome to the ACTION UNC Molecular Reference Laboratory!

The Alliance for Clinical Trials in Oncology (ACTION) Molecular Reference Laboratory at the University of North Carolina provides a range of molecular assays for use in clinical trials.

Genomic technologies include:

1. DNA sequencing (MiSeq, HiSeq, Ion Torrent PGM, Sanger, or pyrosequencing).

2. RNAseq, mRNA & microRNA profiles on Agilent, Affymetrix, Nanostring, Exiqon, or Roche systems.

3. Gene copy number variation (loss, gain, loss of heterozygosity, selected rearrangments) on DNA using Agilent, Affymetrix 6.0 or SNP chip, Nanostring, or Roche LC480 platforms.

Specimen Requirements:

Formalin-fixed paraffin-embedded tissue, fresh tissue stabilized upon collection (e.g. freeze at -800C, immerse in RNALater), blood, marrow, fine needle aspirate, or DNA/RNA from pathologist-vetted specimens.

CLIA-certified, clinical-grade testing:

Many assays can be provided in an analytically validated form, thus permitting consented patients to be managed based on test results (e.g. qualify for enrollment, assign study arm, select dose).