UNC Chapel Hill School of Medicine
The Carolin Center for Clinical Trials

Current Studies

The Division of Cardiology:

  • Kirkwood Adams, MD
    • A Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Darbopoetin Alfa Treatment on Mortality and Morbidity in Heart Failure Subjects with Symptomatic Left Ventricular Systolic Dysfunction and Anemia
    • A Longitudinal Study of Beta-Blocker Utilization in Patients with Heart Failure
    • A Multicenter, Randomized, Double-Blind, Placebo-controlled, study of the effects of KW-3902 Injectable Emulsion on Heart Failure Signs and Symptoms and Renal Function in Subjects with Acute Heart Failure Syndrome and Renal Impairment who are Hospitalized for Volume Overload and Require Intravenous Diuretic Therapy

    • A Multicenter, Automatic Defibrillator Implantation Trial with Cardia Resynchronization Therapy (MADIT-CRT)
    • Double-Blind, Placebo-Controlled, Multicenter Acute Study of the Clinical Effectiveness of Nesiritide in Subjects with Decompensated Heart Failure
  • Mauricio G. Cohen, MD
    • A Phase 2 Study of the Prevention of Acute Ischemic Safety Events In Patients with a Recent Acute Coronary Syndrome
    • Effect of the Omega n3 Fatty Acids (OMACOR, Reliant Pharmaceutical) on Human Platelet Function
    • A Randomized, Multi-Center, Open-Label, Parallel Group Feasibility Study to Determine the Safety and Efficacy of the Rationally Engineered Heparin M118 vs. Unfractionated Heparin in Subjects with Stable Coronary Artery Disease Undergoing Percutaneous Coronary Intervention (EMINENCE)
    • A Randomized, Double-Blind, Parallel Group, Phase 3, Efficacy and Safety Study of AZD6140 Compared with Clopidogrel for Prevention of Vascular Events in Patients with Non-St Elevation Acute Coronary Syndromes - PLATO
  • George Stouffer , MD
    • A Phase 2a, Single-Center, Open Label, Randomized, Feasibility and Safety Study Comparing the REG1 Anticoagulation System with Unfractionated Heparin in Subjects with Coronary Artery Disease who are Undergoing Elective Percutaneous Coronary Intervention After Treatment with Clopidogrel and Aspirin (Regado 2)