January 2014 - Congratulations to Assistant Professor Stephanie Gupton, PhD, who will receive her first R01 funding from the National Institutes of Health - National Institute of General Medical Sciences for her project "TRIM9 coordinates membrane trafficking and cytoskeletal dynamics."
Using a combination of mouse genetics, primary cell culture, live cell imaging and neuroanatomical studies, the Gupton lab has found that TRIM9-deficient cortical neurons show misregulated exocytosis and defective actin and microtubule dynamics. Furthermore, cortical neurons devoid of TRIM9 have axon branching defects, are defective in netrin-based axon guidance, and have defective cortical axon fiber tracts in vivo. The goal of this study is to determine the molecular mechanisms by which TRIM9 regulates both cytoskeletal dynamics and vesicle trafficking to elicit axon branching, axon guidance, and neuroanatomical development.
This R01 will provide funding for five years.