Mark Zylka, PhD


PhD, Harvard University, 1999

Molecules and Mechanisms for Pain and Autism; Angelman Syndrome Therapies


5109D Neuroscience Research Building
Campus Box 7545

Office (919) 966-2540 • Lab (919) 966-2541

Mark J. Zylka, PhD

Link to PubMed

Recent Publications:

Mabb AM, Kullmann PH, Twomey MA, Miriyala J, Philpot BD, Zylka MJ. Topoisomerase 1 inhibition reversibly impairs synaptic function. Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17290-5. doi: 10.1073/pnas.1413204111. Epub 2014 Nov 17. PMID: 25404338

Wright BD, Loo L, Street SE, Ma A, Taylor-Blake B, Stashko MA, Jin J, Janzen WP, Frye SV, Zylka MJ. The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron. 2014 May 21;82(4):836-47. doi: 10.1016/j.neuron.2014.04.006PMID: 24853942

IF King, CN Yandava, AM Mabb, JS Hsiao, H-S Huang, BL Pearson, JM Calabrese, J Starmer, JS Parker, T Magnuson, SJ Chamberlain, BD Philpot, MJ Zylka (2013) Topoisomerases facilitate transcription of long genes linked to autism. Nature, doi:10.1038/nature12504

McCoy ES, Taylor-Blake B, Street SE, Pribisko AL, Zheng J, Zylka MJ. Peptidergic CGRPα Primary Sensory Neurons Encode Heat and Itch and Tonically Suppress Sensitivity to Cold. Neuron. 2013 Apr 10;78(1):138-51. doi: 10.1016/j.neuron.2013.01.030. Epub 2013 Mar 21. PMID:23523592. [cover]

Hurt JK, Zylka MJ. PAPupuncture has localized and long-lasting antinociceptive effects in mouse models of acute and chronic pain. Mol Pain. 2012 Apr 23;8(1):28.

Huang HS, Allen JA, Mabb AM, King IF, Miriyala J, Taylor-Blake B, Sciaky N, Dutton JW Jr, Lee HM, Chen X, Jin J, Bridges AS, Zylka MJ, Roth BL, Philpot BD. Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons. Nature. 2011 Dec 21;481(7380):185-9. doi: 10.1038/nature10726.

Mabb AM, Judson MC, Zylka MJ, Philpot BD. Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes. Trends Neurosci. 2011 Jun;34(6):293-303. [cover]

Zylka MJ, Sowa NA. NT5E mutations and arterial calcifications. N Engl J Med. 2011 Apr 21;364(16):1579; author reply 1579-80.

Zylka MJ. Pain-relieving prospects for adenosine receptors and ectonucleotidases. Trends Mol Med. 2011 Apr;17(4):188-96. [cover]

Street SE, Zylka MJ. (2011). Emerging roles for ectonucleotidases in pain-sensing neurons. Neuropsychopharmacology 36:358.

Sowa NA, Street SE, Vihko P, Zylka MJ. (2010). Prostatic acid phosphatase reduces thermal sensitivity and chronic pain sensitization by depleting phosphatidylinositol 4,5-bisphosphate. J. Neurosci. 30:10282-10293.

Sowa NA, Voss MK, Zylka MJ. (2010) Recombinant ecto-5’-nucleotidase (CD73) has long lasting antinociceptive effects that are dependent on adenosine A1 receptor activation. Molecular Pain. 6:20.

Sowa NA, Taylor-Blake B, Zylka MJ. (2010) Ecto-5’-nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits. J. Neurosci. 30:2235-2244.

Taylor-Blake B, Zylka MJ. (2010) Prostatic acid phosphatase is expressed in peptidergic and nonpeptidergic nociceptive neurons of mice and rats. PLOS One 5(1):e8674. doi:10.1371/journal.pone.0008674.

Wang H, Zylka MJ. (2009) Mrgprd-expressing polymodal nociceptive neurons innervate most known classes of substantia gelatinosa neurons. J. Neurosci. 29:13202-13209.

Rau KK, McIlwrath SL, Wang H, Lawson JJ, Jankowski MP, Zylka MJ, Anderson DJ, Koerber HR. (2009) Mrgprd enhances excitability in specific populations of cutaneous murine polymodal nociceptors. J Neurosci. 29(26):8612-9.

Larsen RS, Zylka MJ, Scott JE. (2009) A high throughput assay to identify small molecule modulators of prostatic acid phosphatase. Current Chemical Genomics, 3:42-49.

Cavanaugh D, Lee H, Lo L, Shields S, Zylka MJ, Basbaum AI, Anderson DJ. (2009) Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc. Natl. Acad. Sci. USA, 106:9075-9080.

Sowa NA, Vadakkan K, Zylka MJ. (2009) Recombinant mouse PAP has pH-dependent ectonucleotidase activity and acts through A1-adenosine receptors to mediate antinociception. PLOS One, 4(1): e4248. doi:10.1371/journal.pone.0004248.

Zylka MJ, Sowa NA, Taylor-Blake B, Twomey MA, Herrala A, Voikar V, Vihko P. (2008) Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine. Neuron 60:111-22. [cover]

Dussor G, Zylka MJ, Anderson DJ, McCleskey EW. (2008) Cutaneous sensory neurons expressing the Mrgprd receptor sense extracellular ATP and are putative nociceptors. J. Neurophysiol. 99:1581-9.

Liu Y, Yang FC, Okuda T, Dong X, Zylka MJ, Chen CL, Anderson DJ, Kuner R, Ma Q. (2008) Mechanisms of compartmentalized expression of Mrg class G protein-coupled sensory receptors. J. Neurosci. 28: 125-32.

Campagnola L, Wang H, Zylka MJ. (2008) Fiber-coupled light-emitting diode for localized photostimulation of neurons expressing channelrhodopsin-2.  J Neurosci Methods. 169:27-33.

Liu Q, Vrontou S, Rice FL, Zylka MJ, Dong XD, Anderson DJ. (2007) Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch. Nature Neurosci. 10:946-8

Zylka MJ. (2005) Nonpeptidergic circuits feel your pain. Neuron 47:771-772.

Zylka M, Rice FL, Anderson, DJ. (2005) Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron 45:17-25.

Zylka MJ, Dong X, Southwell AL, Anderson DJ. (2003) Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Proc. Natl. Acad. Sci . USA 100:10043-10048.

Han S-K, Dong X, Hwang J-I, Zylka MJ, Anderson DJ, Simon MI. (2002) Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the G a q/11 pathway. Proc. Natl. Acad. Sci . USA 99:14740-14745.

Dong X, Han S-K, Zylka MJ, Simon MI, Anderson DJ. (2001) A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell 106:619-632.