Philpot - Publications

Link to PubMed

Recent Publications:

Larsen RS, Smith IT, Miriyala J, Han JE, Corlew RJ, Smith SL, Philpot BDSynapse-Specific Control of Experience-Dependent Plasticity by Presynaptic NMDA Receptors. Neuron. 2014 Aug 20;83(4):879-93. doi: 10.1016/j.neuron.2014.07.039.

Judson MC, Sosa-Pagan JO, Delcid WA, Han JE, Philpot BD. Allelic specificity of Ube3a expression in the mouse brain during postnatal development.   J Comp Neurol. 2013 Nov 20.

King IF, Yandava CN, Mabb AM, Hsiao JS, Huang HS, Pearson BL, Calabrese JM, Starmer J, Parker JS, Magnuson T, Chamberlain SJ, Philpot BD, Zylka MJ. Topoisomerases facilitate transcription of long genes linked to autism. Nature. 2013 Sep 5;501(7465):58-62.

Kunz PA, Roberts AC, Philpot BD. Presynaptic NMDA receptor mechanisms for enhancing spontaneous neurotransmitter release. J Neurosci. 2013 May 1;33(18):7762-9.

Huang HS, Burns AJ, Nonneman RJ, Baker LK, Riddick NV, Nikolova VD, Riday TT, Yashiro K, Philpot BD, Moy SS. Behavioral deficits in an Angelman syndrome model: effects of genetic background and age. Behav Brain Res. 2013 Apr 15;243:79-90.

Riday TT, Dankoski EC, Krouse MC, Fish EW, Walsh PL, Han JE, Hodge CW, Wightman RM, Philpot BD, Malanga CJ. Pathway-specific dopaminergic deficits in a mouse model of Angelman syndrome. J Clin Invest. 2012 Dec 3;122(12):4544-54

Peixoto RT, Kunz PA, Kwon H, Mabb AM, Sabatini BL, Philpot BD, Ehlers MD. Transsynaptic signaling by activity-dependent cleavage of neuroligin-1. Neuron. 2012 Oct 18;76(2):396-409.

Kunz PA, Burette AC, Weinberg RJ, Philpot BD. Glycine receptors support excitatory neurotransmitter release in developing mouse visual cortex. J Physiol. 2012 Nov 15;590(Pt 22):5749-64.

Wallace ML, Burette AC, Weinberg RJ, Philpot BD. Maternal loss of Ube3a produces an excitatory/inhibitory imbalance through neuron type-specific synaptic defects. Neuron. 2012 Jun 7;74(5):793-800.

Mabb AM, Judson MC, Zylka MJ, Philpot BD. Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes. Trends Neurosci. 2011 Jun;34(6):293-303. Epub 2011 May 17. Review.

Huang HS, Allen JA, Mabb AM, King IF, Miriyala J, Taylor-Blake B, Sciaky N, Dutton JW Jr, Lee HM, Chen X, Jin J, Bridges AS, Zylka MJ, Roth BL, Philpot BD.Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons. Nature. 2011 Dec 21;481(7380):185-9. doi: 10.1038/nature10726.

Larsen RS, Corlew RJ, Henson MA, Roberts AC, Mishina M, Watanabe M, Lipton SA, Nakanishi N, Pérez-Otaño I, Weinberg RJ, Philpot BD. NR3A-containing NMDARs promote neurotransmitter release and spike timing-dependent plasticity. Nat Neurosci. 2011 Mar;14(3):338-44. Epub 2011 Feb 6.

Demyanenko GP, Riday TT, Tran TS, Dalal J, Darnell EP, Brennaman LH, Sakurai T, Grumet M, Philpot BD, Maness PF. NrCAM deletion causes topographic mistargeting of thalamocortical axons to the visual cortex and disrupts visual acuity. J Neurosci. 2011 Jan 26;31(4):1545-58.

Philpot BD, Zukin RS. Synapse-specific metaplasticity: to be silenced is not to silence 2B. Neuron. 2010 Jun 24;66(6):814-6.

Henson MA, Roberts AC, Pérez-Otaño I, Philpot BD. Influence of the NR3A subunit on NMDA receptor functions. Prog Neurobiol. 2010 May;91(1):23-37. Review.

Roberts AC, Díez-García J, Rodriguiz RM, López IP, Luján R, Martínez-Turrillas R, Picó E, Henson MA, Bernardo DR, Jarrett TM, Clendeninn DJ, López-Mascaraque L, Feng G, Lo DC, Wesseling JF, Wetsel WC, Philpot BD, Pérez-Otaño I. (2009) Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation. Neuron. 2009 Aug 13;63(3):342-56.

Yashiro K, Riday TT, Condon KH, Roberts AC, Bernardo DR, Prakash R, Weinberg RJ, Ehlers MD, Philpot BD. Ube3a is required for experience-dependent maturation of the neocortex. Nat Neurosci. 2009 May 10. [Epub ahead of print]

Henson MA, Roberts AC, Salimi K, Vadlamudi S, Hamer RM, Gilmore JH, Jarskog LF, Philpot BD. (2008) Developmental Regulation of the NMDA Receptor Subunits, NR3A and NR1, in Human Prefrontal Cortex.  Cereb Cortex. 2008 Feb 21. [Epub ahead of print]

Corlew R, Wang Y, Ghermazien H, Erisir A, Philpot BD. (2007) Developmental switch in the contribution of presynaptic and postsynaptic NMDA receptors to long-term depression. J Neurosci. 2007 Sep 12;27(37):9835-45.

Philpot BD, Cho KK, Bear MF. (2007) Obligatory Role of NR2A for Metaplasticity in Visual Cortex. Neuron 53:495-502.

Djukic B, Casper KB, Philpot BD, Chin LS, McCarthy KD. (2007) Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiation. Journal of Neuroscience 27:11354-65.

Yashiro K, Corlew R, Philpot BD. (2005) Visual deprivation modifies both presynaptic glutamate release and the composition of peri-/extrasynaptic NMDA receptors in adult visual cortex. Journal of Neuroscience 25:11684-11692.

Philpot BD, Espinosa JS, Bear MF. (2003) Evidence for altered NMDA receptor function as a basis for metaplasticity in visual cortex. J Neurosci 23:5583-5588.

Sawtell NB, Frenkel MY, Philpot BD, Nakazawa K, Tonegawa S, Bear MF. (2003) NMDA receptor-dependent ocular dominance plasticity in adult visual cortex. Neuron 38(6):977-985.

Philpot BD, Bear MF. (2002) Synaptic plasticity in an altered state. Neuron 33: 665-667.

Zeng H, Chattarji S, Barbarosie M, Rondi-Reig L, Philpot BD, Miyakawa T, Bear MF, Tonegawa S. (2001) Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working memory. Cell 107:617-629.

Snyder EM, Philpot BD, Huber KM, Dong X, Fallon JR, Bear MF. (2001) Internalization of ionotropic glutamate receptors in response to metabotropic glutamate receptor activation. Nat Neurosci 4:1079-1085.

Philpot BD, Sekhar AK, Shouval HZ, Bear MF. (2001) Visual experience and deprivation bidirectionally modify the composition and function of NMDA receptors in visual cortex. Neuron 29:157-169.

Philpot BD, Weisberg MP, Ramos MS, Sawtell NB, Tang Y-P, Tsien JZ, Bear MF. (2001) Effect of transgenic overexpression of NR2B on NMDA receptor function and synaptic plasticity in visual cortex. Neuropharmacology 41:762-770.