Lund - Publications

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Recent Publications:

 

Lund PK. Fixing the Breaks in Intestinal Stem Cells After Radiation: A Matter of DNA Damage and Death or DNA Repair and Regeneration. Gastroenterology. 2012 Sep 19. pii: S0016-5085(12)01377-7.

Vidal AC, Lund PK, Hoyo C, Galanko J, Burcal L, Holston R, Massa B, Omofoye O, Sandler RS, Keku TO.  Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosa.  BMC Cancer. 2012 Sep 5;12(1):389.

Ding S, Walton KL, Blue RE, Macnaughton K, Magness ST, Lund PK. Mucosal healing and fibrosis after acute or chronic inflammation in wild type FVB-N mice and C57BL6 procollagen α1(I)-promoter-GFP reporter mice. PLoS One. 2012;7(8):e42568. Epub 2012 Aug 3.

Van Landeghem L, Santoro MA, Krebs AE, Mah AT, Dehmer JJ, Gracz AD, Scull BP, McNaughton K, Magness ST, Lund PK. Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation. Am J Physiol Gastrointest Liver Physiol. 2012 May 15;302(10):G1111-32. Epub 2012 Feb 23.

Bortvedt SF, Lund PK. Insulin-like growth factor 1: common mediator of multiple enterotrophic hormones and growth factors. Curr Opin Gastroenterol. 2012 Mar;28(2):89-98. Review.

Hamilton KE, Simmons JG, Ding S, Van Landeghem L, Lund PK. Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells. Mol Cancer Res. 2011 Dec;9(12):1718-31. Epub 2011 Oct 12.

Ding S, Lund PK. Role of intestinal inflammation as an early event in obesity and insulin resistance. Curr Opin Clin Nutr Metab Care. 2011 Jul;14(4):328-33. Review.

Fiocchi C, Lund PK. Themes in fibrosis and gastrointestinal inflammation. Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G677-83. Epub 2011 Mar 17.

Leen JL, Izzo A, Upadhyay C, Rowland KJ, Dubé PE, Gu S, Heximer SP, Rhodes CJ, Storm DR, Lund PK, Brubaker PL. Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts. Endocrinology. 2011 Feb;152(2):436-46. Epub 2010 Dec 15.

Ding S, Chi MM, Scull BP, Rigby R, Schwerbrock NM, Magness S, Jobin C, Lund PK. High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PLoS One. 2010 Aug 16;5(8):e12191.

Hamilton KE, Lund PK, Galanko JA, Sandler RS, Keku TO. Suppressor of cytokine signaling 3 (SOCS3) is not an independent biomarker of colorectal adenoma risk. BMC Res Notes. 2010 May 25;3:144.

Newton VA, Ramocki NM, Scull BP, Simmons JG, McNaughton K, Lund PK. Suppressor of cytokine signaling-2 gene disruption promotes Apc(Min/+) tumorigenesis and activator protein-1 activation. Am J Pathol. 2010 May;176(5):2320-32. Epub 2010 Mar 26.

Speck KE, Garrison AP, Rigby RJ, von Allmen DC, Lund PK, Helmrath MA. Inflammation enhances resection-induced intestinal adaptive growth in IL-10 null mice. J Surg Res. 2011 Jun 1;168(1):62-9. Epub 2009 Oct 22.

Rigby RJ, Hunt MR, Scull BP, Helmrath MA, Lund PK. (2009) A new animal model of post-surgical inflammatory bowel disease and fibrosis: the effect of commensal microflora. Gut 58(8):1104-12

Garrison AP, Dekaney CM, VonAllmen DC, Lund PK, Henning SJ, Helmrath MA. (2009) Early but not late administration of glucagon-like peptide 2 following ileo-cecal resection augments putative intestinal stem cell expansion. Am J Physiol. 2009;296(3):G643-50.

Dekaney CM, von Allmen DC, Garrison AP, Rigby RJ, Lund PK, Henning SJ, Helmrath MA. (2008) Bacterial-Dependent Up-Regulation of Intestinal Bile Acid Binding Protein and Transport is FXR-Mediated Following Ileo-Cecal Resection. Surgery 144(2):174-81.

Zhang H, Morgan D, Cecil G, Burkholder A, Ramocki N, Scull B, Lund PK. (2008) Biochromoendoscopy: molecular imaging with capsule endoscopy for detection of polypoid lesions in the GI tract. Gastrointestinal Endoscopy 68(3):520-7. PMID:18499106.

Keku TO, Sandler RS, Simmons JG, Galanko J, Woosley JT, Proffitt M, Omofoye O, McDoom M, Lund PK. (2008) Local IGFBP-3 expression, apoptosis and risk of colorectal adenomas. Biomedical Central 8(1):143.

Robertson K, Lu Y, Qing Su, MD, Lund PK, Liu JL. (2008) A general and islet cell-enriched overexpression of IGF-I results in normal islet cell growth, hypoglycemia and significant resistance to experimental diabetes. Am J Physiol 294(5):E928-38.

Ramocki NM, Wilkins HR, Magness ST, Simmons JG, Scull BP, Lee GH, McNaughton KK, Lund PK. (2008) Insulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9. Endocrinology, 149(1): p. 261-7

Rigby RJ, Simmons JG, Greenhalgh CJ, Alexander WS and Lund PK. (2007) Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon. Oncogene, 26(33): p. 4833-41.

Dekaney CM, Fong JJ, Rigby RJ, Lund PK, Henning SJ, Helmrath MA. (2007) Expansion of intestinal stem cells associated with long-term adaptation following ileocecal resection in mice. Am J Physiol Gastrointest Liver Physiol, 293(5): p. G1013-22.