Zylka lab finds that Mrgprd enhances excitability in nociceptive (pain-sensing) neurons

The Journal of Neuroscience publishes findings by the Zylka lab, in collaboration with labs at Caltech and the University of Pittsburgh, that the G protein-coupled receptor called Mrgprd enhances excitability in nociceptive (pain-sensing) neurons.

Zylka lab finds that Mrgprd enhances excitability in nociceptive (pain-sensing) neurons
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Journal of Neuroscience, July 2009
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Hong Wang, PhD

July 2009 - In a Journal of Neuroscience article, Mark Zylka’s lab, in collaboration with labs at Caltech and the University of Pittsburgh, publishes their findings that the G protein-coupled receptor called Mrgprd enhances excitability in nociceptive (pain-sensing) neurons. In addition, they found that Mrgprd molecularly marks a population of unmyelinated polymodal nociceptors.

Polymodal nociceptors were first physiologically identified and studied thirty years ago by UNC Professor Dr. Edward Perl [in Bessou and Perl (1969) J. Neurophysiol 32:1025-1043].

Dr. Hong Wang, a postdoctoral scholar in the Zylka lab, contributed to this study. Their paper is featured with a cover caption and can be found at: http://www.jneurosci.org/cgi/reprint/29/26/8612

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