Fellner - Research

Function of Renal Vascular Smooth Muscle Cells: Receptors and Signal Transduction Pathways

Susan Fellner studies Ca2+ signaling in isolated fresh afferent arterioles of the renal vasculature. Recent work and planned experiments focus on the inter-relationships between pathways that augment cytosolic Ca2+ concentration following agonist stimulation of cell surface G-protein coupled receptors (e.g., angiotensin II, endothelin). Among the cell signal transduction mechanisms being investigated are the roles of the ADP ribosyl cyclase system, superoxide anions, the vascular smooth muscle ryanodine receptor and the potential relationship between TRPC cation channels and voltage-gated Ca2+ entry.