October 2011 – Bhat Lab Receives Grant Support from the National Multiple Sclerosis (MS) Society for their research project entitled “Disorganization and Re-organization of Axonal Domains in Myelinated Axons.”
Dr. Manzoor Bhat and colleagues are studying mice that have been genetically modified to make them deficient in key proteins that contribute to the organization of the nodes and related regions in myelinated axons. This will allow investigations to understand the processes of how the axonal domains are organized and how these proteins affect the function of axons when myelin is damaged, and whether disorganized axonal domains can be re-organized in a timely manner to prevent axonal damage. This could lead to important clues about how to prevent nodal disorganization or treat the impacts of axon degeneration that leads to neurological deficits in MS.