Faber Lab - Publications

Selected Publications

Al-Ali F, Elias JJ, Filipkowski DE, Faber JE (2015) Acute ischemic stroke treatment, part 1:  Patient Selection.  “The 50% barrier and the capillary index score.” Frontiers in Neurology 22 April 2015, doi: 10.3389/fneur.2015.00083.

Moore SM, Zhang H, Maeda N, Doerschuk, Faber JE (2015) Cardiovascular risk factors cause premature rarefaction of the collateral circulation and greater ischemic tissue injury.  Angiogenesis April 11 on-line.

Prabhakar P, Zhang H, Chen D, Faber JE (2014) Genetic variation in retinal vascular patterning predicts variation in pial collateral extent and infarct volume after middle cerebral artery occlusion.  Angiogenesis. 2014 Nov 5, DOI 10.1007/s10456-014-9449-y. Journal cover article

Faber JE, Chilian WM, Deindl E, van Royen N, Simons M. A brief etymology of the collateral circulation. Arterioscler Thromb Vasc Biol. 2014;34:1854-9.  http://atvb.ahajournals.org/content/34/9/1854.full.pdf+html

Sealock R, Zhang, Lucitti JL, Moore SM, Faber JE (2014) Congenic fine-mapping identifies a major causal locus for variation in the native collateral circulation and ischemic injury in brain and lower extremity.  Circ Res.114:660-71. http://circres.ahajournals.org/content/114/4/660.full.pdf+html   Journal cover and highlighted article.  Featured in editorial:  Collateral development – The quest continues. Lohr NL, Circ Res.114:591-3. http://circres.ahajournals.org/content/114/4/591.full.pdf+html

Bastiaansen AJ, Ewing MM, Hetty, de Boer HC, van der Pouw Kraan TC, de Vries MR, Peters HA, Arens R, Moore SM, Faber JE, Jukema JW, Hamming JF, Nossent AY, Quax PH (2013) The lysine acetyltransferase PCAF is a key factor in controlling arteriogenesis. Arterioscler Thromb Vasc Biol. 2013;33:1902-10. http://atvb.ahajournals.org/content/33/8/1902.full.pdf+html Journal cover article.

Menon BK, Smith EE, Coutts SB, Welsh DG, Faber JE, Goyal M, Hill MD, Demchuk AM, Damani Z, Cho KH, Chang HW, Hong JH, Sohn SI (2013) Leptomeningeal collaterals are associated with modifiable metabolic risk factors. Ann Neurol. 74:241-249. PMCID: PMC3836863 23536377 http://onlinelibrary.wiley.com/doi/10.1002/ana.23906/pdf

Faber JE (2012) Reprogrammed endothelial cells:  Cell therapy for coronary collateral growth?  Circ Res. 110:192-194, Invited editorial. http://circres.ahajournals.org/content/110/2/192.full.pdf+html

Lucitti JL, Mackey J, Morrison J, Haig J, Adams R, Faber JE (2012) Formation of the collateral circulation is regulated by vascular endothelial growth factor-A and A Disintegrin and Metalloprotease Family Members 10 and 17.  Circ Res. 111:1539-50.  http://circres.ahajournals.org/content/111/12/1539.long

Journal cover article and featured article.  Selected for Faculty of 1000 Biology-Exceptional. Editorial by Stephen Schwartz: http://f1000biology.com.

Wang S, Zhang H, Wiltshire T, Sealock R, Faber JE (2012) Genetic dissection of the Canq1 locus governing variation in extent of the collateral circulation.  PLoS ONE. 7:e31910. http://www.ncbi.nlm.nih.gov/pubmed/22412848

Faber JE, Zhang H, Prabhakar, RM Soares, Burnett MS, Epstein SE (2011) Aging causes collateral rarefaction and increased severity of ischemic injury in multiple tissues. Atheroscler Thromb Vasc Biol 31:1748-56.

Faber JE, Dai X, Lucitti J (2011) Genetic and environmental mechanisms controlling formation and maintenance of the native collateral circulation. In: Arteriogenesis – Molecular Regulation, Pathophysiology and Therapeutics I. E Deindl, W Schaper (eds), Shaker Verlag, Ch 1, pp 1-22.

Aitsebaomo J, Srivastava S, Zhang H, Jha S, Veleva AN, Pi X, Lockyer P, Winnick S, Faber JE*, Patterson C* (2010) Recombinant human interleukin-11 mobilizes CD34+/VEGFR2+ mononuclear cells and enhances collateral vessel growth after femoral artery ligation. Athero Thromb Vasc Biol 31:306-12. *Co-senior authors.

Wang S, Zhang H, Dai X, Sealock R, Faber JE (2010) Genetic architecture underlying variation in extent and remodeling of the collateral circulation. Circulation Res 107(4):558-68. Selected for Faculty of 1000 Biology-Exceptional. Editorial by Stephen Schwartz: http://f1000biology.com/article/id/3765959/evaluation. “This may well be the seminal paper in one of the most important mysteries in vascular biology: the mechanisms controlling collateral formation in the arterial tree…”

Chalothorn D, Faber JE (2010) Strain-dependent variation in native collateral function in mouse hindlimb. Physiol Genomics 42(3):469-79.

Zhang H, Prabhakar P, Sealock RW, Faber JE (2010) Wide genetic variation in the native pial collateral circulation is a major determinant of variation in severity of stroke. J Cerebral Blood Flow and Metabolism 30:923-934.

Chalothorn D, Faber JE (2010) Formation and maturation or the murine native cerebral collateral circulation. J Molec Cell Cardiol 49:251-259.

Dai X, Faber JE. (2010) eNOS deficiency causes collateral vessel rarefaction and impairs active-tion of a cell cycle gene network during arteriogenesis. Circ Res 106:1870-81. “Featured Article”, Journal Cover Article. Press release 5/25.

Chalothorn D, Zhang H, Smith JE, Edwards JE, Faber JE (2009) Chloride intracellular channel-4 is a determinant of native collateral formation in skeletal muscle and brain. Circulation Res 105:89-98. Journal cover article. Featured in editorial: Waltenberger J “Limits to growth of native collateral vessels. Just one mouse CLIC away from unlimited collateral perfusion?” p9-11

Clayton JA, Chalothorn D, Faber JE. (2008) Vascular endothelial growth factor-A specifies formation of native collat-erals and regulates collateral growth in ischemia. Circulation Res 103(9):1027-36. Featured in editorial: Chilian WM, Pung YF. “Vascular endothelial growth factor & the collateral circulation--the story continues.”

Chalothorn D, Clayton JA, Zhang H, Pomp D, Faber JE. (2007) Collateral density, remodeling and VEGF expression differ widely between mouse strains.  Physiol Genomics 30:179-91.  Featured as the Cover Article.