IRB 13-0056

If you are interested in participating in this study,
contact our research coordinator using the contact information shown below.

Study Number:


Principal Investigator:

Michelle Hernandez


Vegetables such as broccoli, cauliflower, kale and cabbage are particularly rich in a plant chemical called sulforaphane (SFN) which boosts production of certain “defense” enzymes that increase the activity of gene expression of antioxidant genes in the nose.  In animals, the chemical protection from SFN helps prevent diseases associated with inflammation and cancer among others, and this is currently being studied in humans.  Young broccoli sprouts have a particularly high level of SFN compared to other foods. 


The purpose of this research study is to see if we can measure these changes in allergic, asthmatic  volunteers treated with broccoli sprout homogenates (BSH) or a placebo homogenate.  This will be done by obtaining a series of “nasal lavages” or rinses of the nose with salt water, as well as  superficial biopsies of the inside lining of the nose, and collecting sputum cells from your lungs.  Using these samples, we will measure the amount of proteins and the amount of inflammation in the  nose and and lungs and compare the results when you  are given a broccoli sprout homogenate “shake” (high in SFN) or a placebo “shake” (which is low in SFN) during 3 days during 2 different study sessions.


(919) 966.5638 or email or fill out a questionnaire



    • You must be between 18 and 50.
    • You should be a healthy nonsmoker and  have allergies and asthma.
    • You should not be pregnant or nursing.
    •  You should not have intolerance of or aversion to broccoli

    Time Commitment:

    Seven visits over up to 10 weeks with visit duration ranging from ½ -3 1/2 hours, and 2 sessions separated by at least 3 weeks


    Volunteers completing all study procedures will be compensated up to $575

    Review the Informed Consent Form:

    Informed Consent Form